[PDF] Top 20 Retinoid X Receptor Antagonists
Has 10000 "Retinoid X Receptor Antagonists" found on our website. Below are the top 20 most common "Retinoid X Receptor Antagonists".
Retinoid X Receptor Antagonists
... Retinoid X receptor (RXR) antagonists are not only useful as chemical tools for biological research, but also are candidate drugs for treatment of various diseases, including diabetes and ... See full document
24
The retinoic acid receptor-α modulators ATRA and Ro415253 reciprocally regulate human IL-5+ Th2 cell proliferation and cytokine expression
... acid receptor alpha; RXR: Retinoid X receptor; PBMC: Peripheral blood mononuclear cells; HDM: House dust mite; Ag: Antigen; APC: Antigen presenting cells; TCR: T cell receptor; CTV: ... See full document
12
Vitamin D receptor, Retinoid X receptor and peroxisome proliferator-activated receptor γ are overexpressed in BRCA1 mutated breast cancer and predict prognosis
... Immunoreactivity of estrogen receptor (ER), progester- one receptor (PR) or Her2 in breast cancer tissue pro- vides both predictive and prognostic information. Determination of ER, PR and Her2 has evolved ... See full document
11
Effect of a retinoid X receptor partial agonist on airway inflammation and hyperresponsiveness in a murine model of asthma
... The levels of IL-5 and IL-13 in the culture supernatant in OVA-re-stimulated lung MNCs isolated from OVA-sensitized and -challenged mice were significantly suppressed in OVA/OVA/NEt-4IB [r] ... See full document
10
Retinoid X receptor and peroxisome proliferator activated receptor gamma agonists cooperate to inhibit matrix metalloproteinase gene expression
... acid, X is any amino acid, and K is the specific SUMOylation target) within PPAR has been confirmed [14,27], and Floyd and col- leagues [27] describe multiply SUMOylated forms of ...of receptor activity ... See full document
16
Dual targeting of retinoid X receptor and histone deacetylase with DW22 as a novel antitumor approach
... for the indicated time periods as described previously. Western blotting was performed as previously described [30]. Briefly, an equal amount of total protein extracts from cultured cells or tissues were fractionated by ... See full document
16
Studies of the expression and function of the retinoid-x-receptor y gene in rodent embryonic development
... R X R y is expressed prior to differentiation during the early stages of myogenesis because the Myf-5 gene, which is coexpressed with RXRy, is expressed prior to, as well as after the initiation of skeletal muscle ... See full document
304
Epigenomic signatures in liver and blood of Wilson disease patients include hypermethylation of liver-specific enhancers
... Results: WGBS analyses in liver identified 969 hypermethylated and 871 hypomethylated differentially methyl‑ ated regions (DMRs) specifically identifying patients with WD, including 18 regions with genome‑wide ... See full document
16
High Resolution X-ray Diffraction Analysis of CB1 Receptor Antagonists as a Means to Explore Binding Affinity
... the x-axis (negative in the negative range of x and positive in the positive range of x), the second about the y-axis, and the third about the ...the x-dipoles and y-dipoles are not refined, ... See full document
137
Silencing Retinoid X Receptor Alpha Expression Enhances Early-Stage Hepatitis B Virus Infection In Cell Cultures
... farnesoid X receptor (FXR), hepatocyte nuclear factor 4 ␣ (HNF-4 ␣ ), peroxisome proliferator-activated receptor alpha (PPAR ␣ ), retinoid X receptor alpha (RXR ␣ ), and ... See full document
20
The synthesis of potential steroid receptor antagonists
... the combined organic extracts were washed with distilled water 3 x 250 ml, dried over anhydrous magnesium sulphate, filtered under reduced pressure and evaporated to dryness under reduce[r] ... See full document
192
Retinoid X receptor alpha transactivates the hepatitis B virus enhancer 1 element by forming a heterodimeric complex with the peroxisome proliferator-activated receptor.
... P]ATP in the presence of T4 polynucleotide kinase. Following the DNA-protein binding reaction, certain samples were further incubated for 10 min at 48C in the presence of polyclonal antibody. For DNA competition ... See full document
5
Retinoid X receptor alpha is a spatiotemporally predominant therapeutic target for anthracycline-induced cardiotoxicity
... tion of two large-scale human genetic studies revealed rs2229774 [retinoic acid receptor (RARG)] and rs28714259 (intergenic region) as two susceptible variants to AIC (9, 10). Through a GWAS analysis of decline ... See full document
15
Proteasomal degradation of retinoid X receptor α reprograms transcriptional activity of PPARγ in obese mice and humans
... It has been postulated that the tissue-specific recruitment of nuclear coactivators by specific agonists influences PPARγ tran- scriptional activity, a mechanism by which side effects triggered in TZD target tissues, ... See full document
16
<p>Synergistic effect of a retinoid X receptor-selective ligand bexarotene and docetaxel in prostate cancer</p>
... Cyclin D1 is involved in G1/S transition, 21 but the results of cell cycle analysis showed no DTX-induced G1/S arrest, suggesting an insigni fi cant role for cyclinD1 in the combination t[r] ... See full document
10
Identification and Characterization of Human Genomic Binding Sites for Retinoic Acid Receptor/Retinoid X Receptor Heterodimers
... [31] Ponomarenko, J.V., Orlova, G.V., Merkulova, T.I., Gorshkova, E.V., Fokin, O.N., Vasiliev, G.V., Frolov, A.S. and Ponomarenko, M.P. (2002) rSNP Guide: An Integrated Database-Tools System for Studying SNPs and ... See full document
15
A retinoid X receptor (RXR) selective retinoid reveals that RXR α is potentially a therapeutic target in breast cancer cell lines, and that it potentiates antiproliferative and apoptotic responses to peroxisome proliferator activated receptor ligands
... The dUTP nick-end labeling (TUNEL) assay for in situ cell death detection was performed using a commercially avail- able kit (Roche Molecular Biochemicals, Indianapolis, IN, USA). Cells were treated with 0.1% dimethyl ... See full document
10
A retinoid X receptor partial agonist attenuates pulmonary emphysema and airway inflammation
... potential in animal models of type-2 diabetes [10], Alzheimer ’ s disease [11], and Parkinson ’ s disease [12]. However, bexarotene has various strong adverse events, such as weight gain, hepatomegaly, ... See full document
14
Regulation of lipid metabolism-related gene expression in whole blood cells of normo- and dyslipidemic men after fish oil supplementation
... liver X receptors [16], retinoid X receptor (RXR) [17], farnesoid X receptor [18], and per- oxisome proliferator-activated receptors (PPARs) [19], resulting in an altered ... See full document
10
Cholesterol Metabolism and Its Regulation by Functional Foods
... the retinoid X receptor tivated by a variety of sterols intermediaries and produce an expression of lipogenic genes and high speed of LXR functions as a sensor for and promotes its excretion and when ... See full document
11
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