[PDF] Top 20 Relationship between Human Immunodeficiency Virus Type 1 Gag Multimerization and Membrane Binding
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Relationship between Human Immunodeficiency Virus Type 1 Gag Multimerization and Membrane Binding
... the relationship between Gag multimerization and membrane binding by analyzing C-termi- nally truncated Gag proteins for their ability to form VLPs when singly expressed, ... See full document
9
Reversion of a Human Immunodeficiency Virus Type 1 Matrix Mutation Affecting Gag Membrane Binding, Endogenous Reverse Transcriptase Activity, and Virus Infectivity
... the relationship between protein structure and function and defines potential inter- and in- tramolecular ...and virus assembly (39) resulting from single amino acid substitutions in ...the ... See full document
10
Association of Human Immunodeficiency Virus Type 1 Gag with Membrane Does Not Require Highly Basic Sequences in the Nucleocapsid: Use of a Novel Gag Multimerization Assay
... Human immunodeficiency virus type 1 (HIV-1) particle production, a process driven by the Gag polyprotein precursor, occurs on the plasma membrane in most cell ... See full document
10
The I Domain Is Required for Efficient Plasma Membrane Binding of Human Immunodeficiency Virus Type 1 Pr55Gag
... expressing Gag-GFP fusion proteins. Gag protein expression constructs fused to a human codon-optimized form of green fluores- cence protein (GFP) were used in this ...The Gag coding sequences ... See full document
10
The Nucleocapsid Region of Human Immunodeficiency Virus Type 1 Gag Assists in the Coordination of Assembly and Gag Processing: Role for RNA-Gag Binding in the Early Stages of Assembly
... NC, Gag relies on a much smaller RNA-binding site in MA for assembly (7, ...RNA- binding properties of NC (15 amino acids spanning 50 posi- tions) ...for Gag (45). Thus, with respect to ... See full document
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Quantitative Fluorescence Resonance Energy Transfer Microscopy Analysis of the Human Immunodeficiency Virus Type 1 Gag-Gag Interaction: Relative Contributions of the CA and NC Domains and Membrane Binding
... the multimerization phenotypes of Gag CA- CTD and NC mutants, we compared FRET levels in homo- typic expression ...measured between constructs which both contain identical mutations) with those in ... See full document
15
Analysis of Human Immunodeficiency Virus Type 1 Gag Dimerization-Induced Assembly
... precursor Gag (PrGag) pro- teins of retroviruses such as human immunodeficiency virus (HIV), Rous sarcoma virus (RSV), and murine leukemia vi- ruses are sufficient for the production of ... See full document
9
Influence of gag on Human Immunodeficiency Virus Type 1 Species-Specific Tropism
... in human cells because target cell CypA blocks HIV-1 ...Lv1 virus complex, as revealed by a decrease in restriction on CSA addition in simian ...a virus is insensitive to Lv1, then the effect ... See full document
7
Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids.
... Here we demonstrate that the N-terminal region of HIV-1 Gag contains a bipartite membrane-targeting signal, consisting of the myristylated N-terminal 14 amino acids arld an additional re[r] ... See full document
14
Binding of the human immunodeficiency virus type 1 Gag polyprotein to cyclophilin A is mediated by the central region of capsid and requires Gag dimerization.
... that Gag interacts with CyPA before associating with the plasma mem- brane, previous studies have shown that mutations or drugs which disrupt the Gag-CyPA interaction have no gross effect on particle ... See full document
12
Electrostatic Interactions Drive Membrane Association of the Human Immunodeficiency Virus Type 1 Gag MA Domain
... plasma membrane. Membrane association is directed by MA, the N-terminal domain of the Gag structural ...For human immunodeficiency virus type 1 (HIV-1), this ... See full document
12
A Bipartite Membrane-Binding Signal in the Human Immunodeficiency Virus Type 1 Matrix Protein Is Required for the Proteolytic Processing of Gag Precursors in a Cell Type-Dependent Manner
... taining 1% Triton X-100, and the cell lysates were clarified by centrifugation at 14,000 rpm for 20 ...containing 1% Triton ...containing 1% Triton ... See full document
8
Particle Size Determinants in the Human Immunodeficiency Virus Type 1 Gag Protein
... retroviral Gag protein plays the central role in the assembly process and can form membrane-enclosed, virus-like particles in the absence of any other viral ...the human ... See full document
11
Rapid Localization of Gag/GagPol Complexes to Detergent-Resistant Membrane during the Assembly of Human Immunodeficiency Virus Type 1
... by human immunode- ficiency virus type 1 (HIV-1) Gag (14, 16, 21, 49), and putative regions of interactions between Gag molecules have been iden- tified as ... See full document
12
Opposing Effects of Human Immunodeficiency Virus Type 1 Matrix Mutations Support a Myristyl Switch Model of Gag Membrane Targeting
... a membrane-spanning subunit (TM) ...plasma membrane via the secretory ...the membrane-spanning region can completely sup- press the Env incorporation defect of MA mutants (17, ... See full document
9
Human Immunodeficiency Virus Type 1 Gag Polyprotein Multimerization Requires the Nucleocapsid Domain and RNA and Is Promoted by the Capsid-Dimer Interface and the Basic Region of Matrix Protein
... among Gag polypro- tein monomers. Budding deficient HIV-1 gag mutants can be efficiently rescued in trans by wild-type gag as long as they carry NC sequences (3, ...the Gag ... See full document
14
Human Immunodeficiency Virus Type 1 Gag Polyprotein Modulates Its Own Translation
... mutant Gag proteins, in addition to wild-type Gag, de- signed such that their RNA-binding activity would be dis- ...of Gag contains two CCHC zinc fingers, as well as basic residues at ... See full document
9
Role of the Gag Matrix Domain in Targeting Human Immunodeficiency Virus Type 1 Assembly
... extracellular virus production due to retargeting of virus as- sembly to intracellular vesicles ...vitro membrane bind- ing assays (70) it was proposed that the highly basic domain, along with basic ... See full document
12
Cytosolic Gag p24 as an Index of Productive Entry of Human Immunodeficiency Virus Type 1
... ligand binding still function as HIV coreceptors ...(iii) binding and cross-linking by multivalent virus parti- cles may induce endocytic behavior of cell surface receptors different from that ... See full document
5
Specific binding of human immunodeficiency virus type 1 (HIV-1) Gag-derived proteins to a 5' HIV-1 genomic RNA sequence.
... retroviral Gag protein is synthesized as a polyprotein which is cleaved by a virally encoded protease shortly after, or concomitant with, viral budding (12, ...RNA binding and packaging, but deletion of ... See full document
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