[PDF] Top 20 Robust Gag specific T cell responses characterize viremia control in HIV 2 infection
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Robust Gag specific T cell responses characterize viremia control in HIV 2 infection
... between HIV-2– s p e c i f i c I F N -γ i m m u n e response magnitude and HIV-2 plasma ...(B) Gag-specific immune respons- es and VL (Spearman’s rank ...of responses in ... See full document
9
Rapid development of HIV elite control in a patient with acute infection
... CD8+ T cell subset differentiation (CD45RA; CCR7), activation (CD69; HLA- DR/CD38), immune checkpoint (PD-1) and CCR5 expres- sion prior to and following initiation of ART (September 2016 and November ... See full document
6
Enhanced Anti-HIV Functional Activity Associated with Gag-Specific CD8 T-Cell Responses
... Effective HIV-specific T-cell immunity requires the ability to inhibit virus replication in the infected host, but the functional characteristics of cells able to mediate this effect are not ... See full document
10
Human Immunodeficiency Virus Type 1 Escapes from Interleukin-2-Producing CD4+ T-Cell Responses without High-Frequency Fixation of Mutations
... these responses to protect from disease ...at Gag amino acid position 167 in the FRDYVDR FYKT epitope at a frequency of 1/21 at 5 months postinfection and was maintained at a frequency of 1/10 at 7 months ... See full document
11
Gag-Specific CD4+ T-Cell Frequency Is Inversely Correlated with Proviral Load and Directly Correlated with Immune Activation in Infection with Human Immunodeficiency Virus Type 2 (HIV-2) but Not HIV-1
... cytokine-producing HIV-specific CD4 subset to each individual’s response was also ...of HIV-2 ROD Gag (prepared by MRC, United Kingdom), and 15-mers, overlapping by 11 residues and ... See full document
5
Higher Homologous and Lower Cross-Reactive Gag-Specific T-Cell Responses in Human Immunodeficiency Virus Type 2 (HIV-2) Than in HIV-1 Infection
... the HIV-2-infected patient group consisted of patients enrolled in Senegal and Belgium, while all included HIV-1-infected patients were from ...HLA-restricted T-cell responses, ... See full document
10
Cooperativity of HIV-Specific Cytolytic CD4 T Cells and CD8 T Cells in Control of HIV Viremia
... ⫹ T cells dramatically expand during acute HIV infection, tightly following the viral load ...⫹ T cells during acute ...⫹ T cells is inversely correlated with HIV progres- sion, ... See full document
12
Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection
... of HIV-1 ...progressive infection from those with nonprogressive infection (1, 6), the ability of CD8 T cells to proliferate to viral antigen seems to be reserved to those persons with ... See full document
11
Role of Human Immunodeficiency Virus (HIV)-Specific T-Cell Immunity in Control of Dual HIV-1 and HIV-2 Infection
... HIV-2 infection) (33). HIV-1-infected subjects with the ability to respond to HIV-2 Gag, as well as HIV-1 protein products had lower HIV-1 plasma viral loads ... See full document
11
Cd8+ T Cell Effector Function And Transcriptional Regulation During Hiv Pathogenesis
... + T cells (Migueles et ...+ T cells from the group of CPs studied here should provide superior control over HIV ...+ T cells and viral loads in CPs suggests a different relationship ... See full document
154
Strong Human Endogenous Retrovirus-Specific T Cell Responses Are Associated with Control of HIV-1 in Chronic Infection
... ⫹ T cell responses (see Table S1 in the supplemental ...HERV-K Gag and Env peptides (JPT Peptide Technologies, Berlin, Germany) was also used to comprehensively map one elite controller’s ... See full document
9
Multifunctional Human Immunodeficiency Virus (HIV) Gag-Specific CD8+ T-Cell Responses in Rectal Mucosa and Peripheral Blood Mononuclear Cells during Chronic HIV Type 1 Infection
... Multifunctional HIV-specific CD8 ⴙ T cells are found in both the rectum and peripheral ...complex HIV-1-specific T-cell response patterns in both mucosal MNC and ...to ... See full document
12
Control of HIV-1 Pathogenesis in Viremic Nonprogressors Is Independent of Gag-Specific Cytotoxic T Lymphocyte Responses
... (HIV) infection leads to a progressive reduction on CD4 ⫹ T lymphocytes, which finally results in the development of AIDS-defining ...(1, 2). However, the termed HIV-1 viremic ... See full document
10
Hepatitis C Virus-Multispecific T-Cell Responses without Viremia or Seroconversion among Egyptian Health Care Workers at High Risk of Infection
... (HCV) infection is a global health problem (12, 31), with the highest worldwide disease prevalence re- ported in Egypt: 15% of the general population (14, 45, ...chronic infection (5) and only 15 to 50% ... See full document
7
HIV Infection Functionally Impairs Mycobacterium tuberculosis-Specific CD4 and CD8 T-Cell Responses
... CD8 T-cell responses (37–39), leading to persistent sub-clinical infections in most of immunocompetent individuals (40, ...CD4 T-cell frequencies, cytokine profiles, and phenotypes did ... See full document
18
Human Endogenous Retrovirus K(HML-2) Gag- and Env-Specific T-Cell Responses Are Infrequently Detected in HIV-1-Infected Subjects Using Standard Peptide Matrix-Based Screening
... ⫹ T-cell responses may be of lower avidity than those specific for exogenous viruses, such as HIV-1, as higher-avidity clones specific for HERV- K(HML-2) may have been ... See full document
5
Immunodominant HIV-Specific CD8+ T-Cell Responses Are Common to Blood and Gastrointestinal Mucosa, and Gag-Specific Responses Dominate in Rectal Mucosa of HIV Controllers
... ⴙ T-cell responses may be a correlate of protection in HIV ...Mucosal T-cell breadth and/or specificity may also contribute to defining protective ...ⴙ T-cell ... See full document
12
Induction of Gag-Specific CD4 T Cell Responses during Acute HIV Infection Is Associated with Improved Viral Control
... cell responses decreased in half (6/12) of these participants, the breadth increased in five and remained stable in ...of HIV-specific CD4 T cell responses significantly ... See full document
10
HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses
... of HIV-specific CD4 ⫹ T cells in the develop- ment of antibody neutralization breadth, we comprehensively as- sessed a cohort of 34 chronically HIV-infected controllers for cir- culating ex ... See full document
13
Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells
... the HIV Gag and Nef protein sequences. An unstimulated control and a positive control (Staphylococ- cus enterotoxin B) were included in each ...fluorescence-activated cell sorter buffer ... See full document
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