[PDF] Top 20 Roles of p53 in Herpes Simplex Virus 1 Replication

... expressed herpes simplex virus 1 (HSV-1) regulatory protein ICP22 coupled with mass spectrometry-based proteomics technology and subsequent analyses showed that ICP22 interacted with ... See full document

... Alanine replacement of one of the identified phosphorylation sites in UL51, serine 184 (Ser-184), but not the other identified phosphorylation sites, significantly re- duced viral replication and cell-cell spread in ... See full document

... DISCUSSION Virus replication can begin only after the viral genome has been delivered to a site capable of supporting the production of viral gene products and replication of the viral ...The ... See full document

... affects virus replication and eye disease in ocularly infected mice (9, ...The roles of M1 and M2 macrophages in protective responses and disease are not universal, however, and may depend on both ... See full document

... ical roles in a wide variety of biological processes, ranging from regulation of enzymes by intramolecular interactions to in- creasing the local concentration or altering the subcellular localization of ... See full document

... The DHCR24 ⫺/⫺ and DHCR24 ⫹/⫹ cell system allows evaluation of the hydrocarbon tail of cholesterol in HSV entry and in the replicative cycle using a drug-free system. We hypothesized that cell cholesterol is essential ... See full document

... possible roles of RPA during HSV infection. ATR also plays negative roles during HSV-1 ...in virus yield. When ATR was activated prior to infec- tion, virus yields were unaffected; ... See full document

... DNA replication, it causes a conformational change at the replication fork that then allows recruitment of PML to the viral ...two roles in the development of HSV-1 replication ...the ... See full document

... viral replication in the eyes at 4 days postinfec- tion and in the brains at 3 and 4 days ...viral replication in the trigeminal ganglia caused by the preclusion of Us8A Ser-61 phosphorylation may lead to ... See full document

... of p53 metabolism are affected during HSV-1 infec- tions of cultured ...on p53 vary between different cell types, implying that viral gene expression modulates several pathways that impinge upon ... See full document

... eIF2 ␣ and allow protein synthesis to proceed in the presence of activated PKR enables HSV-1 to replicate efficiently in MEFs. ICP34.5 can also decrease the numbers of autophago- somes and numbers of virions ... See full document

... Abstract Herpes simplex virus - 1 (HSV-1) is a common human double-stranded DNA virus that can cause a variety of pathologies, including recurrent oral lesions in the ... See full document

... to replication of a virus or viral ...oncolytic virus, reduced replication capability would be expected to be directly reflected in lower oncolytic ...wild-type virus and an attenuated ... See full document

... It is also possible that early gene expression in cells infected by HSV-1 strains which have an intact IE 3 gene contributes to the induction of CPE, particularly since IE 3-expressing s[r] ... See full document

... with herpes simplex virus type 1 (HSV-1) results in the rapid elimination of mitochondrial DNA (mtDNA) from host ...viral replication or the biology of HSV-1 in- ...viral ... See full document

... in herpes simplex virus 1-infected cells, ICP22 upregulates the accumulation of a subset of ␥ 2 proteins exemplified by the products of the U L 38, U L 41, and U S 11 ...infectious ... See full document

... Recently, a method has been developed to identify regions in the genome of herpes simplex virus type 1 (HSV-1) which contain genes required for DNA synthesis from an HSV-1 origin of DNA [r] ... See full document

... DNA replication our data shows that gamma2- genes produce a transcription-complex that recruits ...beta-free virus using bacterial artificial chromosomes and complementing them with stably transfected ... See full document

... The hydrophobic residues in the NES are important for nuclear export of VP19C, and VP19C is exported from the nucleus through the NES via a CRM1-dependent pathway. However, CRM1-mediated transport is highly subjected to ... See full document

... HSV-1 replication but not gene expres- ...DNA replication, we examined in- fections in cells treated with the drug phosphonoacetic acid (PAA), a specific inhibitor of the viral ...DNA ... See full document