[PDF] Top 20 Simian virus 40 gene A function and maintenance of transformation.
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Simian virus 40 gene A function and maintenance of transformation.
... The procedures for obtaining cells from embryos of CDF albino inbred 6:36 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Transformants have been isolated after infecti[r] ... See full document
9
Role of simian virus 40 gene A function in maintenance of transformation.
... During infection of susceptible monkey cells at the restrictive temperature, group A mutants synthesize SV40 tumor T antigen and stimulate host cell DNA replication, but fail to produce [r] ... See full document
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Adenovirus type 12 gene 401 function and maintenance of transformation.
... The ts401-transformed 3Y1 cells, but not the wild-type transformants, displayed a temperature-sensitive response with respect to the following characteristics of the transformed phenotyp[r] ... See full document
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A novel translational regulation function for the simian virus 40 large-T antigen gene.
... from virus infection ex- periments, as shown in ...VAI gene) or sub720 (lacking both the VA genes) displayed the translational defect characteristic of the VA-negative mutants ...large-T gene cloned ... See full document
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MDM2 is a target of simian virus 40 in cellular transformation and during lytic infection.
... postulated function of MDM2 as a negative regulator of ...transforming function for the targeting of MDM2 by ...SV40 transformation: metabolic stabilization of p53 enhances the fraction of LT in ... See full document
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Simian virus 40 small t antigen is not required for the maintenance of transformation but may act as a promoter (cocarcinogen) during establishment of transformation in resting rat cells.
... ii When growing cells were infected and then immediately plated on plastic at different cell densities ranging from low 1% confluence to high 100% confluence to score for dense foci see [r] ... See full document
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Expression of simian virus 40 gene A affects tubulin stability.
... In the search for possible effects of SV40 transformation on cytoskeletal proteins, in par47 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The stability of tubulins p[r] ... See full document
5
Stimulation of host centriolar antigen in TC7 cells by simian virus 40: requirement for RNA and protein syntheses and an intact simian virus 40 small-t gene function.
... Frequency of centriolar antigen staining in cells infected with SV40 early viable deletion mutants, adenovirus-SV40 hybrid viruses, or adenovirus 2a % of cells showing positive centrioCe[r] ... See full document
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Simian virus 40 in humans
... long-period maintenance of the origi- nal oncogenic agent that caused the injury and initiated the tumorigenesis ...explain transformation of human cells by the mutagenic herpesviruses [160,161], and has ... See full document
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Distinct transformation phenotypes induced by polyoma virus and simian virus 40 in rat fibroblasts and their control by an early viral gene function.
... Thus, all polyoma virus-transformed rat cells on one side exhibited a well-characterized transformed phenotype for any property which was assayed growth characteristics on solid substrat[r] ... See full document
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Simian virus 40 functions required for the establishment and maintenance of malignant transformation.
... Figure 2 shows that: i mock-infected confluent secondary CHL cells remained at low cell density in low serum at 40 C; ii adsorption with wild-type virions induced clones which overgrew t[r] ... See full document
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Function of simian virus 40 gene A in transforming infection.
... A A hamster embryo cell stably transformed by A58 at 33 C and then incubated in a dilute suspension of single cells for 2 weeks at 41 C without cell division; B formation of a transforme[r] ... See full document
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Temperature dependency for maintenance of transformation in mouse cells transformed by simian virus 40 tsA mutants.
... The great majority of mouse embryo fibroblast transformants generated with tsA mutant virus were temperature sensitive for transformation in all three assays, regardless of the input mul[r] ... See full document
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Growth state of the cell early after infection with simian virus 40 determines whether the maintenance of transformation will be A-gene dependent or independent.
... N-transformed rat cells were seeded at low density 2 x 104 cells per 25-cm2 flask, grown at 330C, and shifted to 40°C after 4, 7, 9, or 13 days when the cell populations were growing, at[r] ... See full document
10
Association of simian virus 40 T antigen with replicating nucleoprotein complexes of simian virus 40.
... Recently, Mann and Hunter 30 detected SV40 large T antigen in the fraction of a sucrose gradient containing mature 70S NPCs by immunoprecipitation of T antigen labeled with [3S]methionin[r] ... See full document
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Selectivity of interferon action in simian virus 40-transformed cells superinfected with simian virus 40.
... These data seem to imply that a block in viral uncoating cannot be the only mechanism by Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Experiments with SV40-transform[r] ... See full document
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Transformation of primary rat kidney cells by fragments of simian virus 40 DNA.
... Rescue of SV40 virus from transformed BRK cells by fusion with BSC-1 cells Transformed linea Appear- Ifciu ance of Infectious CPEb BRK SV form I BRK SV EcoRI linear BRK SV HpaII linear B[r] ... See full document
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Identification of the Simian Virus 40 Which Replicates When Simian Virus 40-Transformed Human Cells Are Fused with Simian Virus 40-Transformed Mouse Cells or Superinfected with Simian Virus 40 Deoxyribonucleic Acid
... We used mKS-U13 and mKS-BU100, ever, it was not possible to discern whether the which release large-clear plaque types of SV40h rescued SV40 was the progeny of the resident viral after f[r] ... See full document
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Association of Simian Virus 40 T Antigen with Simian Virus 40 Nucleoprotein Complexes
... To determine the functional significance of the SV40 lOOK T antigen in SV40 nucleoprotein complexes containing SV40 I DNA, cells were infected with SV40 tsA58, a temperature-sensitive mu[r] ... See full document
10
Cell killing by simian virus 40: impairment of membrane formation and function.
... Summary of time course of SV40 cytopathic effects Event Begins h Lysosomal enzyme release N-acetyl-f3-glucosaBefore 30 minidasea Mitochondrial enzyme release MDH Before 30 32-40 Cytoplas[r] ... See full document
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