[PDF] Top 20 Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.
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Nef from primary isolates of human immunodeficiency virus type 1 suppresses surface CD4 expression in human and mouse T cells.
... To test whether the expression of the consensus Nef protein also correlated with a decrease in surface CD4 expression, the transduced HuT-78 and AKR1-G1 cells were stained for human or m[r] ... See full document
9
Nef-Induced CD4 Endocytosis in Human Immunodeficiency Virus Type 1 Host Cells: Role of p56lck Kinase
... against mouse or rabbit immunoglobulin G ...cell surface CD4 was performed with phycoerythrin-cyanine 5-coupled anti- human CD4 (PE-Cy5 anti-human CD4; BD Pharmingen) or ... See full document
12
CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef.
... The human immunodeficiency virus type 1 (HIV-1) genes vpu, env, and nef have all been implicated in modulating the levels of cell surface CD4 on infected ... See full document
10
The cytoplasmic domain of CD4 is sufficient for its down-regulation from the cell surface by human immunodeficiency virus type 1 Nef.
... HPB-ALL and HuT-78 human CD4+ T cells and the CD4+ human monocyte/macrophage line U937 transduced with LNefSN or the control vector LN were analyzed for CD4 and p56lck expression.. Figur[r] ... See full document
10
Contribution of Vpu, Env, and Nef to CD4 Down-Modulation and Resistance of Human Immunodeficiency Virus Type 1-Infected T Cells to Superinfection
... on CD4 (Fig. 7C). The ability of Nef to inhibit superinfection even further, however, correlated signif- icantly with its ability to down-modulate CD4 ...that Nef may protect cells ... See full document
13
Vpr Is Required for Efficient Nef Expression from Unintegrated Human Immunodeficiency Virus Type 1 DNA
... activated CD4 ⫹ T cells in vivo ...and expression, although recent reports sug- gest that transcription from nonintegrated HIV DNA appears to be a normal early step in HIV ...or ... See full document
9
Human Immunodeficiency Virus Type 1 Nef-Mediated Downregulation of CD4 Correlates with Nef Enhancement of Viral Pathogenesis
... infected primary T cells, in which expression of Nef is controlled by the HIV-1 long terminal repeat and subjected to appropriate splic- ...FIG. 1. Downregulation of ... See full document
10
Strong Ability of Nef-Specific CD4+ Cytotoxic T Cells To Suppress Human Immunodeficiency Virus Type 1 (HIV-1) Replication in HIV-1-Infected CD4+ T Cells and Macrophages
... molecule expression of HIV-1 Nef-specific CD4 ⴙ T ...antigen-specific CD4 ⫹ T cells are classically thought to function as helper T cells in antiviral ... See full document
10
Human Immunodeficiency Virus Type 1 Vpr Protein Does Not Modulate Surface Expression of the CD4 Receptor
... reduce surface CD4, confirming a major role of this protein in the HIV-induced downmodulation of the viral re- ceptor 6, 14a, ...wild type, infection with a Vpr-defective virus efficiently ... See full document
6
Effects of CCR5 and CD4 Cell Surface Concentrations on Infections by Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1
... of primary T-cell-tropic HIV-1 are directly dependent on CD4 cell surface concentra- tions, whereas laboratory-adapted T-cell-tropic viruses can ef- ficiently infect cells ... See full document
10
Coreceptor Competition for Association with CD4 May Change the Susceptibility of Human Cells to Infection with T-Tropic and Macrophagetropic Isolates of Human Immunodeficiency Virus Type 1
... the cells that were found to be targets for human immunodeficiency virus (HIV) infection in vivo ...(i.e., T cells, macrophages, and dendritic cells) express both ... See full document
8
Human Immunodeficiency Virus Type 1 Nef-Induced CD4 Cell Surface Downregulation Is Inhibited by Ikarugamycin
... that Nef accomplishes CD4 down- modulation by acting as a connector between CD4 and host cell proteins that are part of the normal host cell endocytic machinery (17, 28, 38, ...of Nef-medi- ... See full document
5
Nef-Mediated Downregulation of CD4 Enhances Human Immunodeficiency Virus Type 1 Replication in Primary T Lymphocytes
... of CD4 downregulation and single-cycle infectivity enhancement by Nef to HIV-1 rep- lication efficiency, we quantified the abilities of a large collec- tion of nef point mutant viruses to ... See full document
9
Human Endothelial Cells Enhance Human Immunodeficiency Virus Type 1 Replication in CD4+ T Cells in a Nef-Dependent Manner In Vitro and In Vivo
... them from other APCs, which may underlie their seemingly unique signaling capacity to modulate HIV-1-infected T ...⫹ T cells stimulated by professional APCs express early activation ... See full document
13
Association of Nef with the Human Immunodeficiency Virus Type 1 Core
... protein Nef is essential for efficient replica- tion and pathogenesis of primate ...the nef open reading frame results in attenuation of simian immunodeficiency virus in rhesus macaques, and ... See full document
7
Expression and biochemical characterization of human immunodeficiency virus type 1 nef gene product.
... 10, which potentially affect the GTPase and GTP binding activities; iii different Nef aminoterminal sequence in the recombinant Nef protein, resulting from initiation at a putative start[r] ... See full document
8
Cyclosporine Increases Human Immunodeficiency Virus Type 1 Vector Transduction of Primary Mouse Cells
... BM cells is eliminated by treatment with CSA. (A) Freshly isolated mouse BM cells were infected with HIV-1 vector at 293T MOI of 2, 8, and 40 in the presence or absence of CSA (10 ...to ... See full document
6
Infection of SK-N-MC cells, a CD4-negative neuroblastoma cell line, with primary human immunodeficiency virus type 1 isolates.
... and human cells (7, ...all isolates in SK- N-MC cells, results with the SK-N-MC/CD4 cells, which were derived from the same parental stock, indicate that the differ- ences ... See full document
5
Differences in CD4 dependence for infectivity of laboratory-adapted and primary patient isolates of human immunodeficiency virus type 1.
... After that step, LA viruses efficiently infect cells even at very low cell surface CD4 concentrations, whereas infectivity of primary isolates is strongly dependent on the level of CD4 e[r] ... See full document
8
Nef-Mediated Resistance of Human Immunodeficiency Virus Type 1 to Antiviral Cytotoxic T Lymphocytes
... of nef on the immunogenicity and pathoge- nicity of HIV-1 infection suggests that this gene could be a target for enhancing cellular immunity in chronically infected individuals or the design of ... See full document
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