[PDF] Top 20 Site-Specific Phosphorylation Regulates Human T-Cell Leukemia Virus Type 2 Rex Function In Vivo
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Site-Specific Phosphorylation Regulates Human T-Cell Leukemia Virus Type 2 Rex Function In Vivo
... analyses. Cell lysates were prepared at 24 h posttransfection in Passive Lysis Buffer (Promega, Madison, WI) with a protease inhibitor mixture (Roche Applied Science, Indianapolis, IN) on ice for 30 ...The ... See full document
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Human T-cell leukemia virus type 2 Rex inhibits pre-mRNA splicing in vitro at an early stage of spliceosome formation.
... HTLV-2 Rex can effectively inhibit splicing of RNAs containing a Rex RNA-binding element in ...that Rex binding to the RxRE in the 5 9 LTR has the potential of inhibiting viral RNA splicing in ... See full document
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Human T-Cell Leukemia Virus Type 2 Rex Carboxy Terminus Is an Inhibitory/Stability Domain That Regulates Rex Functional Activity and Viral Replication
... Human T-cell leukemia virus (HTLV) regulatory protein, Rex, functions to increase the expression of the viral structural and enzymatic gene ...The phosphorylation of two ... See full document
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Human T-Cell Leukemia Virus Type 1 Expressing Nonoverlapping Tax and Rex Genes Replicates and Immortalizes Primary Human T Lymphocytes but Fails To Replicate and Persist In Vivo
... Human T-cell leukemia virus type 1 (HTLV-1) is an oncogenic retrovirus associated primarily with adult T-cell leukemia and neurological ...and Rex, ... See full document
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Mutational analysis of human T-cell leukemia virus type 2 Tax.
... (Table 2). It is important to note that Tax-2 mutant T113-A does consis- tently maintain the capacity to transactivate the HTLV-1 LTR slightly (15% activity) (Table ...transactivating function ... See full document
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Involvement of Human CRM1 (Exportin 1) in the Export and Multimerization of the Rex Protein of Human T-Cell Leukemia Virus Type 1
... The Rex protein of human T-cell leukemia virus type 1 acts posttranscriptionally to induce the cytoplasmic expression of incompletely spliced or unspliced mRNAs encoding ... See full document
6
High-resolution mapping of the human T-cell leukemia virus type 1 Rex-binding element by in vitro selection.
... in vivo (10). Similarly, chemical modifications that influence Rex binding do not occur exclusively within the core; for example, modifi- cation of C-172 with hydrazine resulted in enhanced interac- tions ... See full document
11
Host Sequences Flanking the Human T-Cell Leukemia Virus Type 1 Provirus In Vivo
... of site-specific recombination by FLP recombinase ...for T at the second position, for A at the third and fourth positions, and for C at the fifth position (6, 41, ...or T residues at position ... See full document
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Human T-Cell Leukemia Virus Type 2 Rex Protein Increases Stability and Promotes Nuclear to Cytoplasmic Transport of gag/pol and env RNAs
... 40). Specific binding of Rex to the RxRE is correlated with function and is regulated by phos- phorylation (6, ...HTLV-1 Rex (Rex-1) function using stably infected cells or by ... See full document
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The human T-cell leukemia virus type 1 Rex regulatory protein exhibits an impaired functionality in human lymphoblastoid Jurkat T cells.
... The Rex protein of human T-cell leukemia virus type 1 (HTLV-1) intervenes in the posttranscriptional regulation of proviral gene ...the Rex response element (XRE) ... See full document
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Phosphorylation regulates human T cell leukemia virus type 1 Rex function
... The Rex-1 expression vector SE356, which contains the HTLV-1 tax/rex cDNA expressed from the cytomegalovirus (CMV) immediate-early gene promoter, was described previously ...S-tagged Rex-1 expression ... See full document
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Phosphorylation of Two Serine Residues Regulates Human T-Cell Leukemia Virus Type 2 Rex Function
... Human T-cell leukemia virus (HTLV) types 1 (HTLV-1) and 2 (HTLV-2) are complex retroviruses that have been caus- ally associated with leukemia and neurological ... See full document
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Inhibition of human T-cell leukemia virus type 2 Rex function by truncated forms of Rex encoded in alternatively spliced mRNAs.
... for virus replication and transformation in vitro ...in vivo analyses carried out on rabbits infected with HTLV-2 pointed out that the proximal part of the X region, which was previously shown to be ... See full document
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Secondary structure of the human T-cell leukemia virus type 1 rex-responsive element is essential for rex regulation of RNA processing and transport of unspliced RNAs.
... 6 0022-538Xt90/062825-08$02.00/0 Copyright C 1990, American Society for Microbiology Secondary Structure of the Human T-Cell Leukemia Virus Type 1 rex-Responsive Element Is Essential for[r] ... See full document
8
The tax gene of human T-cell leukemia virus type 2 is essential for transformation of human T lymphocytes.
... HTLV-induced T-cell transformation re- mains ...adult T-cell leukemia do so after a 25- to 30-year latent ...in T- cell growth and differentiation, which has led to a ... See full document
9
In Vivo Analysis of Human T-Cell Leukemia Virus Type 1 Reverse Transcription Accuracy
... selection. Cell clones were then transiently transfected with the helper ...step 2, vector virus was harvested 48 h posttransfection from step 1 cells and used to infect fresh CEM-A ...G418-resistant ... See full document
7
Rat CRM1 Is Responsible for the Poor Activity of Human T-Cell Leukemia Virus Type 1 Rex Protein in Rat Cells
... on Rex function. We investigated the capacity of rCRM1 to support Rex function relative to that of ...measured Rex activity in REF52 cells cotransfected with pDM128RxRE, pSR ␣ ... See full document
11
Human T-Cell Leukemia Virus Type 2 Antisense Viral Protein 2 Is Dispensable for In Vitro Immortalization but Functions To Repress Early Virus Replication In Vivo
... Tax function, we next evaluated this functional role of APH-2 in the context of the entire HTLV-2 proviral clone by generating two mutant proviral clones (HTLV-2⌬APH and ...The cell ... See full document
10
Phosphorylation of Human Immunodeficiency Virus Type 1 Vpr Regulates Cell Cycle Arrest
... one site at positions 94S or 96S was phosphory- lated, although neither pZY-VPr94S or pZY-Vpr96S could be ...96S phosphorylation or vice ...serine phosphorylation site was created by mutation ... See full document
8
Human T cell leukemia virus type 2 Tax protein induces interleukin 2 independent growth in a T cell line
... EL-4 T-cell line treated with (lane 2) or without (lane 1) 20 µg/ml phorbol myristate acetate and 1 µM ionomycin for 5 hours using RNAiso reagent, according to the manufacturer's instructions ... See full document
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