[PDF] Top 20 Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein.
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Replication and neutralization of human immunodeficiency virus type 1 lacking the V1 and V2 variable loops of the gp120 envelope glycoprotein.
... revertant virus, the KpnI-BamHI env fragments (nucleotides 5928 to 8054) were amplified by PCR from genomic DNA of infected Jurkat ...the V1-V2 loop ...pro- virus (16) and into plasmid ... See full document
5
Infectivity and Neutralization of Simian Immunodeficiency Virus with FLAG Epitope Insertion in gp120 Variable Loops
... within variable loop 1 (V1), 2 (V2), or 4 (V4) of the gp120 envelope glycoprotein of simian immunodeficiency virus strain 239 (SIV239) to evaluate the extent ... See full document
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Emergence of gp120 V3 Variants Confers Neutralization Resistance in an R5 Simian-Human Immunodeficiency Virus-Infected Macaque Elite Neutralizer That Targets the N332 Glycan of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein
... 14. McLellan JS, Pancera M, Carrico C, Gorman J, Julien JP, Khayat R, Louder R, Pejchal R, Sastry M, Dai K, O’Dell S, Patel N, Shahzad-ul Hussan S, Yang Y, Zhang B, Zhou T, Zhu J, Boyington JC, Chuang GY, Diwanji D, ... See full document
7
Probing the structure of the V2 domain of human immunodeficiency virus type 1 surface glycoprotein gp120 with a panel of eight monoclonal antibodies: human immune response to the V1 and V2 domains.
... Discontinuous, conserved neutralization epitopes overlapping the CD4 binding region of the human immunodeficiency virus type 1 gpl20 envelope glyco- HIV-1 gpl2O Vl AND V2 DOMAINS.[r] ... See full document
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Two N-Linked Glycosylation Sites in the V2 and C2 Regions of Human Immunodeficiency Virus Type 1 CRF01_AE Envelope Glycoprotein gp120 Regulate Viral Neutralization Susceptibility to the Human Monoclonal Antibody Specific for the CD4 Binding Domain
... Env gp120 in 65CC1 and ...the V1 and V2 regions of 65CC4 were 2 and 13 amino acids shorter than those of 65CC1, respectively ...Env gp120, the locations of a few PNLG sites dif- fered in 65CC1 ... See full document
10
Optimization of Human Immunodeficiency Virus Type 1 Envelope Glycoproteins with V1/V2 Deleted, Using Virus Evolution
... The human immunodeficiency virus type 1 envelope glycoprotein (Env) complex is the principal focus of neutralizing antibody-based ...three gp120 molecules and three ... See full document
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Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding.
... mutant gp120 recognition by antibodies. COS-1 cells were transfected with 10 m g of pSVIIIenv DNA expressing wild-type or mutant HXBc2 envelope glycoproteins and a Tat-expressing plasmid, ... See full document
11
Importance of the V1/V2 Loop Region of Simian-Human Immunodeficiency Virus Envelope Glycoprotein gp120 in Determining the Strain Specificity of the Neutralizing Antibody Response
... particular envelope immunogens tested have characteristically displayed low potency and/or high strain-spe- cific neutralizing ...an envelope-based immunogen that will elicit antibodies focused on conserved ... See full document
13
Antibody cross-competition analysis of the human immunodeficiency virus type 1 gp120 exterior envelope glycoprotein.
... surface glycoprotein gp120 of human immunodeficiency virus type 1 (HIV-1) is the major target for virus-neutralizing antibodies ...mature gp120 ... See full document
12
CD4-Induced Conformational Changes in the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein: Consequences for Virus Entry and Neutralization
... HIV-1 gp120 glycoprotein induced by interac- tion with the CD4 receptor (54, 55, ...of envelope glyco- proteins from both TCLA and primary HIV-1 isolates and that the 17b antibody binds ... See full document
10
Introduction of Exogenous Epitopes in the Variable Regions of the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein: Effect on Viral Infectivity and the Neutralization Phenotype
... viral neutralization potential have been examined (14, 19, 22, ...distinct neutralization phenotypes in response to anti-HIV NAbs; they found that all three pseudotyped viruses were equivalently neutralized ... See full document
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Genetic diversity of the highly variable V1 region interferes with Human Immunodeficiency Virus type 1 envelope functionality
... Figure 1 Strategy and sequences used in the present ...unstructured loops V1 and V2 are indicated in red and blue, respectively, whereas the small loop connecting β -sheets B and C is drawn in ... See full document
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Sequence diversity of V1 and V2 domains of gp120 from human immunodeficiency virus type 1: lack of correlation with viral phenotype.
... in human immunodefi- ciency virus type 1 (HIV-1) has been shown for independent viral isolates (1, 42), for sequential isolates from the same patient (15, 18, 41), and within a ... See full document
8
Cooperation of the V1/V2 and V3 Domains of Human Immunodeficiency Virus Type 1 gp120 for Interaction with the CXCR4 Receptor
... Human immunodeficiency virus type 1 (HIV-1) entry is triggered by the interaction of the gp120 envelope glycoprotein with a cellular chemokine receptor, ... See full document
8
Loss of a Single N-Linked Glycan Allows CD4-Independent Human Immunodeficiency Virus Type 1 Infection by Altering the Position of the gp120 V1/V2 Variable Loops
... the envelope glycoproteins responsible for the conversion of a primary, CCR5-using HIV-1 isolate from a virus dependent on the presence of CD4 on the target cells to a virus that no longer ... See full document
9
Functional role of the V1/V2 region of human immunodeficiency virus type 1 envelope glycoprotein gp120 in infection of primary macrophages and soluble CD4 neutralization.
... Structural studies of recombinant and mutant envelope glycoproteins suggest that the function of the V1/V2 region is to interact with the V3 domain and confer on the envelope gpl20 of HI[r] ... See full document
7
Impact of amino acid substitutions in the V2 and C2 regions of human immunodeficiency virus type 1 CRF01 AE envelope glycoprotein gp120 on viral neutralization susceptibility to broadly neutralizing antibodies specific for the CD4 binding site
... mutants lacking N186 or N197, except 45CC1- and 105PL2-derived mutants, did not reduce the VRC01 susceptibility of AE-Env clones (Table 9), suggesting that the amino acid residue at 185 had no major role in the ... See full document
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Association of Structural Changes in the V2 and V3 Loops of the gp120 Envelope Glycoprotein with Acquisition of Neutralization Resistance in a Simian-Human Immunodeficiency Virus Passaged In Vivo
... the V1/V2 stem-loop struc- ture, which has been implicated in modulation of neutraliza- tion sensitivity in other contexts (3, 32, ...the V1 loop, involves the acquisition of an N-linked ... See full document
8
Cooperative effects of the human immunodeficiency virus type 1 envelope variable loops V1 and V3 in mediating infectivity for T cells.
... the V1 loop in virus ...the V1 region of Env can affect syncy- tium formation (44) as well as viral tropism (3, 44, ...the V1 loop seven residues C terminal to the V1 change described ... See full document
7
Human Immunodeficiency Virus Type 1 V1-V2 Envelope Loop Sequences Expand and Add Glycosylation Sites over the Course of Infection, and These Modifications Affect Antibody Neutralization Sensitivity
... infection, human immunodeficiency virus type 1 (HIV-1) continuously adapts to evade the evolving host neutralizing antibody ...the envelope variable loop sequences, ... See full document
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