[PDF] Top 20 A Study on Molecular Detection of Mutations Associated with Second Line Anti-tuberculosis Drug Resistance
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A Study on Molecular Detection of Mutations Associated with Second Line Anti-tuberculosis Drug Resistance
... first line anti-TB drugs, have emerged worldwide and seriously threaten TB control and prevention ...first- line antibiotics must be replaced with second-line drugs that are more costly ... See full document
7
Detection of second line drug resistance in Mycobacterium tuberculosis using oligonucleotide microarrays
... the resistance to FQs and second-line injectable drugs (KAN and CAP) in ...rifampin/isoniazid resistance [16], which has been used in Russia for more than 5 ...analyses mutations in the ... See full document
8
GenoType MTBDRsl for Molecular Detection of Second Line Drug and Ethambutol Resistance in Mycobacterium tuberculosis Strains and Clinical Samples
... the molecular tests is that they are unable to target all possible muta- tions involved in resistance, and as a consequence, some resistant strains will not be ...frequent mutations related to ... See full document
7
Increased Tuberculosis Patient Mortality Associated with Mycobacterium tuberculosis Mutations Conferring Resistance to Second Line Antituberculous Drugs
... genetic resistance profile of the DR-TB specimens evaluated, meaning that we might have failed to identify uncommon markers of resistance, such as rare katG mutations (23) or tlyA or gidB ... See full document
10
Second-line anti-tuberculosis drug resistance testing in Ghana identifies the first extensively drug-resistant tuberculosis case
... the mutations associated with resistance to fluoro- quinolones and aminoglycosides, 26 isolates were ...the line probe assay, GenoType MTBDRsl version ...the second- line ... See full document
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Detection of First and Second Line Drug Resistance in Mycobacterium tuberculosis Clinical Isolates by Pyrosequencing
... entire resistance-associated locus could be covered in only one or two sequencing ...where mutations are confined to a short stretch of the ...to line-probe assays is the discriminatory power ... See full document
8
Evaluation of the MTBDRsl Test for Detection of Second Line Drug Resistance in Mycobacterium tuberculosis
... lates from Germany and Brossier et al. from France (3a) at 69.2% and 57.0%, respectively. Similarly for kanamycin resis- tance, the sensitivity was 100% in this study and 86.7% and 77% in the other studies (6). ... See full document
6
The potential of a multiplex high throughput molecular assay for early detection of first and second line tuberculosis drug resistance mutations to improve infection control and reduce costs: a decision analytical modeling study
... f: Time counts from TB diagnosis and Rifampicin result comes at the same time as the TB diagnostic result Abbreviations; PE point estimate, PTB pulmonary tuberculosis, MDR multi-drug res[r] ... See full document
13
Evaluation of the GenoType MTBDRsl Version 2 0 Assay for Second Line Drug Resistance Detection of Mycobacterium tuberculosis Isolates in South Africa
... rapid molecular diagnostic tests in South Africa, notably the Xpert MTB/RIF assay (Cepheid, USA) and line probe assays (LPAs), for the detection of drug-resistant TB has markedly improved ... See full document
10
The diagnostic accuracy of the GenoType®MTBDRslassay for the detection of resistance to second-line anti-tuberculosis drugs (Review)
... the drug concentration used in culture-based DST (studies that used WHO-recommended concentrations versus those that did not) or population (patients suspected of having MDR-TB or XDR-TB), there were unfortunately ... See full document
123
GenoType® MTBDRsl assay for resistance to second-line anti-tuberculosis drugs
... culture-based drug susceptibility testing (DST) and genetic sequencing of the same ...define resistance (answered as ’yes’ if study consistently used recommended critical concentrations), those ... See full document
178
<p>Distribution and Frequency of <em>rpo</em>B Mutations Detected by Xpert MTB/RIF Assay Among Beijing and Non-Beijing Rifampicin Resistant <em>Mycobacterium tuberculosis</em> Isolates in Bangladesh</p>
... Current molecular diagnostic technologies recom- mended by WHO including Xpert MTB/RIF (Xpert) assay and the Line Probe Assay (LPA) can simultaneously detect Mycobacterium tuberculosis complex (MTBC) ... See full document
9
Comparative Study on Genotypic and Phenotypic Second Line Drug Resistance Testing of Mycobacterium tuberculosis Complex Isolates
... The molecular assay proved highly reliable in detecting ami- kacin, capreomycin, and moxifloxacin ...previous study, this mutation induces capreo- mycin resistance ...their study of the ... See full document
5
Rapid identification of extensively and extremely drug resistant tuberculosis from multidrug resistant strains; using PCR-RFLP and PCR-SSCP.
... AMK resistance and the remaining isolates were ...KAN resistance (9, ...for resistance mutations, but it occurs at a lower frequency ...no mutations in the rrs (9, ...the ... See full document
6
Molecular characterization of mutations associated with resistance to second line tuberculosis drug among multidrug resistant tuberculosis patients from high prevalence tuberculosis city in Morocco
... between mutations affecting the function and/or expression of chromosome- encoded targets and resistance to anti-tuberculosis drugs, molecular based methods have emerged as alternative ... See full document
8
Frequency and patterns of second-line resistance conferring mutations among MDR-TB isolates resistant to a second-line drug from eSwatini, Somalia and Uganda (2014–2016)
... with mutations in a short discrete region of the gyrA gene and less frequently gyrB, commonly re- ferred to as the quinolone-resistance determining region (QRDR) ...M. tuberculosis is attributed to ... See full document
9
Population Based Molecular Epidemiological Study of Tuberculosis in Malatya, Turkey
... describes drug resistance patterns and genotyping data on a total of 145 Mycobacterium tuberculosis strains isolated between 2000 and 2004 in Malatya, ...Turkey. Drug susceptibility results ... See full document
9
The GenoType® MTBDRsltest for resistance to second-line anti-tuberculosis drugs (Protocol)
... of drug-resistant TB (DR-TB) threatens to destabilise global TB ...were drug resistant (WHO 2009; WHO ...TB drug bud- ...adverse drug reactions (Dheda 2010a; Dheda ...sively drug ... See full document
17
Genotypic Detection of rpoB and katG Gene Mutations Associated with Rifampicin and Isoniazid Resistance in Mycobacterium Tuberculosis Isolates: A Local Scenario (Kelantan)
... and drug susceptibility testing of TB is time ...of molecular based methods, based on the detection of mutations in specific genes associated with resistance, is more efficient ... See full document
5
Evaluation of the GenoType MTBDR<em>plus</em> and MTBDR<em>sl</em> for the detection of drug-resistant <em>Mycobacterium tuberculosis</em> on isolates from Beijing, China
... each drug resistance-related gene implied that the sample was resistant to the specific ...detectable mutations within the region examined, the sample was considered susceptible to the respective ... See full document
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