[PDF] Top 20 Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development
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Spatial pattern of sonic hedgehog signaling through Gli genes during cerebellum development
... axis during foliation of the ...restricted pattern in the anterior region of the medial cerebellum and in the region where the most posterior fissure begins to form ...EGL during early lobe ... See full document
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Understanding the role of the Sonic Hedgehog signaling pathway in cerebellar development and medulloblastoma genesis
... Medulloblastoma, an embryonal tumor of the cerebellum, is the most common pediatric brain malignancy. For decades, it has been known that a small subset of medulloblastomas present with myogenic differentiation. ... See full document
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Sonic hedgehog regulates Gli activator and repressor functions with spatial and temporal precision in the mid/hindbrain region
... Shh signaling to mes/r1 ...Shh signaling is distinct for ventral verses dorsal forebrain patterning (Fuccillo et ...two signaling functions in the ...Shh signaling regulates mes/r1 ... See full document
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Restriction of sonic hedgehog signalling during early tooth development
... downstream genes of removing the oral epithelium, the endogenous source of ...diffuse pattern within odontogenic epithelium and mesenchyme ...these genes changed ... See full document
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Genomic characterization of Gli activator targets in sonic hedgehog mediated neural patterning
... between Gli factors and Shh signaling in specification and the interactions among specific transcriptional regulators downstream of Shh input, lead to the model depicted in ...Shh signaling within ... See full document
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Sonic hedgehog in vertebrate neural tube development
... Shh signaling depends on a cell’s primary ...the signaling pathway in its ‘off-state’ as well as for transducing the ac- tive signal (reviewed in Goetz and Anderson, ...Shh signaling components ... See full document
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Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development
... downstream genes (Smad2, Ier3ip1 and Hdhd2) are ...adjacent genes (Smad2, Ier3ip1 and Hdhd2) determined using real-time RT-PCR in the P0 cerebellum of control (ctr) and Skor2 mutant (ko) ... See full document
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The level of sonic hedgehog signaling regulates the complexity of cerebellar foliation
... Shh signaling is required for cerebellar foliation Our finding that removing both Gli1 and Gli2 activators did not inhibit formation of the cardinal lobes raised the issue of whether Shh is required at all for the ... See full document
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The Sonic hedgehog pathway independently controls the patterning, proliferation and survival of neuroepithelial cells by regulating Gli activity
... the pattern of ...Wnt signaling in promoting the proliferation and survival of neural progenitors at least in dorsal regions of the caudal neural tube (Dickinson et ...The development of a number of ... See full document
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FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues
... HH signaling (Therond et ...for GLI transcription factors has also been ...limb development are much more dramatic than its effects on neural patterning, whereas the opposite is true for the Gli2 ... See full document
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... The Hedgehog (Hh) signaling pathway was first identified in the common fruit ...Hh signaling pathway plays an important role in the embryonic ...effects through a signaling cascade that ... See full document
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Acute myeloid leukemia – strategies and challenges for targeting oncogenic Hedgehog/GLI signaling
... Further evidence for an involvement of HH/GLI sig- naling in drug resistance was provided by Zahreddine et al. who analyzed primary tumor samples of patients that relapsed after monotherapy with ribavirin (an in- ... See full document
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Attenuation of hedgehog/GLI signaling by NT1721 extends survival in pancreatic cancer
... targeting hedgehog inhibitors (erismodegib, vismode- gib), had no effect on HH ligand-independent cell lines such as Panc1 at low micromolar concentrations (< 10 μM) ([17, 51], ...targets GLI downstream ... See full document
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Molecular analysis of coordinated bladder and urogenital organ formation by Hedgehog signaling
... We would like to specially thank Drs Alex Joyner and Chi-Chung Hui for their invaluable support. We would also like to thank Drs Denis Duboule, Shigeaki Kato, Larry Baskin, Jerry Cunha, Tsutomu Ogata, Chisa Shukunami, ... See full document
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Activation of the basal cell carcinoma pathway in a patient with CNS HGNET-BCOR diagnosis: consequences for personalized targeted therapy
... the Sonic Hedgehog (SHH) and of the WNT signaling pathway in two different regions of the primary tumor and of one inoculation metastasis compared to normal ...the GLI-inhibitor arsenic ... See full document
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Glucocorticoids and neonatal brain injury: the hedgehog connection
... The clinical syndrome of acetaminophen-induced liver injury represents the combined result of drug toxicity and a potent innate immune response that follows drug-induced cell death. In this issue of the JCI, Imaeda and ... See full document
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Regulation of DNA Damage Following Termination of Hedgehog (HH) Survival Signaling at the level of the GLI Genes in Human Colon Cancer
... of GLI using the classic SMO inhibitor cyclopamine [27, 33] (employed extensively in preclinical studies), or the clinically used agent GDC-0449, induces minimal cytotoxicity against cell line models of human ... See full document
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Original Article Activation of sonic hedgehog signaling attenuates oxidized low-density lipoprotein-stimulated brain microvascular endothelial cells dysfunction in vitro
... dysfunction through various signal path- ways, such as activation of NF-κB [21], GSK3β/ β-catenin [22], mitochondrial-dependent apop- totic pathway [9] and sodium-dependent glu- cose transporter (SGLT1) ... See full document
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Temporal perturbations in sonic hedgehog signaling elicit the spectrum of holoprosencephaly phenotypes
... Shh is expressed sequentially in the brain and in the face. The first site of Shh expression in the rostral head is the midline of the neural plate (29). Following neurulation, which occurs around stage 4 (St. 4) in an ... See full document
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Hedgehog/GLI signaling in tumor immunity - new therapeutic opportunities and clinical implications
... The patients´ response to immune checkpoint inhibi- tors correlates with the tumor mutational burden [92]. Given the extraordinary high mutation rate of BCC [62], chances are high that rational combination treatments ... See full document
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