[PDF] Top 20 Recent Developments in Atopic Dermatitis

... Despite its high prevalence, AD has historically been poorly understood, resulting in a paucity of approved treatment options for this burdensome disease. However, several important recent advances have been made ... See full document

... severe atopic dermatitis-like skin inflammation with ultrastructual analyses showing a marked increase in corneodesmosome cleavage and stratum corneum detachment, resulting in the loss of the stratum ... See full document

... The classical Th1/Th2 paradigm previously defining atopic dermatitis, psoriasis and lichen planus has recently been challenged with the discovery of T-helper 17 (Th17). Interleukin (IL) 23 is required for ... See full document

... exposure to certain parasitic infections and micro-organisms in early life, affects the development of the immune system. Specifically maturation of cell-mediated (i.e. Th1) immune responses and T-regulatory cell ... See full document

... The rapid rise in prevalence of atopic diseases has been ascribed to the so-called hygiene hypothesis. According to this theory, early infections or exposure to microbial-derived material, such as LPS, early in ... See full document

... The prevalence of AD has risen substantially in many countries in recent decades. AD not only leads to a low quality of life, but it also causes depression. AD affects the patients as well as their parents and ... See full document

... a recent study Nomura ...in atopic dermatitis [48], it can be assumed that the pres- ently observed increase in NT-3 production in MCs may also have functional effect on keratinocytes IL-8 secretion ... See full document

... Atopic dermatitis affects people of all ages but children are sometimes able to outgrow the condition. The physical effects of AD are unpleasant, but even more worrisome is the link to psychological and ... See full document

... as atopic dermatitis and psoriasis exhibit decreased barrier function, and recent studies suggest that the complex response of epidermal cells to barrier disruption may aggravate, maintain, or even ... See full document

... Abstract: Atopic dermatitis (AD) is a common chronic inflammatory skin disease affecting ~10–20% of the general population. AD is characterized by disturbances in epidermal barrier function and hyperactive ... See full document

... 17,18 Recent studies of high-risk atopic individuals showed that a raised TEWL may precede the clinical manifestation of AD in those at high risk of ... See full document

... Atopic dermatitis (AD) is a chronic, highly pruritic (itchy) inflammatory skin disease, and is one of the most common skin disorders in children [1]. The disor- der results in significant morbidity and ... See full document

... Although many clinical and laboratory studies have tried to understand AD and the progression of the atopic march, few data exist in order to determine the different phenotypes of AD. In a previous review, ... See full document

... A number of psychophysiological studies support the role of emotional factors in affecting the symptoms of atopic dermatitis through mechanisms under the influence of the autonomic nervo[r] ... See full document

... The intervention of SMWBG demonstrated improvement in the physical signs of AD in our cohort. This study supports the proposal that SMWBG provides a valuable adjunct therapy in the management of AD. There were no adverse ... See full document

... does atopic dermatitis affect the lives of infants, children and adults suffering from the disease, but also has major secondary effects on their ... See full document

... Staphylococcus aureus is a gram-positive pathogen that has been implicated in the pathogenesis of atopic dermatitis (AD). AD is one of the most frequent chronic inflammatory skin diseases and is found in ... See full document

... Comparison between methods & ISAC ’ s role in Asia A previous study of Korean patients with AD reported good correlation between ISAC and SPT. However, only a narrow range of allergens was included, the population ... See full document

... matitides, dermatitis venenata (poison ivy), diaper dermatitis, intertrigo, infectious eczematoid dermatitis, atopic dermatitis, atopic erythroderma, nummular eczema and circumscribed ne[r] ... See full document

... Autism Spectrum Disorders (ASD) are neurodevelopmental disturbances affecting social skills, whose incidence worldwide is dramatically increasing. Together with the rise of ASD prevalence, several immune conditions are ... See full document