[PDF] Top 20 Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1.
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Role of CD4 epitopes outside the gp120-binding site during entry of human immunodeficiency virus type 1.
... for human immunodeficiency virus (HIV). The binding site for the surface glycoprotein of HIV type 1 (HIV-1), gp120, has been mapped to the C * -C ( region of ... See full document
9
Neutralizing antibodies against the V3 loop of human immunodeficiency virus type 1 gp120 block the CD4-dependent and -independent binding of virus to cells.
... The CD4 molecule is an essential receptor for human immunodeficiency virus type 1 (HIV-1) through high-affinity interactions with the viral external envelope glycoprotein ... See full document
10
Determinants of human immunodeficiency virus type 1 entry in the CDR2 loop of the CD4 glycoprotein.
... of CD4 that are positioned proximal to the gp120 binding site (2, 3, 9, 12, 33, ...and gp120 binding affinity could explain the recep- tor capability of the mutant CD4 ... See full document
6
Enhanced Exposure of the CD4-Binding Site to Neutralizing Antibodies by Structural Design of a Membrane-Anchored Human Immunodeficiency Virus Type 1 gp120 Domain
... the human immunodeficiency virus type 1 (HIV-1) gp120 envelope (Env) ...by CD4-binding-site (CD4-BS) antibodies, membrane-anchored ODs were ... See full document
10
Interaction with CD4 and Antibodies to CD4-Induced Epitopes of the Envelope gp120 from a Microglial Cell-Adapted Human Immunodeficiency Virus Type 1 Isolate
... monomeric gp120 proteins with CD4 or 17b. Equilibrium binding analyses showed no difference between Bori and Bori-15 ...real-time binding experiments showed that while both proteins have ... See full document
11
CD4 Binding Site Antibodies Inhibit Human Immunodeficiency Virus gp120 Envelope Glycoprotein Interaction with CCR5
... sponse during natural infection (4–6); however, the elicitation of broadly reactive neutralizing antibodies is ...conserved gp120 neutralization epitopes consist of regions near the ... See full document
6
Conformational changes affecting the V3 and CD4-binding domains of human immunodeficiency virus type 1 gp120 associated with env processing and with binding of ligands to these sites.
... Monoclonal antibodies MAbs that compete for binding of gpl20 to CD4 have been previously described; these include antibodies directed against linear epitopes located within the C4 domain[r] ... See full document
6
Characterization of a novel binding site for the human immunodeficiency virus type 1 envelope protein gp120 on human fetal astrocytes.
... 2 nor recombinant soluble CD4 protein up to 8 ,ug/ml had Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest 1251_labeled recombinant gpl20 bound to primary cultures of huma[r] ... See full document
5
Amino-Terminal Substitutions in the CCR5 Coreceptor Impair gp120 Binding and Human Immunodeficiency Virus Type 1 Entry
... the human immu- nodeficiency virus type 1 (HIV-1) envelope glycoproteins to initiate viral entry into target cells (1, 11, 15, 17, 20, ...simian immunodeficiency ... See full document
7
Recognition properties of a panel of human recombinant Fab fragments to the CD4 binding site of gp120 that show differing abilities to neutralize human immunodeficiency virus type 1.
... 8 0022-538X/94/$04.00+0 Copyright © 1994, American Society for Microbiology Recognition Properties of a Panel of Human Recombinant Fab Fragments to the CD4 Binding Site of gpl20 That Sho[r] ... See full document
8
Involvement of the V1/V2 variable loop structure in the exposure of human immunodeficiency virus type 1 gp120 epitopes induced by receptor binding.
... The binding of human immunodeficiency virus type 1 (HIV-1) to the cellular receptor CD4 has been suggested to induce conformational changes in the viral envelope ... See full document
11
Dynamic features of the selective pressure on the human immunodeficiency virus type 1 (HIV 1) gp120 CD4 binding site in a group of long term non progressor (LTNP) subjects
... replicating virus from all subjects, differences were observed between NPs and ...responses during the different phases of HIV-1 infection (or the different patterns of disease progression ...the ... See full document
15
Enhanced Exposure of Human Immunodeficiency Virus Type 1 Primary Isolate Neutralization Epitopes through Binding of CD4 Mimetic Compounds
... the binding of both CD4i MAbs 17b and 4C11 increased remarkably after pretreatment with 100 M NBD-556 (the MFIs increased from ...the binding of all of the anti-V3 MAbs—KD-247, 3E4, and ...the ... See full document
11
Structure of the Fab Fragment of F105, a Broadly Reactive Anti-Human Immunodeficiency Virus (HIV) Antibody That Recognizes the CD4 Binding Site of HIV Type 1 gp120
... (CD4 binding loop, red/yellow triangle) is straddled by a cleft between CDR H3 and CDR H1&2, and the light chain interacts with gp120 D-loop residues (orange oval, behind the plane of the ... See full document
10
Immunization with a soluble CD4-gp120 complex preferentially induces neutralizing anti-human immunodeficiency virus type 1 antibodies directed to conformation-dependent epitopes of gp120.
... Conformational epitope on gpl20 important in CD4 binding and human immunodeficiency virus type 1 neutralization identified by a human monoclonal antibody.. Broadly neutralizing antibodie[r] ... See full document
9
Nonneutralizing Antibodies to the CD4-Binding Site on the gp120 Subunit of Human Immunodeficiency Virus Type 1 Do Not Interfere with the Activity of a Neutralizing Antibody against the Same Site
... of human immunodeficiency virus type 1 (HIV-1) involves the binding of antibodies to the native, fu- sion-competent envelope glycoprotein (Env) complex on the surface of ... See full document
8
Discontinuous, conserved neutralization epitopes overlapping the CD4-binding region of human immunodeficiency virus type 1 gp120 envelope glycoprotein.
... 9 Discontinuous, Conserved Neutralization Epitopes Overlapping the CD4-Binding Region of Human Immunodeficiency Virus Type 1 gpl20 Envelope Glycoprotein Received 6 March 1992/Accepted 1 [r] ... See full document
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Antigenic Variation within the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120: Effects on Chemokine Receptor Utilization
... expressing gp120 ORFs of several molecularly cloned laboratory-adapted viruses maintain the tropism of the gp120-derived clone and demonstrate the same sensitivity to neutralizing agents as the ... See full document
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Fine Mapping of the Interaction of Neutralizing and Nonneutralizing Monoclonal Antibodies with the CD4 Binding Site of Human Immunodeficiency Virus Type 1 gp120
... monomeric gp120 of human immunodeficiency virus type 1 to systematically identify residues important for gp120 recognition by neutralizing and nonneutralizing monoclonal ... See full document
17
Discovery of Small-Molecule Human Immunodeficiency Virus Type 1 Entry Inhibitors That Target the gp120-Binding Domain of CD4
... the gp120-CD4 in- teraction involves relatively small contact surface areas on both ...HIV-1 gp120 core com- plexed with an N-terminal two-domain CD4 (D1/D2 CD4) and a Fab ... See full document
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