[PDF] Top 20 The systems biology of MHC class II antigen presentation
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The systems biology of MHC class II antigen presentation
... controlling MHC-II distribution, we silenced all candidates and the effect on MHC-II distribution was visualized by ...control MHC-II trafficking but will require further ... See full document
97
Virus-Like Particles as Carriers for T-Cell Epitopes: Limited Inhibition of T-Cell Priming by Carrier-Specific Antibodies
... core antigen (HBcAg) fused to lymphocytic chorio- meningitis virus (LCMV)-derived MHC class I-restricted pep- tide p33 (23) or MHC class II-restricted peptide p13 ...with ... See full document
8
Original Article Design of a ProDer f1 vaccine delivered by the MHC class II pathway of antigen presentation and analysis of the effectiveness for specific immunotherapy
... of Ii-Key to antigen or related epitope was capable of enhancing MHC class epitope charging and Th cell activation [18, ...The Ii-Key hybrids are composed of the Ii moiety linked ... See full document
9
Optimal MHC II restricted tumor antigen presentation to CD4+ T helper cells: the key issue for development of anti tumor vaccines
... CIITA-dependent MHC class II expression in tumor cells was instrumental to trigger a protective immune response against the parental tumor was also demonstrated by vaccination experi- ments with non ... See full document
7
Whole protein and defined CD8+ and CD4+ peptides linked to penetratin targets both MHC class I and II antigen presentation pathways
... corresponding MHC class I-binding peptides which were recognized by CTLs only in the presence of furin-sensitive linker sequences ...and MHC class I-binding peptides were generated in a TAP- ... See full document
32
Mutanome and expression of immune response genes in microsatellite stable colon cancer
... stage II CRC tumors. The exome of 42 stage II, microsatellite stable, colon tumors (21 of them relapse) and their paired mucosa were sequenced and ...the antigen presentation machinery were ... See full document
15
Footprints of antigen processing boost MHC class II natural ligand predictions
... processed MHC eluted ...current MHC class II binding prediction and/or in vitro binding assay methods, since researchers could use these tools to select which peptides to include in a T cell ... See full document
15
The involvement of heat shock protein molecular chaperones in MHC class II antigen processing and presentation
... of MHC class n molecules to phagosomes and phagolysosomes may be by fusion of phagosomes and endocytic compartments (Mayorga ...that antigen may be transported to endosomes as a means of encounter ... See full document
216
Kaposi's Sarcoma-Associated Herpesvirus-Encoded Viral IRF3 Modulates Major Histocompatibility Complex Class II (MHC-II) Antigen Presentation through MHC-II Transactivator-Dependent and -Independent Mechanisms: Implications for Oncogenesis
... complex class II (MHC-II) DR expression with slow kinetics but, more impor- tantly, can substantially inhibit recognition by KSHV-specific CD4 T cells prior to its effects on ... See full document
11
Evidence for Antibody-Mediated Enhancement of Simian Immunodeficiency Virus (SIV) Gag Antigen Processing and Cross Presentation in SIV-Infected Rhesus Macaques
... of class I was achieved on the surface of ...the MHC class I molecules. Second, blocking of MHC class II determinants also demonstrated modest but clearly identifiable ... See full document
15
Human Cytomegalovirus Protein US2 Interferes with the Expression of Human HFE, a Nonclassical Class I Major Histocompatibility Complex Molecule That Regulates Iron Homeostasis
... transport systems or immune responses (6, 8, 25, 26, 30, ...a class I MHC molecule, HFE complexes might be modulated by viral anti- gens and might thus manifest another target for virus manip- ... See full document
6
Autophagy in Innate Recognition of Pathogens and Adaptive Immunity
... immune systems to protect host cells from invading pathogens and regulate uncontrolled immune ...facilitate MHC class II presentation of intracel- lular antigens to activate CD4 T ...as ... See full document
7
Interaction of the proteins which regulate MHC class II-mediated antigen presentation by antigen presenting cells
... extra [35S]-methionine on the cells. Labelled intracellular methionine was chased for various periods, generally Oh, 3h, 6h and overnight, by incubating cells at 37°C in a 5% C02 atmosphere in the culture medium ... See full document
171
Approaches to Improve Chemically Defined Synthetic Peptide Vaccines
... in MHC class I or -II for presentation is characterized by distinct protease sys- ...While MHC class I processing pathways involves cytosolic proteasomes, peptidases and ... See full document
8
Presentation of intracellular antigen with MHC class II molecules
... investigated class II presentation of influenza haem agglutinin (HA) transport m utants in B ...ith class II in a chloroquine-sensitive m ...ith MHC class II, b u t ... See full document
235
Aspects of the cell biology of antigen processing for MHC II
... and MHC II pathways were studied in disrupted A20 ...for presentation (for example: Shimonkevitz et al, 1983; Eisenlohr et al, 1988; Shaw and Chain, 1989; Bikoff, 1992; Hunt et al, 1992b; Poirier, ... See full document
213
Mannosylated T/Tn with Freund’s adjuvant induces cellular immunity
... predict antigen presentation power, we monitored MHC class II (MHC II) lev- els (Figure 4(d)) 10 days after final immunization and 1 month after TA3HA tumor cell challenge ... See full document
15
Molecular analysis of T cell receptors: Mapping T cell recognition and repertoire in two human immune responses
... CD4+, class 11 restricted T cell clones from an individual w ho is sensitised to Dermatophagoides ...group II antigen in the context of DR52 (a class II m olecule w hich uses a p chain ... See full document
251
The Missing Link in Epstein-Barr Virus Immune Evasion: the BDLF3 Gene Induces Ubiquitination and Downregulation of Major Histocompatibility Complex Class I (MHC-I) and MHC-II
... surface MHC molecules through increased internalization and a delayed appearance ...of MHC class I and class II internalization and appearance at the cell surface of BDLF3-expressing ... See full document
12
Dendritic Cells and Macrophages Are Productively Infected by Poliovirus
... These antigen-presenting cells (APCs) acquire and process antigens, displaying them in the context of HLA class I and II molecules at the cell surface (9, 31, 43, ... See full document
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