[PDF] Top 20 Structural and Functional Characterization of the Mumps Virus Phosphoprotein

... The antiparallel orientation of the MuV P subunits places two N-terminal regions and two C-terminal regions on each end of the tetramer. This organization may be functionally required because both the N-terminal and the ... See full document

... and Functional Characterization of Pseudomonas aeruginosa CupB Chaperones Xun Cai 1 , Rui Wang 2 , Alain Filloux 3 *, Gabriel Waksman 2 , Guoyu Meng 1 * 1 State Key Laboratory of Medical Genomics, Shanghai ... See full document

... The tat proteins that contained alterations within the cluster of positively charged amino acid residues retained their ability to transactivate gene expression, albeit at markedly reduc[r] ... See full document

... That the 22S-28S RNA species are associated with polyribosomes and are not in cosedimenting ribonucleoprotein structures is shown by the fact that upon EDTA disruption of the polyribosom[r] ... See full document

... Lentivirus genomic organization: the complete nucleotide sequence of the env gene region of equine infectious anemia virus. Nucleotide sequence and transcriptional analy- sis of molecula[r] ... See full document

... These RNPs are responsible for virus transcription and replication in the infected cell nucleus. Here we have expressed, purified, and analyzed, structurally and functionally, for the first time, polymerase-RNA ... See full document

... world. Functional studies of two mimivirus tRNA synthetases confirmed the MetRS specificity for methionine and the TyrRS specificity for tyrosine and conformity with the identity rules for tRNA Tyr for ... See full document

... In our study, we aimed to characterize the interaction between host DEAD-box RNA helicase DDX5 and NS5B, an RNA-dependent RNA polymerase of HCV, using molecular biology techniques and structural analysis. Firstly, ... See full document

... Since the completed 36S RNA is found by RNase-gold as well as by in situ hybridization within the rosette of virus- induced vesicles but outside the replication complex per se, it is pos[r] ... See full document

... detailed characterization of the activity of enzymes involved in nutrient digestion and their mRNA expression levels reveals that protein, carbohydrate, and lipid digestion is associated to specific regions of ... See full document

... Neither of these EF hands binds calcium. Previous research has identified a disulfide bond between cysteines 94 and 100 in the holo- state. Until now it was unknown whether this also existed in the apo- form. Our data ... See full document

... our structural and functional studies indicate that the coronavirus spike protein can be classified as a class I viral fusion ...I virus fusion proteins known so far is the cleavage of the precursor ... See full document

... of structural changes rather than the dele- tion of putative binding ...the virus most closely related to mumps virus, were utilized to stabilize MuV P-domain ... See full document

... cleoprotein (vRNP), with viral polymerases composed of the P and L proteins (12). The F and HN proteins are envelope glyco- proteins, and the M protein is an intravirion protein that associ- ates with the cytoplasmic ... See full document

... disease virus infection is diagnosed by the presence of serum antibodies reactive with the major viral proteins, p40 and ...predicted structural model for the monomeric and the disulfide-linked dimeric ... See full document

... key structural and sequence motifs within A14, including sites of posttranslational modification, such as glycosylation, phosphorylation, and ...a virus expressing an allele of A14 that cannot form ... See full document

... Measles Virus Hemagglutinin Protein Maino Tahara, a Yuri Ito, b Melinda ...Measles, Mumps, Rubella and Herpesviruses Laboratory Branch, Division of Viral Diseases, Centers for Disease Control and ... See full document

... a functional point of view, they in- teract with many partners, including the L polymerase, N-RNA, and N 0 , the main nucleocapsid (RNA-N) and N 0 binding domains being located at the C and N termini of P, ... See full document

... Received 11 March 2009/Accepted 7 August 2009 The nucleocapsid protein (NP) of mumps virus (MuV), a paramyxovirus, was coexpressed with the phos- phoprotein (P) in Escherichia coli. The NP and P proteins ... See full document

... is possible that increasing the amount of NP could decrease activity through affecting the phosphorylation status of P, which may explain the decrease in activity when an excess of NP is transfected. The discovery that ... See full document