[PDF] Top 20 The study of dopamine dynamics in transgenic mouse models
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The study of dopamine dynamics in transgenic mouse models
... overexpression of UCP2 allows dopamine neurons to better resist MPTP toxicity (Conti et al., 2005; Chu et al., 2009). Overexpression of UCP2 decreased ROS formation in the substantia nigra, while the removal of ... See full document
184
CD40 deficiency mitigates Alzheimer's disease pathology in transgenic mouse models
... the transgenic animals with most amyloid ...genomic study that CD40 ligation of microglia specifically up-regulates APP metab- olism and tau phosphorylation related genes ... See full document
10
Pre-clinical imaging of transgenic mouse models of neuroblastoma using a dedicated 3-element solenoid coil on a clinical 3T platform.
... our study we demonstrated the feasibility of performing DCE-MRI simultaneously on three mice using the 3-channel/3-animal RF coil at 3T, enabling the successful pharmacokinetic analysis of Gd-contrast uptake ... See full document
10
Considerations for skin carcinogenesis experiments using inducible transgenic mouse models
... Due to the high frequency of RAS mutations in human epithelial cancers, investigations into the role of onco- genes in tumourigenesis commonly induce endogenous ras mutations in mice [6]. Endogenous oncogenic ras is ... See full document
7
Transgenic animal models for study of the pathogenesis of Huntington’s disease and therapy
... of transgenic animal models of HD have been established and provided an important insight into the pathogenesis of ...Various transgenic mouse models of HD are widely used for ... See full document
10
Original Article Cortical Neurons Transgenic for Human A 40 or A42 Have Similar Vulnerability to Apoptosis despite Their Different Amyloidogenic Properties
... recent study employing transgenic mouse models that expressed either Αβ40 or Αβ42 in the absence of human amyloid beta protein precursor (APP) ...of transgenic mice for Aβ might show ... See full document
14
Embryonic stem cells and transgenic mice in the study of hematopoiesis
... early mouse embryo the first blood cells, embryonic (or primitive) erythrocytes, are formed in the yolk sac blood islands starting at ...the dynamics of hematopoiesis are well ... See full document
8
Index Catalog // Carolina Digital Repository
... of dopamine in the dorsal striatum of the R6/2 transgenic mouse model of Huntington’s disease (Johnson et ...R6/2 transgenic mouse model is one of the models which has been used ... See full document
185
HLA transgenic mice as humanized mouse models of disease and immunity
... for mouse CD4 interaction with human class II raised serious concerns for using HLA class II transgenic mice as models to study human ...triple transgenic mice expressing DRA, DRB, and ... See full document
7
Is dopamine transporter-mediated dopaminergic signaling in the retina a noninvasive biomarker for attention-deficit/ hyperactivity disorder? A study in a novel dopamine transporter variant Val559 transgenic mouse model
... Here, we provide evidence that the altered DA signal- ing induced by a human DAT mutation associated with ADHD can be detected in a mouse model using the non-invasive ERG. Apart from this specific rare DAT Val559 ... See full document
12
No apparent transmission of transgenic α–synuclein into nigrostriatal dopaminergic neurons in multiple mouse models
... to study development and progression of PD pathology [9, ...a study where inoculation with homogenate from either A53T human α–syn transgenic mouse brains or mul- tiple system atrophy patient ... See full document
9
Modeling Mammary Cancer in Mice Conference, Jackson Laboratory, Bar Harbor, Maine, 5 8 October, 1999
... preclinical mouse models for breast ...to study the development of the mouse mammary ...of transgenic and knockout mouse models, provide a powerful approach to dissect the ... See full document
5
Gait dynamics in mouse models of Parkinson's disease and Huntington's disease
... striatal dopamine; previous reports indicate, however, that 30 mg/kg/day MPTP for 3 days reduce striatal dopamine by >50% ...gait dynamics in different chemically-induced models and genetic ... See full document
13
A previously functional tetracycline regulated transactivator fails to target gene expression to the bone
... specific mouse models for HGPS [9, 10, 11 and manu- scripts in ...bone-specific mouse model is due to problems with a1p-rtTA transgenic mice rather than with our human lamin A ...this ... See full document
6
Microarray analysis of gene expression in the liver of transgenic mouse model of HCV infection
... Previous study performed proteomic analysis of cancerous and noncancerous tissues from HCC patients with HCV infection determined that tro- pomyosin β chain proteins were decreased ...HCV transgenic mice, ... See full document
9
Computational models for the dynamics of early mouse embryogenesis
... The question of how cells are directed to the appropriate fate was later addressed by Holmes et al., (2017) who considered the same ODE description of the core GRN for TE/ICM specification. However, instead of ... See full document
13
Autophagy and neurodegeneration
... In addition to the drugs that directly inhibit mTOR, other drugs act indirectly through the mTOR pathway. For example, stimulation of the AMPK pathway can upregulate autophagy in an mTOR-dependent manner (111). One ... See full document
11
<p>Analgesic effects of amiodarone in mouse models of pain</p>
... Pharmaceutical, Tokyo, Japan) were dissolved or suspended in normal saline. BAYK8644 (Abcam, Cambridge, England) was dissolved in dimethyl sulfox- ide and diluted with normal saline (the fi nal concentration of dimethyl ... See full document
8
Mathematical Models of Helicopter Flight Dynamics
... flight dynamics mathematical model o f a helicopter that would be strictly determined would comprise a system o f non-linear, non-stationary, partial differential ... See full document
13
Insights into Parkinson’s disease from computational models of the basal ganglia
... kinetic models also allow us a better understanding of L-DOPA’s therapeutic actions and ...Network models of the striatum simulate L-DOPA as a global increase in dopamine [19, 21, ...Such ... See full document
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