[PDF] Top 20 Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720.
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Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720.
... Indeed, the quinoxaline derivative has broad-spectrum activity against various mutant HIV-1 strains that are resistant to other HIV-1-specific RT inhibitors; i.e., quinoxaline S-2720 is [r] ... See full document
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Characteristics of the Pro225His mutation in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase that appears under selective pressure of dose-escalating quinoxaline treatment of HIV-1.
... their 1-position substituents approach the mouth of the NNRTI-binding pocket ...smallest 1-position substituent, and thus it might be expected that the activities of the other compounds ... See full document
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Genotypic, Phenotypic, and Modeling Studies of a Deletion in the β3-β4 Region of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Gene That Is Associated with Resistance to Nucleoside Reverse Transcriptase Inhibitors
... dine resistance mutation M184V or the Q151M ...of resistance con- ferred by the T215Y mutation (15) but not by the Q151M mutation ...3TC resistance without compromising AZT ...3TC resistance ... See full document
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Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions
... processing of Gag-Pol and/or Gag (1, 16, 21), we considered the possibility that the point mutations affected the folding of Gag-Pol. However, the amount of PR and IN is normal or near normal in our mutants, ... See full document
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Influence of Reverse Transcriptase Variants, Drugs, and Vpr on Human Immunodeficiency Virus Type 1 Mutant Frequencies
... drug resistance is a major complication of human immunodeficiency virus type 1 (HIV-1) ...HIV-1 reverse transcriptase (RT) is a major target of ... See full document
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Cross-Linking of the Fingers Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Template-Primer
... with resistance to nucleoside analog RT inhibitors acted by altering the position of the nucleic acid substrate relative to ...analog resistance in direct contact with the incoming ...drug resistance ... See full document
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Comparison of Sequencing by Hybridization and Cycle Sequencing for Genotyping of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... zidovudine resistance mutation more pivotal and common than that at RT codon 67), at which 10% of isolates had an ambiguous amino acid sequence as determined by cycle ... See full document
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Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... drug resistance muta- tions alter the mutation frequency of HIV-1 subtype B and CRF01_A/E, we have conducted structural analyses by inte- grating HIV-1 RT structure-function information into the fol- ... See full document
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Viral resistance to human immunodeficiency virus type 1-specific pyridinone reverse transcriptase inhibitors.
... 4887 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Human immunodeficiency virus type 1 HIV-1-specific pyridinone reverse transcriptase RT inhibitors prevent HIV-1 rep[r] ... See full document
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A 6 basepair insert in the reverse transcriptase gene of human immunodeficiency virus type 1 confers resistance to multiple nucleoside inhibitors
... 15 s, 63 8 for 20 s, and 72 8 C for 2 min, followed by a 10-min hold at 72 8 ...diluted 1:4 with water, and 10 m l of each were placed into sequencing reactions with dRhodamine dye–labeled ... See full document
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Worldwide Evaluation of DNA Sequencing Approaches for Identification of Drug Resistance Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... mutant human immunodefi- ciency virus type 1 (HIV-1) reverse transcriptase was analyzed by automated DNA sequencing in 23 labora- tories ...Drug resistance ... See full document
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Frequency of Mutations Conferring Resistance to Nucleoside Reverse Transcriptase Inhibitors in Human Immunodeficiency Virus Type 1 Infected Patients in Korea
... NRTI resistance muta- tions (41L, 67N/E, 69N/S/A, 70R, 74V, 118I, 184V/I, 210W, 215S/F/Y, and ...of resistance mutations after the initiation of monotherapy with ZDV, 3TC, or ddI was 7, 3, or 14 ... See full document
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The Impact of Multidideoxynucleoside Resistance-Conferring Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Polymerase Fidelity and Error Specificity
... Spectra of mutations by wild-type and multidrug-resistant HIV-1 RTs. In order to determine the specificity of mutations generated during the gap fill-in DNA synthesis reaction, M13 templates from 117 ... See full document
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Insertions in the Reverse Transcriptase Increase both Drug Resistance and Viral Fitness in a Human Immunodeficiency Virus Type 1 Isolate Harboring the Multi-Nucleoside Reverse Transcriptase Inhibitor Resistance 69 Insertion Complex Mutation
... wild type ⬎ T69S ⬎ SS ⱖ T69SSS ⬎ 2S0S ⬎ 2S4S (Table 1; ...the virus with the RT from the original clinical HIV-1 isolate (SS) was slightly more fit than the wild- type virus with ... See full document
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In Vitro Characterization of a Simian Immunodeficiency Virus-Human Immunodeficiency Virus (HIV) Chimera Expressing HIV Type 1 Reverse Transcriptase To Study Antiviral Resistance in Pigtail Macaques
... by reverse transcription and real-time PCR am- plification, with an amplicon in HIV-1 ...and 1 l of each sample by a guanidinium-isothiocyanate extraction method, as described previously ... See full document
9
High-Level Resistance to 3′-Azido-3′-Deoxythimidine due to a Deletion in the Reverse Transcriptase Gene of Human Immunodeficiency Virus Type 1
... ble 1). Mutations associated with resistance to AZT (M41L, K70R, L215F, and K219Q), 3TC (M184V), and NNRTIs (K103N, A98G, L74I, Y188C, and P236M) were detected ...V179D/E) resistance (15, 25, ... See full document
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Effects of Amino Acid Substitutions at Position 115 on the Fidelity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... during reverse transcription in vivo, RT in the DNA-depen- dent DNA synthesis mode (copying minus-strand DNA, syn- thesizing plus-strand DNA) preferentially substitutes A’s for other bases, this could introduce ... See full document
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Expression of human immunodeficiency virus type 1 reverse transcriptase in trans during virion release and after infection.
... BRL, Gaithersburg, Md.). The HeLa-CD4-LTR/ b -Galactosidase cell line (HCB) was obtained from M. Emerman through the AIDS Research and Reference Reagent Program, Division of AIDS, National Institute of Allergy and ... See full document
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Sensitive Phenotypic Detection of Minor Drug Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Variants
... cotransforming S. cerevisiae with known mix- tures of HIV-1 RT domains and a TyHRT vector from which part of the HIV-1 RT region was ...and reverse transcription of TyHRT elements result in ... See full document
9
Characterization and Structural Analysis of Novel Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involved in the Regulation of Resistance to Nonnucleoside Inhibitors
... in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase which are involved in the regulation of resistance to nonnucleoside reverse ... See full document
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