[PDF] Top 20 SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement
Has 10000 "SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement" found on our website. Below are the top 20 most common "SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement".
SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement
... the SOSIP Env was compared to the State 2/3-stabilized L193R and I423A Env mutants, we also observed major differences in ligand ...the SOSIP changes resulted in conforma- tions of the SOSIP ... See full document
14
Changes in the transmembrane region of the human immunodeficiency virus type 1 gp41 envelope glycoprotein affect membrane fusion.
... The presence of wild-type levels of gpl20 glycoprotein in the supernatants of COS-1 cells transfected with the plas- mids expressing the mutant envelope glycoproteins sug- gested that th[r] ... See full document
5
Effects of changes in gp120-CD4 binding affinity on human immunodeficiency virus type 1 envelope glycoprotein function and soluble CD4 sensitivity.
... To examine whether changes in the HIV-1 gpl20 glycoprotein previously shown to alter its affinity for CD4 (33) affected the temperature-dependent component of the binding process, the bi[r] ... See full document
6
Determinants of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Activation by Soluble CD4 and Monoclonal Antibodies
... YU2 envelope glycoproteins need to assume a confor- mation of high free energy to achieve an antibody-enhanceable state, the binding of any ligand to the glycoproteins could induce a return to a lower-energy ... See full document
7
Determinants of human immunodeficiency virus type 1 envelope glycoprotein oligomeric structure.
... on glycoprotein fusion function, CD4 binding, and gp120-gp41 ...env glycoprotein fusion func- tion. Figure 5 shows that while the wild-type env glycoprotein induced syncytia with up to ... See full document
10
Evaluation of the contribution of the transmembrane region to the ectodomain conformation of the human immunodeficiency virus (HIV 1) envelope glycoprotein
... Certain conformations of the HIV-1 Env trimer ecto- domains have been stabilized for structural analysis by the introduction of gp120 and gp41 changes, or selected by the binding of specific antibodies ... See full document
16
A Conformation-Specific Monoclonal Antibody Reacting with Fusion-Active gp41 from the Human Immunodeficiency Virus Type 1 Envelope Glycoprotein
... the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein plays a major role in the membrane fusion step of viral ...fusion-active conformation ... See full document
5
CD4-Induced Conformational Changes in the Human Immunodeficiency Virus Type 1 gp120 Glycoprotein: Consequences for Virus Entry and Neutralization
... 1998 Human immunodeficiency virus type 1 (HIV-1) entry into target cells involves sequential binding of the gp120 exterior envelope glycoprotein to CD4 and ... See full document
10
Reevaluation of the Requirement for TIP47 in Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Incorporation
... and virus lysates were immunoprecipitated with ...or virus release efficiency was observed ...not affect Env incorporation, virus release efficiency, or HIV-1 ... See full document
10
Determinants of human immunodeficiency virus type 1 entry in the CDR2 loop of the CD4 glycoprotein.
... receptor, CD4, have been proposed in facilitating human immunodeficiency virus type 1 (HIV-1) entry, including virion binding to the target cell and the induction of ... See full document
6
Identification of a Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Variant Resistant to Cold Inactivation
... promote virus entry. Surprisingly, we found that the envelope glycoproteins of some HIV-1 strains are functionally inactivated by prolonged incubation on ...temperature-resistant virus. The ... See full document
13
Mutagenic Stabilization and/or Disruption of a CD4-Bound State Reveals Distinct Conformations of the Human Immunodeficiency Virus Type 1 gp120 Envelope Glycoprotein
... of CD4-bound gp120 (95), suggesting that these antibodies might recognize distinct con- formations of ...a conformation that more closely resembled the CD4-bound ...the CD4-bound ... See full document
12
Activation and Inactivation of Primary Human Immunodeficiency Virus Envelope Glycoprotein Trimers by CD4-Mimetic Compounds
... ABSTRACT Human immunodeficiency virus type 1 (HIV-1) entry into cells is medi- ated by the viral envelope glycoproteins (Env), a trimer of three gp120 exterior gly- coproteins, ... See full document
20
Envelope Glycoprotein Incorporation, Not Shedding of Surface Envelope Glycoprotein (gp120/SU), Is the Primary Determinant of SU Content of Purified Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus
... the envelope glycoproteins (2, ...native envelope proteins to vaccine efficacy, it is essential that these proteins maintain functional and structural conformation and be re- tained on the ... See full document
11
Functional Pseudotyping of Human Immunodeficiency Virus Type 1 Vectors by Western Equine Encephalitis Virus Envelope Glycoprotein
... encephalitis virus envelope glycoproteins (WEEV GP) to pseudotype lentiviral ...GP-pseudotyped human immunodeficiency virus type 1 (HIV) ranged as high as ...to ... See full document
5
Stabilization of Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Trimers by Disulfide Bonds Introduced into the gp41 Glycoprotein Ectodomain
... gp160 glycoprotein. This glycoprotein was expressed efficiently on the cell surface and was precipitated by antibodies that recognize conformation-depen- dent gp120 epitopes (29, ...the ... See full document
6
Human immunodeficiency virus type 1 Vpu has a CD4- and an envelope glycoprotein-independent function.
... Because Vpu function was apparently not dependent on HIV-1 Env-gp expression, we wanted to determine whether the reduction in infectious virus produced by the vpu mutant could be due to [r] ... See full document
5
Envelope glycoprotein and CD4 independence of vpu-facilitated human immunodeficiency virus type 1 capsid export.
... The effect of vpu on the release of human immunodeficiency type 1 capsid proteins was examined in the presence or absence of virus-encoded envelope glycoproteins as well as in cells whic[r] ... See full document
8
Kinetics of soluble CD4 binding to cells expressing human immunodeficiency virus type 1 envelope glycoprotein.
... Figure 1 shows examples of flow cytometry data for CEM cells stained with FITC-conjugated OKT4 (Fig. 1A), unin- fected 12E1 (CD4-) cells incubated with sCD4 and then stained with FITC-co[r] ... See full document
7
Stoichiometry of Envelope Glycoprotein Trimers in the Entry of Human Immunodeficiency Virus Type 1
... The virus stocks, which are capable of a single round of infection, were harvested 2 days later, aliquoted, and stored at ⫺ ...mutant envelope glycoproteins were ...produce virus stocks with ... See full document
16
Related subjects