[PDF] Top 20 Retinoic acid signalling during development
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Retinoic acid signalling during development
... Although there has been tremendous progress in characterising the numerous developmental events regulated by the retinoid pathway, many gaps remain with respect to the underlying mechanisms of RA-mediated patterning. It ... See full document
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Wt1 controls retinoic acid signalling in embryonic epicardium through transcriptional activation of Raldh2
... a retinoic acid (RA) receptor-dependent ...retinoid signalling in the heart, the molecular mechanisms controlling cardiac Raldh2 transcription remain ...RA signalling via direct activation of ... See full document
5
Retinol dehydrogenase 10 is a feedback regulator of retinoic acid signalling during axis formation and patterning of the central nervous system
... process during early development of the central nervous ...Three signalling pathways, including retinoic acid, fibroblast growth factor and Wnt, contribute to the transforming signal ... See full document
12
Lens regulated retinoic acid signalling controls expansion of the developing eye
... embryonic retinoic acid synthesis (Sandell et ...that retinoic acid signalling may be impaired in lens-removed ...of retinoic acid levels is essential for normal eye ... See full document
13
Pulmonary vascular development in congenital diaphragmatic hernia
... factors, retinoic acid signalling has been shown to be important in lung development ...[17]. Retinoic acid is formed from vitamin A through several sequential enzymatic ...the ... See full document
6
Retinoic acid signalling specifies intermediate character in the developing telencephalon
... classes during forebrain and craniofacial development have made it difficult to establish the precise role(s) of individual signals in the early development of the telencephalon, and to resolve ... See full document
10
Abnormalities of somite development in the absence of retinoic acid
... The small, but perfectly formed somites we have seen here are a fascinating example of global regulation –achieving constant num- bers or proportions of a developmental unit despite large variations in total body size. ... See full document
9
CYP26 function is required for the tissue specific modulation of retinoic acid signaling during amphioxus development
... The expression of the three amphioxus CYP26 genes (CYP26- 1, CYP26-2, and CYP26-3) has previously been described in B. lanceolatum embryos and larvae (Carvalho et al., 2017). It has thus been shown that transcription of ... See full document
16
CHD7 represses the retinoic acid synthesis enzyme ALDH1A3 during inner ear development
... Overexpression of CHD7 inhibits ALDH1A3 expression in human cells. Because loss of Chd7 affected expres- sion of several RA signaling genes, we asked whether overexpression of CHD7 would have the opposite effect on those ... See full document
20
Retinoic acid and TGF-β signalling cooperate to overcome MYCN-induced retinoid resistance
... To identify novel ITRs which may enhance the clinical re- sponse to RA when given as combination therapies, we next collated ITRs which were strongly differentially regulated between the three conditions (Fig. 4d). One ... See full document
22
SHH propagates distal limb bud development by enhancing CYP26B1 mediated retinoic acid clearance via AER FGF signalling
... AER-FGF/CYB26b1/RA signalling module is already established during initiation of limb bud ...AER-FGF signalling due to the sequential activation of Fgf8, Fgf4, Fgf9 and Fgf17 regulates the expansion ... See full document
11
Correction to: Stemness marker ALDH1A1 promotes tumor angiogenesis via retinoic acid/HIF-1α/VEGF signalling in MCF-7 breast cancer cells
... Fig. 3 MCF-7 ALDH1A1 regulates angiogenic factor output via retinoic acid signalling. a Angiogenic factors release evaluated by ELISA plate array in supernatants of MCF-7 treated with CM037 (1 μ M) ... See full document
5
Retinoic acid has the potential to suppress endometriosis development
... reduced retinoic acid concentrations are observed in endometriotic lesions [18], and we previously reported that the HSD17B2 expression is suppressed in choESC accom- panied by aberrant DNA methylation ... See full document
7
Characterisation of chicken RXR-γ
... OF RETINOIC ACID ON HINDBRAIN DEVELOPMENT As stated in section ...of retinoic acid can have dramatic effects on the development of the central and peripheral nervous systems ... See full document
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Retinoic acid orchestrates fibroblast growth factor signalling to drive embryonic stem cell differentiation
... differentiation. Signalling via the fibroblast growth factor (Fgf)/Erk pathway is required to progress from this dynamic state and promote mouse ES cell ...differentiation. Retinoic acid also induces ... See full document
10
Retinoic acid synthesis and functions in early embryonic development
... kidney field is derived from the intermediate mesoderm. The specification of renal progenitor cells is influenced by RA signals emanating from the paraxial mesoderm [153-155]. Recent studies in Xenopus and zebrafish have ... See full document
14
Stage dependent responses of the developing lung to retinoic acid signaling
... place during the pseudoglandular stage and establishes the primitive conducting airways and presumptive terminal sacs, and (iii) alveologenesis, characterized by septation of the terminal sacs to form definitive ... See full document
6
Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue
... The data presented here demonstrates that FEN can increase dihydroceramide and dihydrosphingomyelin lipid species inde- pendently of RAR-signalling, which is associated with activation of cellular stress responses ... See full document
12
Characterization of cDNAs encoding two chick retinoic acid receptor alpha isoforms and distribution of retinoic acid receptor alpha, beta and gamma transcripts during chick skin development
... Int J De, BioI 39 587 596 (1995) Original Article Characterization of cDNAs encoding two chick retinoic acid receptor a isoforms and distribution of retinoic acid receptor a, Band y transcripts during[.] ... See full document
10
Early mouse caudal development relies on crosstalk between retinoic acid, Shh and Fgf signalling pathways
... The downregulation of Shh target genes in Raldh2 –/– mutants suggests that cells require RA during late gastrulation and early neurulation to respond properly to the Shh signal. Should it be the case, ... See full document
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