[PDF] Top 20 Stem cell–ness: a “magic marker” for cancer

... data sets of adequate size. However, main- taining consistency of the thresholds and cutoffs used across data sets is fundamen- tal to this paradigm. If a certain threshold is used to indicate a specific change on the ... See full document

... Breast cancer is the most commonly diagnos- ed cancer and the leading cause of cancer related death in women worldwide ...Breast cancer poses a severe threat to women’s health, both in ... See full document

... squamous cancer cells ...colorectal cancer cell invasion via extracellular signal-regulated kinase (ERK)/ activating protein-1 (AP-1) activation ...colon cancer model [19, 20, ...colon ... See full document

... PD is a neurodegenerative disease that is characterized by motor dysfunctions such as tremor, slowness, stiff- ness, and balance problems. These symptoms are as- sociated with a progressive loss of dopaminergic ... See full document

... between cancer stem cells, tumourigenicity and surface marker expression, we studied the cell surface marker CD133 in primary melanoma cell ...a stem cell and ... See full document

... distributed cell-surface transmem- brane protein that belongs to the adhesion molecule super- ...with cell motility, tumorigenesis, invasion, and metastasis, and it has received universal attention in the ... See full document

... ovarian cancer patients [17, 28], On the contrary, other groups concluded that CD44 expression had no influence on the survival of patients with ovarian cancer [15, ... See full document

... mediates cell adhe- sion and migration by binding extracellular matrix compo- nents such as hyaluronic acid, osteopontin, or activating receptor tyrosine kinases, which are related with tumor progression and ... See full document

... This is the most diverse region of the CD44 molecule in which introduction of new exons modulates HA-binding affinity by inducing conformational changes or allowing CD44 isoforms to function as a co-receptor by ... See full document

... breast cancer receiving adjuvant chemotherapy, endo- crine therapy for 5 years plus additional chemotherapy for high-risk groups, such as patients with high tumor burden, advanced histological grade, and/or strong ... See full document

... stimulates cancer cell invasion and metastasis ...study cancer metastasis to establish the molecular mechanisms of EMT, for the develop- ment of novel therapeutic strategies ...regulates ... See full document

... uncontrolled cell proliferation and the formation of ...activate cell cycle checkpoints that curtail hyperproliferation, there are instances in which cells escape these checkpoints and develop into ...have ... See full document

... migrating cancer stem cells are very limited, mainly due to the lack of specific migrating markers to isolate migrating cancer stem cells from primary cancer stem ...primary ... See full document

... as cancer cells by developing a PS targeted specifically to the CSC of interest by creating an effective molecular ...call cell-SELEX (Sys- tematic Evolution of Ligands by Exponential Enrichment), whereby ... See full document

... Several electronic databases, including PubMed, Embase, and China Biology Medicine (CBM), were independently searched by two researchers (W Zhao and C Zang) through October, 2017. We used the MeSH/Emtree terms, combining ... See full document

... of stem cell (SC) marker-positive cancer cells in the submucosal invading ...SC marker-expressing cells among submucosal cancer cells in the gastric cancers (GCs) with focal ... See full document

... a marker of tumor stem cells, was overexpressed in HCC tissues in which expression of musashi1 was upregulated, and there was a dramatic correlation between expression of CD44 and ...liver cancer ... See full document

... Aim: Cancer stem cell surface markers are potent candidates for various ...three cancer stem cell markers ...bladder cancer (BC) in North ...CSC marker gene ... See full document

... as cell invasion and it is often upregulated during cancer ...breast cancer cells to identify novel regulators of vimentin ...breast cancer and high expression associated with poor clinical ... See full document

... of cancer stem cells has gained considerable interest in the last few decades, partly because of their potential implication in therapy ...global marker of adult stem ...as cancer ... See full document