[PDF] Top 20 The role of CBP and p300 in cardiac hypertrophy
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The role of CBP and p300 in cardiac hypertrophy
... Interestingly, CBP is found in association with both ACTR and P/CAF, and the simultaneous recruitment o f these proteins in large multi-protein complexes appears to be necessary for activation o f transcription ... See full document
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Developmentally regulated expression of the transcriptional cofactors/histone acetyltransferases CBP and p300 during mouse embryogenesis
... ABSTRACT CBP (CREBBP/ CREB-binding protein) and p300 are related signal-dependent transcriptional cofactors and histone ...human CBP gene have been found in Rubinstein-Taybi syndrome (RTS), which is ... See full document
8
CBP/p300 is a cell type-specific modulator of CLOCK/BMAL1-mediated transcription
... that p300 has an effect similar to CBP on transcriptional regulation (31-33, 40), several other reports have noted differences in the activities of p300 and CBP ...that p300, but not ... See full document
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Role of infectious agents in the carcinogenesis of brain and head and neck cancers
... CBP/p300: CREB binding protein/p300; 0CMV: Cytomegalovirus; COX-2: Cyclooxygenase 2; SV40: Simian virus 40; BKV: BK virus; JCV: John Cunningham virus; EBER: Epstein-Barr virus-encoded small RNA; ... See full document
9
Spatiotemporal expression of histone acetyltransferases, p300 and CBP, in developing embryonic hearts
... that p300 and CBP are essential for multi-orga- nogenesis [8-14], little is known about their locations and dynamic expression in the heart during the ...the cardiac crescent forming at ...both ... See full document
10
CREB-Binding Protein and Histone Deacetylase Regulate the Transcriptional Activity of Kaposi's Sarcoma-Associated Herpesvirus Open Reading Frame 50
... to CBP/p300 and HDAC1 and these transcriptional cofactors modulated the transcriptional activation function of ...with CBP and HDAC1 is determined by the relative concentration of each protein in ... See full document
9
Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes.
... of CBP have also been shown to bind to a glutathione S-transferase– TFIIB full-length fusion protein in vitro ...one role of CBP is to convey an upstream transcription signal to the basal tran- ... See full document
6
The prognostic capacities of CBP and p300 in locally advanced rectal cancer
... in CBP and/or p300 is consid- ered to be associated with tumourigenesis in several human malignancies, their roles in CRC remain unclear and somewhat ...of CBP and p300 in patients with rectal ... See full document
8
Characterization of an E1A-CBP Interaction Defines a Novel Transcriptional Adapter Motif (TRAM) in CBP/p300
... target CBP/p300 and can interact directly with CBP amino acids 1808 to 1826 ...of CBP (9a) and down-regulates p53-dependent transcription (32a), it is likely that all three of these small DNA ... See full document
8
Structure of noncoding RNA is a determinant of function of RNA binding proteins in transcriptional regulation
... with CBP/p300 was induced by ncRNAs that bind to TLS, and this in turn results in inhibition of CBP/p300 histone acetyltransferase (HAT) activity in human ... See full document
8
A CRISPR Interference of CBP and p300 Selectively Induced Synthetic Lethality in Bladder Cancer Cells In Vitro
... of CBP in these ...of CBP for the low activity of hTERT promoter in SV-HUC1 ...suppress p300 mRNA levels in 5637, T24 and SV-HUC1 cells ...of CBP and p300 in 5637 and T24 cells ...of ... See full document
11
Curcumin prevents and reverses murine cardiac hypertrophy
... critical role in the progression of pathologi- cal cardiac hypertrophy and heart ...suppress cardiac hyper- trophy through the disruption of p300 histone acetyltransferase–dependent ... See full document
16
CBP/p300 and associated transcriptional co activators exhibit distinct expression patterns during murine craniofacial and neural tube development
... - CBP, p300, Cited2, Cart1 and Carm1 - result in neural tube defects in ...of CBP/p300 and associated transcriptional co- activators, Cited2, Cart1 and Carm1 during the period of murine neural ... See full document
9
The E6 Protein of the Cutaneous Human Papillomavirus Type 8 Can Stimulate the Viral Early and Late Promoters by Distinct Mechanisms
... using p300 (38, 50, ...and p300, which we correlated with a cooperative activation of HPV8 gene expression ...the role of 8E6 on the functional interaction between 8E2 and p300 in activation ... See full document
11
Transcriptional Coactivators Are Not Required for Herpes Simplex Virus Type 1 Immediate-Early Gene Expression In Vitro
... to p300 and CBP, other HATs such as PCAF and GCN5 are known to interact with the AD of VP16 (68, ...for p300 and CBP, IE gene expression was not affected significantly under most circumstances ... See full document
14
Original Article Expression of p300 and CBP is associated with poor prognosis in small cell lung cancer
... for CBP, and human lung adenocarcinoma tissue sections for ...of p300, CBP and MLL was scored following a semi-quantitative scale by evaluating representative tumor areas, intensi- ty and percentage ... See full document
8
Green tea polyphenol treatment is chondroprotective, anti inflammatory and palliative in a mouse posttraumatic osteoarthritis model
... Results: Four and eight weeks after DMM surgery, the cartilage in EGCG-treated mice exhibited less Safranin O loss and cartilage erosion, as well as lower OARSI scores compared to vehicle-treated controls, which was ... See full document
11
Transcription factors: Are they a real target for future therapeutic strategies?
... acetyltransferase CBP/p300 and the transcription factors CCAAT/enhancer binding protein (C/EBP), nuclear factor – AT (NF-AT) AP-1 controls the expression of the asthma associated cytokine IL-5 and can be ... See full document
22
Inhibition of endogenous thioredoxin in the heart increases oxidative stress and cardiac hypertrophy
... induces cardiac hypertrophy under basal conditions and enhances car- diac hypertrophy in response to pressure ...between cardiac myocytes and smooth muscle cells, it is possible that VDUP1 has ... See full document
13
Post transcriptional control of the epigenetic stem cell regulator PLZF by sirtuin and HDAC deacetylases
... protein; CBP/p300: CREB binding protein/p300 protein; CD34: cluster of differentiation 34; ChIP: chromatin immunoprecipitation; c‑myc: myc transcription factor; CpG: cytosine‑phosphate‑guanidine; ... See full document
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