[PDF] Top 20 Subchondral bone abnormalities in knee osteoarthritis
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Subchondral bone abnormalities in knee osteoarthritis
... and knee pain is still ...and knee pain among symptomatic OA patients (n=368) only when OPs were located in the patellofemoral compartment or when more than four OPs (any grade) were present anywhere in the ... See full document
194
Genome wide expression profiles of subchondral bone in osteoarthritis
... and subchondral bone structural parameters were deter- mined by micro-computed tomography; regions imme- diately adjacent were harvested for RNA isolation and microarray ...from subchondral ... See full document
12
Next-generation sequencing identifies articular cartilage and subchondral bone miRNAs after ESWT on early osteoarthritis knee
... and bone related musculoskeletal disorders for over 20 ...long bone fractures [12, ...the knee [19, 20], and induces regression or retardation of established OA changes of the knee in rats ... See full document
10
The association between subchondral bone cysts and tibial cartilage volume and risk of joint replacement in people with knee osteoarthritis: a longitudinal study
... Subchondral bone cysts were initially thought to result from degenerative changes to cartilage, creating a com- munication between subchondral bone and the synovial space, allowing breach of ... See full document
7
Improved clinical outcome measures of knee pain and function with concurrent resolution of subchondral Bone Marrow Edema Lesion and joint effusion in an osteoarthritic patient following Pentosan Polysulphate Sodium treatment: a case report
... of osteoarthritis and arthroscopic partial medial meniscectomy presented with pain of the left knee and was on a waiting list for Total Knee Arthroplasty ...the knee, using a 3-Tesla proton ... See full document
5
Correlation between μCT imaging, histology and functional capacity of the osteoarthritic knee in the rat model of osteoarthritis
... the subchondral bone at the medial tibial plateau, the lengths of tibial plateau for the sham and MMT rats were measured to average ...dral bone and ...and subchondral bone to always be ... See full document
12
Characterization of multinucleated giant cells in synovium and subchondral bone in knee osteoarthritis and rheumatoid arthritis
... and cartilage. We did not identify cathepsin K activity in MGCs that were distant from bone or cartilage in human synovia, in contrast to previous suggestions that cathepsin K-positive staining might be a general ... See full document
10
Assessment of subchondral bone marrow lesions in knee osteoarthritis by MRI: a comparison of fluid sensitive and contrast enhanced sequences
... In line with the study by Roemer et al. [11], we found that the CEA-BML volume by T1 CE FS gener- ally was smaller than the BML volume by STIR using MS. We did, however, find CAS to be unreliable on T1 CE FS sequences in ... See full document
9
Development of a clinical prediction algorithm for knee osteoarthritis structural progression in a cohort study: value of adding measurement of subchondral bone density
... for knee OA structural progression is the medial-to-lateral tibial plateau bone mineral density ratio (M:L BMD ...the bone underlying the knee, and the meas- urement can be ...articular ... See full document
9
A protocol for a multicentre, randomised, double blind, placebo controlled trial to compare the effect of annual infusions of zoledronic acid to placebo on knee structural change and knee pain over 24 months in knee osteoarthritis patients – ZAP2
... Subchondral bone marrow lesions (BMLs), visible on magnetic resonance imaging (MRI) have been shown to be an important feature in ...the bone marrow, and are a promising target for ...with ... See full document
12
Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative
... the bone as ...into subchondral region in the index compart- ment, which would have been detected with our segmen- tation ...and bone marrow lesion (BML) volume ... See full document
11
Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain
... aberrant subchondral bone remodeling could be an important origin of OA ...the knee joint ...direct knee pinching or press using a pressure application measurement (PAM) device in a mouse DMM ... See full document
19
Investigation of Subchondral Bone Abnormalities associated with Osteoarthritis using Image-Based Biomechanics
... upon bone and can alter its composition and structure to accommodate different ...most bone surfaces and are responsible for the synthesis and deposition of the organic bone matrix or osteoid ... See full document
123
Knee osteoarthritis patients with more subchondral cysts have altered tibial subchondral bone mineral density
... trabecular subchondral bone [2] and the epiphyseal region tibia [19], we only considered cysts within the subchondral region at a depth of ...the subchondral surface ...adjacent bone, ... See full document
9
The role of subchondral bone in osteoarthritis
... MRI will continue to be an important research tool in OA. There has been a rapid improvement in imaging technology over the last 20 years and this has translated to improved understanding of the importance of individual ... See full document
194
Effect of Vitamin D supplementation on synovial tissue volume and subchondral bone marrow lesion volume in symptomatic knee osteoarthritis
... Two published trials have looked at MRI outcomes following vitamin D intervention in patients with symptomatic knee OA, though in only one of these, the Australian VIDEO study, did the authors look at synovitis ... See full document
7
Tibial subchondral bone size and knee cartilage defects: relevance to knee osteoarthritis
... Tibial subchondral bone area is associated with prevalence and severity of knee cartilage defects (15), and with increases in tibiofemoral carti lage defects over time (7) which, in turn, lead to ... See full document
23
Extracorporeal shockwave therapy shows a number of treatment related chondroprotective effect in osteoarthritis of the knee in rats
... The knee spe- cimens including the articular cartilage and the sub- chondral bone of proximal tibia and distal femur were ...The subchondral bone remodeling was evaluated with tissue ... See full document
8
Oestrogen is important for maintenance of cartilage and subchondral bone in a murine model of knee osteoarthritis
... cortical bone became thinner in the first 3 weeks in both areas (patella and tibia) after OVX+IA, but in the tibia the thickness continued to be decreased, while in the patella the thickness subsequently increased ... See full document
12
Quantitative evaluation of subchondral bone microarchitecture in knee osteoarthritis using 3T MRI
... Moreover, subchondral bone and cartilage form a unit in anatomic regions to sustain mechanical ...and subchondral bone interact and that chondrocytes and bone cells are intimately ... See full document
9
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