[PDF] Top 20 Temperature-Sensitive Simian Virus 40 Mutant Defective in a Late Function
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Temperature-Sensitive Simian Virus 40 Mutant Defective in a Late Function
... To determine whether mutant SV40tsTNG-1 also induced cellular DNA synthesis, 5-day-old cultures of primary mouse kidney cells 3.3 X 106 cells per culture were infected at input multiplic[r] ... See full document
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Extended life span of human endometrial stromal cells transfected with cloned origin-defective, temperature-sensitive simian virus 40.
... The large T antigen of the DNA virus simian virus 40 SV40 increases the life span of human cells in culture, and transformation by SV40 has become a standard approach in producing cell l[r] ... See full document
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Studies of an Influenza A Virus Temperature-Sensitive Mutant Identify a Late Role for NP in the Formation of Infectious Virions
... A virus nucleoprotein (NP) is a single-stranded RNA-binding protein that encapsidates the virus genome and has essential functions in viral-RNA ...a temperature- sensitive (ts) NP ... See full document
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Isolation and characterization of a heat-inducible simian virus 40 mutant.
... 374 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest We have isolated a new type of temperature-sensitive mutant of simian virus 40 SV40 that is capable of productive in[r] ... See full document
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DNA infectivity and the induction of host DNA synthesis with temperature-sensitive mutants of simian virus 40.
... This, and the fact that mutants of the A group induce host DNA synthesis in CV-1 cells although they do not replicate viral DNA at 40 C 5, 18 suggested either that an early function othe[r] ... See full document
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Genetic Analysis of Influenza Virus NS1 Gene: a Temperature-Sensitive Mutant Shows Defective Formation of Virus Particles
... Another mutant contains an altered effector domain (50) and also shows a reduced replication in tissue-cultured ...either virus showed an increased interferon response com- pared to the results seen with ... See full document
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A simian virus 40 dl884/tsA58 double mutant is temperature sensitive for abortive transformation.
... Our major conclusions are that i although the mutant tsA58 is not temperature sensitive for the maintenance of transformation, the d18841tsA58 double mutant is; ii small t antigen can pr[r] ... See full document
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Ability of nonpermissive mouse cells to express a simian virus 40 late function(s).
... Moreover, we report that SV40 late mRNA's are produced by infected mouse cells either when infection is performed at a nonpermissive temperature with the nonleaky tsA58 mutant or when la[r] ... See full document
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Genetic Analysis of Simian Virus 40 III. Characterization of a Temperature-Sensitive Mutant Blocked at an Early Stage of Productive Infection in Monkey Cells
... The mutant virion can adsorb to and penetrate the cell normally at the restrictive temperature, but cannot induce the synthesis of cellular deoxyribonucleic acid DNA nor initiate the syn[r] ... See full document
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Biological and biochemical studies of cells transformed by simian virus 40 temperature-sensitive gene A mutants and A mutant revertants.
... Virus recovered from both of the tsA30-transformed cell lines was temperature sensitive for viral DNA synthesis in BSC-1 cells, as is characteristic of SV40 A mutants Table 2.. That reco[r] ... See full document
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Recombination Between Endogenous and Exogenous Simian Virus 40 Genes. I. Rescue of a Simian Virus 40 Temperature-Sensitive Mutant by Passage in Permissive Transformed Monkey Lines
... Rescue of a Simian Virus 40 Temperature-Sensitive Mutant by Passage in Permissive Transformed Monkey Lines Received for publication 11 May 1977 Passage of the simian virus 40 SV40 temper[r] ... See full document
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Simian virus 40 mutants carrying two temperature-sensitive mutations.
... Double mutants of A:B, A:C, and A:BC complementation groups, like their A parent, were defective in viral DNA replication, in the induction of host DNA synthesis, and in the transformati[r] ... See full document
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Products of complementation between temperature-sensitive mutants of simian virus 40.
... These results imply that i the D product may be synthesized late in infection; ii therefore, any defect exhibited by D virions early in infection probably results from the introduction o[r] ... See full document
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Temperature-Sensitive Mutants of Simian Virus 40: Infection of Permissive Cells
... Plaque characteristics of wild-type and mutant simian virus 40 SV40 stocks propagated at 32 C Virus Efficiency of plating39 C/32 C Time of plaque appearance in days d Infected cultures w[r] ... See full document
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Characterization of T antigen in cells infected with a temperature-sensitive mutant of simian virus 40.
... The present study demonstrates that a molecular form of T antigen induced by ts 900, a transformation-defective ts mutant of SV40 29, is more heat labile than that induced by WT virus, i[r] ... See full document
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Characterization of simian cells tranformed by temperature-sensitive mutants of simian virus 40.
... In addition, the role of the gene A product if any in the maintenance of the transformed 1106 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Seven lines derived from p[r] ... See full document
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Mutant of simian virus 40 large T-antigen that is defective for viral DNA synthesis, but competent for transformation of cultured rat cells.
... The failure to rescue virus either by cell fusion or by transfection of the cloned viral DNA insertion indicated that the SV40 genome integrated in SVRE9 cells was defective in some lyti[r] ... See full document
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Control of protein synthesis by a temperature-sensitive mutant of reovirus 3. I. Temperature-sensitive function of ts261-b mutant.
... The protein-synthesizing ability of the Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest 40 IKEGAMI of in vivo synthesis at 370C of the mutant virusspecific ss RNAs of t[r] ... See full document
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Function of simian virus 40 gene A in transforming infection.
... A A hamster embryo cell stably transformed by A58 at 33 C and then incubated in a dilute suspension of single cells for 2 weeks at 41 C without cell division; B formation of a transforme[r] ... See full document
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Simian virus 40 late transcripts lacking excisable intervening sequences are defective in both stability in the nucleus and transport to the cytoplasm.
... By quantitative analysis of the viral late RNAs accumulated in the nucleus and cytoplasm of monkey cells transfected with these cDNA mutants, we showed that i the SV40 late mRNAs accumul[r] ... See full document
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