[PDF] Top 20 Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5.
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Processing and localization of Dengue virus type 2 polyprotein precursor NS3-NS4A-NS4B-NS5.
... The expression plasmid pLZ-345 gave rise to a 180-kDa protein in the transfected CV-1 cells which could react with either the anti-NS3 or anti-NS5 antibodies, whereas no cleavage of the [r] ... See full document
6
Processing of rabbit hemorrhagic disease virus polyprotein.
... exact localization of the proteolytic pro- cessing sites and also the specificity of 3C-like proteinase of RHDV, extracts of the strains harboring plasmids pRC56P, pRC37B, and pRC40B were separated by ... See full document
5
A central region in the hepatitis C virus NS4A protein allows formation of an active NS3-NS4A serine proteinase complex in vivo and in vitro.
... which NS4A enables the NS3 serine proteinase to cleave at the 4B/5A site is still ...that NS4A might act as a chaperone to mediate proper folding of the serine ...Although NS4A may participate ... See full document
8
Determinants in the Maturation of Rubella Virus P200 Replicase Polyprotein Precursor
... Rubella virus (RUBV), a positive-strand RNA virus, replicates its RNA within membrane-associated replication complexes (RCs) in the cytoplasm of infected ...NSP localization into foci appeared to ... See full document
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Complex formation between the NS3 serine-type proteinase of the hepatitis C virus and NS4A and its importance for polyprotein maturation.
... of NS3 via NS4A might have a dual function: to increase the proteinase concentration close to the substrate and to sequester the proteinase from rapid cel- lular ...of NS4A and that the proteinase ... See full document
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Crystal Structure of the NS3 Protease-Helicase from Dengue Virus
... fever virus (YFV), Japanese en- cephalitis virus, tick-borne encephalitis virus, West Nile virus (WNV), and dengue virus ...latter virus, neither a specific therapy nor a ... See full document
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Regulated Cleavages at the West Nile Virus NS4A-2K-NS4B Junctions Play a Major Role in Rearranging Cytoplasmic Membranes and Golgi Trafficking of the NS4A Protein
... of NS4A at the 4A-2K site prior to the postulated cleavage by cellular signalase downstream to release the mature NS4B protein from the 2K ...the NS4A-4B polyproteins lead to its accumulation, with ... See full document
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A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication
... of NS4B. Moreover, as shown here (Fig. 6C), similarly to wild-type 2K-NS4B, the K8A mutant protein coprecipitated with HA-NS4A when the two proteins were coexpressed, ruling out the ... See full document
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Nuclear localization of the NS3 protein of hepatitis C virus and factors affecting the localization.
... tein precursor of about 3,010 to 3,033 amino acid (aa) residues ...The polyprotein is cleaved by the host signal peptidase and two other virally encoded proteases to generate at least 10 viral proteins as ... See full document
8
NS5 of Dengue Virus Mediates STAT2 Binding and Degradation
... infection. Dengue virus (DENV) encodes several proteins (NS2a, NS4a, and NS4b) that have been shown individually to inhibit the IFN ...the virus, NS5, binds to STAT2 and is ... See full document
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Identification of Residues in the Dengue Virus Type 2 NS2B Cofactor That Are Critical for NS3 Protease Activation
... viral polyprotein at the NS2A/NS2B, NS2B/NS3, NS3/NS4A, and NS4B/NS5 junc- ...and NS4A proteins and within a C-terminal portion of NS3 itself were described in the ... See full document
9
Mutagenesis of the Dengue Virus Type 2 NS3 Protein within and outside Helicase Motifs: Effects on Enzyme Activity and Virus Replication
... of Dengue virus (types 1 to 4) belong to the family Flaviviridae, which consists of the genera Flavivirus, Pestivirus, and Hepacivirus ...The dengue virus genome is positive-sense RNA of 11 kb ... See full document
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Subcellular Localization, Stability, andtrans-Cleavage Competence of the Hepatitis C Virus NS3-NS4A Complex Expressed in Tetracycline-Regulated Cell Lines
... of NS3 and the NS3-NS4A ...of NS3 and the NS3-NS4A ...of NS3 pro- tein expression in UNS3 and UNS3-4A cells cultured for var- ious times in the absence or presence of ... See full document
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Interactions between the Dengue Virus Polymerase NS5 and Stem-Loop A
... initiating dengue virus RNA replication, interactions between NS5 and SLA have not been quantitatively analyzed, and thus, fundamental aspects of the NS5-SLA interaction, such as stoichiometry ... See full document
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A Genetic Interaction between Hepatitis C Virus NS4B and NS3 Is Important for RNA Replication
... additional NS3 mutations were also tested (P1115R, E1202G, D1431N, S1560G, and P1115R plus S1560G) (Table 2) and shown to rescue C1/H N 47 , C1/H Tm , and C1/H C 34 replication in a manner similar to that ... See full document
13
An amino-terminal domain of the hepatitis C virus NS3 protease is essential for interaction with NS4A.
... of processing kinetics with a precursor containing the nonstructural proteins from NS3 to NS5B has revealed that cleavages at the nonstructural sites are all relatively rapid: mature NS3, ... See full document
9
Antigenic variation of core, NS3, and NS5 proteins among genotypes of hepatitis C virus
... (e.g., dengue virus types 1 to 4), in which significant antigenic differences have been documented and which form the basis of their classifica- tion into ... See full document
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The NS4A Protein of Hepatitis C Virus Promotes RNA-Coupled ATP Hydrolysis by the NS3 Helicase
... in NS3 helicase assay buffer before being loaded onto a membrane sandwich, which consisted of a nitrocel- lulose membrane top layer ...ice-cold NS3 helicase assay ... See full document
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Chimeric Dengue Type 2 (Vaccine Strain PDK-53)/Dengue Type 1 Virus as a Potential Candidate Dengue Type 1 Virus Vaccine
... PDK-13 virus itself, was somewhat reduced compared to the neutralizing antibody ti- ters elicited by wild-type DEN-16007 virus and the three chi- meras expressing the structural genes of 16007 ... See full document
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Synthesis and processing of the precursor to the major core protein of adenovirus type 2.
... 107 cells/ml in Earle salt solution with 1/20 volume of 199 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest An isopycnic Metrizamide-detergent gradient system was devel[r] ... See full document
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