[PDF] Top 20 A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... LAT transcript and indicate that the reactivation phe- notype resides at the 5 * ...induced reactivation, we sought to identify the genetic element(s) responsible for this ...poly(A) region ... See full document
11
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... the virus (TRL, terminal repeat long; IRL, internal repeat long; IRS, internal repeat short; TRS, terminal repeat short) that bound the unique long (UL) and unique short (US) ...LAT region (one in each long ... See full document
7
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... genomic region enhances the establishment of latency is not yet ...of virus production and immediate-early gene expression at the level of mRNA pro- duction ...the virus to replicate in ... See full document
16
Identification of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That both Inhibit Apoptosis and Enhance the Spontaneous Reactivation Phenotype
... The herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) gene is essential for the high spontaneous and induced reactivation ... See full document
6
Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism
... During latency, HSV-1 and HSV2-LAT-S1 did not re- activate ...lasting 1 to 2 days, similar in character to recurrences produced by HSV-2, HSV2-LAT-P1, and ...LAT region deletion mutants, ... See full document
9
A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... LAT transcript in wild-type virus and marker-rescued dLAT2903R is ...LAT region of dLAT2903 ...LAT transcript (indicated by “XXXXX”). This virus is missing key promoter elements, ... See full document
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The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... a transcript would fail to function in trans in an antisense capacity, regardless of whether it is derived from the viral or the host ...LAT region. Thus, the complicated GC-rich structure of this ... See full document
7
A 437-base-pair deletion at the beginning of the latency-associated transcript promoter significantly reduced adrenergically induced herpes simplex virus type 1 ocular reactivation in latently infected rabbits.
... epinephrine-induced reactivation could have been due to an inability to accumulate ...Syn17 1 , 17 D S/N, or 17 D S/N- Res, resolved through agarose gels, Northern blotted, and hy- bridized to a radioactive ... See full document
5
A Herpes Simplex Virus Type 1 Mutant Expressing a Baculovirus Inhibitor of Apoptosis Gene in Place of Latency-Associated Transcript Has a Wild-Type Reactivation Phenotype in the Mouse
... FIG. 1. Structure of the LAT region of dLAT-cpIAP and other viral ...LAT transcript prior to the start of the 2-kb LAT ...The region of LAT past the deletion is transcribed ... See full document
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The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... one type of posttranslational modification that can be present at specific histone amino acid residues, and acetylation of lysines 9 and 14 of histone H3 is typically enriched in transcriptionally permis- sive ... See full document
11
Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... the latency- reactivation cycle has been identified, suggesting that LAT regu- lates the latency-reactivation cycle by exerting its effect as an RNA molecule rather than by directing ... See full document
11
Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... of herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) expres- sion and processing in the absence of other cis and trans viral functions, ... See full document
10
Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... During latency of herpes simplex virus type 1 in sensory neurons, the transcription of viral genes is restricted to the latency-associated transcripts ...the ... See full document
11
A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... StyI-StyI region is required for LAT function when LAT is not in its normal ...StyI-StyI region may not be required in the context of the otherwise-complete LAT gene, but it is needed when only the first ... See full document
10
In vivo epinephrine reactivation of ocular herpes simplex virus type 1 in the rabbit is correlated to a 370-base-pair region located between the promoter and the 5' end of the 2.0 kilobase latency-associated transcript.
... 17Syn 1 , and 17 D Sty-Res from ex- plants of latently infected rabbit ...wild- type virus following in vivo epinephrine iontophoresis, it was possible that it would reactivate normally from TG ... See full document
5
The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... Herpes simplex virus type 1 establishes latent infections in sensory ...During latency only one locus, the latency-associated transcript (LAT), is abundantly ... See full document
9
Region of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient for Wild-Type Spontaneous Reactivation Promotes Cell Survival in Tissue Culture
... spontaneous reactivation by ...spontaneous reactivation, additional LAT de- letion mutants were constructed and tested in the rabbit ocular latency ...marker-rescued virus dLAT2903R, ...LAT ... See full document
11
ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency
... to 1 ml of HBSS containing 0.1% collagenase type I (Sigma Chemical ...a 1-ml serological ...4 1-ml aliquots were frozen at ⫺70°C thawed, sonicated, and tested immediately for the pres- ence of ... See full document
10
The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... Splicing of the 2.0-kb LAT is unusual during the limited splicing of HSV-1 infection. Of the more than 70 genes en- coded by HSV-1, only 6 generate transcripts that are spliced to any great extent (14, 25, ... See full document
10
Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... Once cytotoxic T cells are recruited to an infected area, they can eradicate target cells by inducing apoptosis by engaging the target cell’s Fas receptor with Fas ligand, found on the T cell’s surface (14, 33), and ... See full document
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