[PDF] Top 20 Structural Insight into a Human Neutralizing Antibody against Influenza Virus H7N9
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Structural Insight into a Human Neutralizing Antibody against Influenza Virus H7N9
... A H7N9 have been ...a human monoclonal antibody, HNIgGA6, that neutralized the H7N9 virus both in vitro and in ...to human cellular receptor binding, are also essential for ... See full document
12
H7N9 influenza virus neutralizing antibodies that possess few somatic mutations
... the human immune ...major structural features that account for the markedly low immunogenicity of these HA antigens in ...potent neutralizing activity against H7 influ- enza ...of ... See full document
14
An H7N1 Influenza Virus Vaccine Induces Broadly Reactive Antibody Responses against H7N9 in Humans
... Emerging H7N9 influenza virus infections in Asia have once more spurred the development of effective prepandemic H7 vac- ...avian influenza viruses—including H7—are poorly immunogenic, as ... See full document
11
Establish and Apply a Safe and Convenient Pseudovirus-Based Assay to Detect Neutralizing Antibodies against Influenza A (H7N9) Virus
... 8 human serum and 8 mouse serum samples. Neutralizing antibodies of these samples were also detected by microneutralization assay using live ...of neutralizing antibody titers, these two ... See full document
14
A Broadly Neutralizing Human Monoclonal Antibody Directed against a Novel Conserved Epitope on the Influenza Virus H3 Hemagglutinin Globular Head
... activity against different subtypes of influenza subtypes, such as H1; however, none of the previously described MAbs showed broadly neutralizing activity against diverse H3 ...a human ... See full document
8
Mutations in Influenza A Virus Neuraminidase and Hemagglutinin Confer Resistance against a Broadly Neutralizing Hemagglutinin Stem Antibody
... F10 antibody is an sBnAb derived from the IGHV1-69 germ line by panning phage display libraries generated from healthy donors with immobilized HA; F10 is broadly active against all group 1 viruses and ... See full document
16
Mutations in influenza A virus neuraminidase and hemagglutinin confer resistance against a broadly neutralizing hemagglutinin stem antibody
... and Structural Biology Commons, Bioinformatics Commons, Computational Biology Commons, Immunity Commons, Immunology of Infectious Disease Commons, Immunoprophylaxis and Therapy Commons, Influenza Humans ... See full document
41
Identification and Structural Characterization of a Broadly Neutralizing Antibody Targeting a Novel Conserved Epitope on the Influenza Virus H5N1 Hemagglutinin
... avian influenza A virus/H5N1 continues to be a serious threat to public health ...the virus in ...broadly neutralizing monoclonal antibody (MAb), HA-7, that potently neutralized all ... See full document
11
Neutralizing human monoclonal antibody against H5N1 influenza HA selected from a Fab phage display library
... of neutralizing antibodies with specificity away from the traditional mutation prone antigenic regions, against the conserved regions of hemagglutinin from H5N1 influenza virus has the ... See full document
10
Recognition of influenza H3N2 variant virus by human neutralizing antibodies
... analysis. Antibody heavy and light chain genes for each of the neutralizing mAbs were cloned from the hybridoma lines after single-cell flow cytometric sort- ing to biologically clone the cell ...of ... See full document
14
Isolation of Neutralizing Human Single Chain Antibodies Against Conserved Hemagglutinin Epitopes of Influenza a Virus H3N2 Strain
... Anti-influenza virus HA monoclonal antibodies, which showed protection when administered during the late phase of infection, conducted for antibody uses in the treatment and prophylaxis ... See full document
9
A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA
... the human population in 1968, they have caused higher morbidity and mortality rates during their dominant seasons than H1N1 or influenza B viruses, and therefore present a substantial health challenge 1–3 ...of ... See full document
15
Structural Basis for the Broad, Antibody-Mediated Neutralization of H5N1 Influenza Virus
... lost neutralizing activity against H5N6 and H5N8 viruses, which bear an ...the virus to escape 13D4 ...of antibody immunity of H5N6, which was considered to have been built up through ... See full document
19
Functional and Structural Characterization of Human V3-Specific Monoclonal Antibody 2424 with Neutralizing Activity against HIV-1 JRFL
... the virus Env due to the relative distance of its epitope from the sur- rounding ...the neutralizing activity of MAb 2424 was further enhanced after CD4 binding and also affected by the removal of N-glycan ... See full document
13
Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes
... by H7N9(Anhui). We next determined whether this low level of neutralizing activity in mouse convalescent-phase serum observed in the FFMN assay could provide in vivo protec- tion when passively transferred ... See full document
9
The Comparison of Sensitivity and Specificity of ELISA-based Microneutralization Test with Hemagglutination Inhibition Test to Evaluate Neutralizing Antibody against Influenza Virus (H1N1)
... detecting human antibodies to H5N1 virus in infected persons ...fluenza virus replication levels also are affected by the sublineages of MDCK ...of virus replication so that less than 25 ... See full document
7
Structure of a Classical Broadly Neutralizing Stem Antibody in Complex with a Pandemic H2 Influenza Virus Hemagglutinin
... characterized human antibodies against the HA stem, despite being isolated from a mouse nearly 2 decades ...antibodies against influenza virus that has renewed hope for a universal or ... See full document
6
Neutralizing Antibody Responses against Autologous and Heterologous Viruses in Acute versus Chronic Human Immunodeficiency Virus (HIV) Infection: Evidence for a Constraint on the Ability of HIV To Completely Evade Neutralizing Antibody Responses
... Neutralizing antibody assay. The antibody neutralization assay is a modifica- tion of the Monogram Biosciences HIV coreceptor tropism assay ...from virus stocks or ...cultures. Virus ... See full document
10
The interaction of influenza virus with neutralizing antibody
... in virus elimination by Tc may not be cytotoxicity itself but the secretion of gamma ...the virus titres in the lungs of mice by adoptive transfer of cloned Tc correlated with the production of gamma ...in ... See full document
387
Population seroprevalence of antibody to influenza A(H7N9) virus, Guangzhou, China
... of H7N9 cases in Guangzhou and second sample collection was initiated in October 2014, the population exposure to influenza A H7N9 may not be optimally cap- ...to H7N9 exposure might have been ... See full document
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