[PDF] Top 20 Quantifying the mapping precision of genome wide association studies using whole genome sequencing data
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Quantifying the mapping precision of genome wide association studies using whole genome sequencing data
... WGS data, however, 5e-8 seems inadequate to control the GWFPR at ...1KGP3-imputed data) (Additional file 1: Figure S2), consistent with the result from a previous study ...imputed data was not due to ... See full document
10
A goodness of fit association test for whole genome sequencing data
... in genome-wide association studies, genes discovered to date only account for a small proportion of overall genetic contributions to many complex ...traits. Association studies ... See full document
6
Incorporating ENCODE information into association analysis of whole genome sequencing data
... next-generation sequencing technology, a large number of whole genome sequences have been generated, enabling researchers to survey rare variants in the protein-coding and regulatory regions of the ... See full document
5
Genome wide association studies: a primer
... SNPs mapping to genes in a pathway show more evidence of association with a disorder than other SNPs in the GWAS, or SNPs mapping to other ... See full document
15
Genetic contributions to variation in general cognitive function: a meta-analysis of genome-wide association studies in the CHARGE consortium (N=53 949)
... the data presented here, it is not possible to identify a single SNP or gene within this region that is driving the association, as it is a gene-dense region that is known to exhibit a strong pattern of ... See full document
10
Genome-Wide Association Studies in Glioma.
... sequence-based association study in the Icelandic population led to the discovery of rs78378222 at ...The association with glioma was confirmed in an independent European study ...the association ... See full document
28
Analysis of homozygosity disequilibrium using whole genome sequencing data
... HD. Genome-wide homozygosity association analysis identified 5 and 3 ROHs associated with diastolic blood pressure and hypertension, ...Simulation studies showed that our homozygosity ... See full document
5
GENOME-WIDE ASSOCIATION STUDIES IN PHARMACOGENOMICS
... Genome wide association studies (GWAS) are genetic studies in which dense array of genetic markers that capture substantial proportion of common variations in the genome sequence ... See full document
9
A comparison of whole genome sequencing with exome sequencing for family based association studies
... DNA sequencing decreases, association studies based on whole genome sequencing are now becoming ...from whole genome sequencing compared to exome ... See full document
6
Multivariate methods and software for association mapping in dose‐response genome‐wide association studies
... genetic data, pharmacoge- nomics research has met little success in using this data to improve patient ...pharmacogenomics studies with human popu- lations often map a limited a priori set of ... See full document
15
Genome-Wide Association and Exome Sequencing Study of Language Disorder in an Isolated Population
... genetic association of SNPs with quantitative traits were performed under the additive model while controlling for sample structure estimated directly from data as a genetic relatedness ...family-based ... See full document
15
Extended T2 tests for longitudinal family data in whole genome sequencing studies
... Family data and rare variants are two key features of whole genome sequencing analysis for hunting the missing heritability of common human ...longitudinal whole genome ... See full document
6
An exploration of heterogeneity in genetic analysis of complex pedigrees: linkage and association using whole genome sequencing data in the MAP4 region
... sequence data for each pedigree, we performed 2-point linkage analysis across the MAP4 ...region. Association analyses, conducted for each single variant, included measured genotype (MG) analysis, which ... See full document
6
Comparative sequencing analysis reveals high genomic concordance between matched primary and metastatic colorectal cancer lesions
... blocks using the Qiagen DNeasy Blood & Tis- sue ...extracted using the Qiagen DNeasy Blood & Tis- sue Kit modified for deparaffinization and these sequencing results were used in place of the ... See full document
10
Association analysis of whole genome sequencing data accounting for longitudinal and family designs
... GAW18 whole genome sequence data were provided by the T2D-GENES Consortium which is supported by NIH grants U01 DK085524, U01 DK085584, U01 DK085501, U01 DK085526, and U01 ...phenotypic data ... See full document
7
Genome sequence of Coxiella burnetii strain Namibia
... BGM cells (Flow Laboratories, Rockville, MD, USA) were grown in Eagles minimal essential medium (MEM) supple- mented with Earls salts, 2 mM L-glutamax, 5% Fetal Calf Serum (FCS), 1% Non-Essential Amino acids (NEA) and ... See full document
9
Whole Genome Sequencing for Routine Pathogen Surveillance in Public Health: a Population Snapshot of Invasive Staphylococcus aureus in Europe
... of sequencing entire bacterial genomes in steady decline and the de- velopment of powerful bioinformatic tools gathering pace, whole- genome sequencing (WGS) will inevitably be widely ... See full document
15
Application of resequencing to rice genomics, functional genomics and evolutionary analysis
... constructed using a novel data-imputation ...cultivars using 1,917 SNPs to clarify the dynamics of the pedigree haplotypes (Yamamoto et ...on genome-wide SNP ana- lysis, these ... See full document
10
Selective Whole Genome Amplification Is a Robust Method That Enables Scalable Whole Genome Sequencing of Plasmodium vivax from Unprocessed Clinical Samples
... Multiple techniques have been developed to enrich Plasmodium genomic DNA (gDNA) from clinical samples, including leukocyte depletion (13–15), hybrid selection with RNA baits (16, 17), short-term ex vivo culture (18), ... See full document
15
Genome-wide association analysis of body conformation traits in Mexican Holstein cattle using a mix of sampled and imputed SNP genotypes.
... an association study utilizing 6,912 SNPs obtained using a low-density bovine SNPchip, and 39,611 imputed SNPs along the bovine ...genome. Association was performed for 16 traits related to ... See full document
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