[PDF] Top 20 Regions of Human Immunodeficiency Virus Type 1nef Required for Function In Vivo
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Regions of Human Immunodeficiency Virus Type 1nef Required for Function In Vivo
... biologic function (14, 39, 51). Interestingly, deletion of several regions (deletions 1, 2, and 4) of this putative anchor domain had no effect on viral replication or ...a virus with a pathogenicity ... See full document
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G→A Hypermutation in Protease and Reverse Transcriptase Regions of Human Immunodeficiency Virus Type 1 Residing in Resting CD4+ T Cells In Vivo
... the virus into a new host cell (11, 16, 18, 35, ...that human immunodeficiency virus type 1 (HIV-1) Vif over- comes its effects ...similar function (33, 34), as GG and GA, ... See full document
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Nuclear Export of Human Immunodeficiency Virus Type 1 Vpr Is Not Required for Virion Packaging
... first function, Vpr enhances HIV-1 infectivity by stimulating the nuclear import of PICs (11, 18), an effect that is presumably mediated by the karyophilic properties of Vpr associated with these complexes (7, ... See full document
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Cooperation of Multiple CCR5 Coreceptors Is Required for Infections by Human Immunodeficiency Virus Type 1
... that virus dissociation or inactivation occurs at a competitively significant rate that can substantially influence HIV-1 titers in cell culture ...A virus hemagglutinin tri- mers required to form a ... See full document
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Dynamics and modulation of human immunodeficiency virus type 1 transcripts in vitro and in vivo.
... infection, which hampered the detection of a very short-lived phenomenon; otherwise, ACH-2 cells could be restrictive to Rev function (so that a high MS transcript level is necessary before US mRNA expression can ... See full document
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In Vivo Evidence for Instability of Episomal Human Immunodeficiency Virus Type 1 cDNA
... plasma viral RNA (1, 17, 34, 37, 42). In one study, emergence of the M184V mutation was compared in genomic viral RNA and viral DNA; however, there was no attempt to distinguish the emergence of the mutations in the ... See full document
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Human Immunodeficiency Virus Type 1 Protease Cleaves Procaspase 8 In Vivo
... Our data also provide insights into the potential reasons why not all T cells infected with HIV-1 die. In the case of virologic latency, absence of protease activity would be associated with absence of casp8p41 ... See full document
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Amino-Terminal Region of the Human Immunodeficiency Virus Type 1 Nucleocapsid Is Required for Human APOBEC3G Packaging
... in human APOBEC3G packaging into HIV-1 viri- ons, we compared the levels of virion-associated APOBEC3G in wild-type pNL4-3 and the viral genomic RNA packaging mu- tant pNC2/2 (25) in the presence of ... See full document
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Human Chromosome 2 Carries a Gene Required for Production of Infectious Human Immunodeficiency Virus Type 1
... infectious virus may not correlate linearly with the amount of Gag due to cooperative assembly effects (27), we went through some effort to demonstrate the following in select ...T1 function was ... See full document
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Myristoylation Is Required for Human Immunodeficiency Virus Type 1 Gag-Gag Multimerization in Mammalian Cells
... tion. MACANC at late times posttransfection was predomi- nantly found at the plasma membrane (Fig. 7A), while its nonmyristoylated counterpart was diffusely cytosolic (Fig. 7B). SrcCANC had a plasma membrane distribution ... See full document
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Membrane permeabilization by different regions of the human immunodeficiency virus type 1 transmembrane glycoprotein gp41.
... other regions of viral proteins involved in membrane fusion have been noted ...of immunodeficiency viruses maps at the amino terminus of gp41 (3, 5, 6, 25, ...proteins, required for HIV-1 viability ... See full document
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Functional Domains of Tat Required for Efficient Human Immunodeficiency Virus Type 1 Reverse Transcription
... is required at early stages of reverse transcription, al- though its exact role in this process has not been ...also function during viral assembly by either recruiting a cellular factor or modifying an ... See full document
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Viral RNA Is Required for the Association of APOBEC3G with Human Immunodeficiency Virus Type 1 Nucleoprotein Complexes
... stem regions of SL1 and SL3 in the ...NL4-3mS.3 virus stocks using a Vif-specific primer set. Helper virus (pC-Help) and NL4-3 virus stocks were analyzed in ...All virus preparations ... See full document
5
Conservation of an intact human immunodeficiency virus type 1 vif gene in vitro and in vivo.
... including two nonprogressors (gc1 and gc2), six slow progres- sors (i1, i2, i3, i4, ib, and id), and eight AIDS patients (gmk1 through gmk8). The vif region DNA was amplified by PCR and sequenced by direct sequencing, ... See full document
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Predicting the Impact of Blocking Human Immunodeficiency Virus Type 1 Nef In Vivo
... Human immunodeficiency virus type 1 (HIV-1) Nef is a multifunctional protein that confers an ability to evade killing by cytotoxic T lymphocytes (CTLs) as well as other advantages to the ... See full document
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Host-specific driving force in human immunodeficiency virus type 1 evolution in vivo.
... values for the three individuals (one donor and two recipients) were plotted as a function of corresponding nucleotide diver- gence, calculated under the Jukes-Cantor model of molecular evolution (29). By using ... See full document
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Effect of Ethanol on Monocytic Function in Human Immunodeficiency Virus Type 1 Infection
... cytic function after HIV-1 ...cytic function which could contribute to the progression and/or manifestations of HIV-1 ...the human macro- phage hybridoma cell line, clone 43, and primary monocytes, ... See full document
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Characterization of Simian Immunodeficiency Virus SIVSM/Human Immunodeficiency Virus Type 2 Vpx Function in Human Myeloid Cells
... of human monocyte-derived dendritic cells ...feline immunodeficiency virus, and even murine leukemia virus, leading us to suggest that Vpx counteracted an antiviral restriction present in ... See full document
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CD63 Is Not Required for Production of Infectious Human Immunodeficiency Virus Type 1 in Human Macrophages
... of human immunodeficiency virus type 1 (HIV-1) particles, a number of tetraspanins can be incorpo- rated into the viral membrane (6, 23, ...cellular function of CD63 remains unclear, a ... See full document
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Lys-34, Dispensable for Integrase Catalysis, Is Required for Preintegration Complex Function and Human Immunodeficiency Virus Type 1 Replication
... Integration is an essential step in the retroviral life cycle. It is catalyzed by the viral integrase (IN) acting upon the viral attachment (att) sites at the ends of linear viral cDNA within the context of a large ... See full document
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