[PDF] Top 20 Replication of ICP0-Null Mutant Herpes Simplex Virus Type 1 Is Restricted by both PML and Sp100
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Replication of ICP0-Null Mutant Herpes Simplex Virus Type 1 Is Restricted by both PML and Sp100
... stimulate ICP0-null mutant HSV-1 plaque formation in either human fibroblasts or HepaRG cells, although it did increase plaque numbers in Vero cells ...increase ICP0-null ... See full document
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The Two Functions of Herpes Simplex Virus 1 ICP0, Inhibition of Silencing by the CoREST/REST/HDAC Complex and Degradation of PML, Are Executed in Tandem
... R8508 mutant virus per ...to ICP0 and monoclonal an- tibody to ...cells, PML was entirely contained in punctate nuclear struc- tures known as ND10 ...HSV-1(vCPc0), PML was no ... See full document
7
Recruitment of Polymerase to Herpes Simplex Virus Type 1 Replication Foci in Cells Expressing Mutant Primase (UL52) Proteins
... the herpes simplex virus (HSV) type 1 replication apparatus leading to replication compartments likely involves the initial assembly of five viral replication ... See full document
11
Attenuated, Replication-Competent Herpes Simplex Virus Type 1 Mutant G207: Safety Evaluation in Mice
... Mutations in a number of nonessential viral genes, including the ␥34.5 (61, 66, 71, 86), ICP6 (27, 28), TK (12), uracil DNA glycosylase (UL2) (62), and ICP0 (42) genes, affect the ability of HSV to establish ... See full document
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Mechanisms of Host IFI16, PML, and Daxx Protein Restriction of Herpes Simplex Virus 1 Replication
... that PML might act antivirally or provirally depending on the MOI ...which PML had been depleted or not with 7134 virus at an MOI of ...of PML in HFF cells by use of siRNAs led to ... See full document
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Expression of Human Cytomegalovirus IE1 Leads to Accumulation of Mono-SUMOylated PML That Is Protected from Degradation by Herpes Simplex Virus 1 ICP0
... and herpes simplex viruses (HSV) have evolved the ability to disperse nuclear domain 10 (ND10, aka PML ...produces ICP0, which degrades the ND10-forming protein ...deSUMOylates PML to ... See full document
12
Two Overlapping Regions within the N-Terminal Half of the Herpes Simplex Virus 1 E3 Ubiquitin Ligase ICP0 Facilitate the Degradation and Dissociation of PML and Dissociation of Sp100 from ND10
... the ICP0 structure-function analyses highlight- ing the importance of other motifs/regions in ICP0 ...that ICP0 can interact with a particular iso- form of PML (i.e., PML I) in ... See full document
10
Impaired STING Pathway in Human Osteosarcoma U2OS Cells Contributes to the Growth of ICP0-Null Mutant Herpes Simplex Virus
... the virus encodes multiple ...the virus, infected cell protein 0 (ICP0), has two major functions: it is a promiscuous transactivator of genes introduced into the cells by infection or transfection, ... See full document
14
Herpes Simplex Virus Type 1 ICP0 Phosphorylation Mutants Impair the E3 Ubiquitin Ligase Activity of ICP0 in a Cell Type-Dependent Manner
... Herpes simplex virus type 1 (HSV-1) infected cell protein 0 (ICP0) is a 110-kDa nuclear phosphoprotein that is required for both the efficient initiation of lytic ... See full document
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Herpes Simplex Virus 1 Ubiquitin Ligase ICP0 Interacts with PML Isoform I and Induces Its SUMO-Independent Degradation
... Herpes simplex virus 1 (HSV-1) immediate-early protein ICP0 localizes to cellular structures known as promyelocytic leukemia protein (PML) nuclear bodies or ND10 and ... See full document
14
ND10 Protein PML Is Recruited to Herpes Simplex Virus Type 1 Prereplicative Sites and Replication Compartments in the Presence of Viral DNA Polymerase
... a virus lacking the polymerase, but they do not contain ...polymerase null mutant to recruit PML into stage III ...of PML to replication ...UL42 null virus, ... See full document
8
Gamma Interferon (IFN-γ) Receptor Null-Mutant Mice Are More Susceptible to Herpes Simplex Virus Type 1 Infection than IFN-γ Ligand Null-Mutant Mice
... HSV-1 replication and latency (32, 36). After ocular inocula- tion, HSV-1 spreads by retrograde axonal transport to sensory ganglionic and central nervous system neurons, where com- pensatory ... See full document
5
ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency
... wild-type herpes simplex virus type 1 (HSV-1), ICP0-null mutant viruses reactivate inefficiently from explanted, latently infected mouse trigeminal ... See full document
10
Transient Expression of Herpes Simplex Virus Type 1 ICP22 Represses Viral Promoter Activity and Complements the Replication of an ICP22 Null Virus
... ICP22 null vi- ruses to infection with WT HSV-1 have revealed several inter- esting mutant ...for replication of HSV-1 in cell culture; however; the absence of ICP22 reduces the ... See full document
11
Packaging of Genomic and Amplicon DNA by the Herpes Simplex Virus Type 1 UL25-Null Mutant KUL25NS
... The herpes simplex virus type 1 (HSV-1) mutant KUL25NS, containing a null mutation within the UL25 gene, was isolated and characterized by McNab and coworkers ... See full document
11
The herpes simplex virus type 1 regulatory protein ICP0 enhances virus replication during acute infection and reactivation from latency.
... To compare the transactivating activities of ICPO mutant peptides with the reactivation frequencies of ICPO nonsense mutant viruses, ganglia latently infected with mutant and wild-type v[r] ... See full document
12
Phosphorylation Site Mutations Affect Herpes Simplex Virus Type 1 ICP0 Function
... The herpes simplex virus type 1 (HSV-1) immediate-early (IE) regulatory protein infected-cell protein 0 (ICP0) is a strong and global transactivator of both viral ... See full document
12
Role of Cyclin D3 in the Biology of Herpes Simplex Virus 1 ICP0
... the mutant virus to replicate in quiescent cells or to cause mortality in mice infected by a peripheral ...of ICP0. We report the following results. (i) Wild-type ICP0 activates cyclin ... See full document
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Recruitment of Herpes Simplex Virus Type 1 Immediate-Early Protein ICP0 to the Virus Particle
... of ICP0 from the nu- cleus to the cytoplasm. The ICP0 translocation pathway would suggest that VP22 does not have an involvement in the com- partmentalization of ...Furthermore, ICP0 translocates to ... See full document
15
Nuclear export of VP19C is not essential for replication of herpes simplex virus type 1
... lytic replication, a VP19C NES-mutated recombinant virus was ...and restricted fragment length polymorphisms (RFLP) analysis. The mutant pVP19C NESm/17-37BAC showed BamHI digestion patterns ... See full document
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