[PDF] Top 20 The nuclear pore complex
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The nuclear pore complex
... purified nuclear envelopes or the separation of the subcomplexes formed during NPC breakdown at mitosis ...a nuclear reassembly assay in Xenopus egg extracts ...a complex with yeast ... See full document
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Differential Targeting of Nuclear Pore Complex Proteins in Poliovirus-Infected Cells
... two nuclear pore complex (NPC) proteins, Nup153 and ...125-MDa complex composed of multiple copies of 30 different ...of nuclear import and relocalization of host nuclear ... See full document
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Nucleoporin FG Domains Facilitate mRNP Remodeling at the Cytoplasmic Face of the Nuclear Pore Complex
... ABSTRACT Directional export of messenger RNA (mRNA) protein particles (mRNPs) through nuclear pore complexes (NPCs) requires multiple factors. In Saccharomyces cerevisiae, the NPC proteins Nup159 and Nup42 ... See full document
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Super-resolution imaging visualizes the eightfold symmetry of gp210 proteins around the nuclear pore complex and resolves the central channel with nanometer resolution
... most complex molecular machines of cells is the nuclear pore complex (NPC), which controls all trafficking of molecules in and out of the ...oocyte nuclear envelopes, with a lateral ... See full document
6
Single molecule imaging to characterise the transport mechanism of the Nuclear Pore Complex
... In the eukaryotic cell, a large macromolecular channel, known as the Nuclear Pore Complex (NPC), mediates all molecular transport between the nucleus and cytoplasm. In recent years, single-molecule ... See full document
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Mutations in multiple components of the nuclear pore complex cause nephrotic syndrome
... In summary, we here discovered recessive mutations in the genes NUP85, NUP133, and NUP160 as 3 monogenic causes of SRNS. Interestingly, all 3 genes and the gene NUP107, in which we found 3 pathogenic alleles, encode ... See full document
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Nuclear Pore Complex Function in Saccharomyces cerevisiae Is Influenced by Glycosylation of the Transmembrane Nucleoporin Pom152p
... the nuclear envelope occurs through nuclear pore complexes (NPCs), which are composed of ...the nuclear protein import defects associated with the deletion of ... See full document
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Elucidating the Mechanism of mRNA Export Regulation by the Nuclear Pore Complex
... the nuclear envelope, separating genetic information contained in the nucleus from the greater cell ...The nuclear pore complex (NPC) is nature’s largest protein channel, and it is the sole ... See full document
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Mengovirus-Induced Rearrangement of the Nuclear Pore Complex: Hijacking Cellular Phosphorylation Machinery
... the nuclear pores appears to be primarily due to proteolytic degradation of some nucleoporins (protein components of the pore), whereas this effect in cardiovirus-infected cells is triggered by the leader ... See full document
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Importin β modulates the permeability of the nuclear pore complex in a Ran dependent manner
... the nuclear face of the NPC, in addition to displacing impβ from cargos (Gorlich et ...the pore but had an ∼100-fold higher probability of exiting the pore at the cytoplasmic face than the ... See full document
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Selective Removal of FG Repeat Domains from the Nuclear Pore Complex by Enterovirus 2Apro
... The retention of Nup structural domains may also contribute to maintaining NPC function in infected cells. The results pre- sented above indicate that the C-terminal structural domain of Nup98 remains associated with the ... See full document
11
Interaction of the Human Immunodeficiency Virus Type 1 Vpr Protein with the Nuclear Pore Complex
... The accessory gene vpr is present in all viruses that belong to the five phylogenetic lineages of primate lentiviruses. The hu- man immunodeficiency virus type 1 (HIV-1) Vpr protein is well conserved in terms of primary ... See full document
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The Yeast Nuclear Pore Complex and Transport Through It
... and nuclear bas- kets have been seen to project from the yeast NPC (Figure 1) (Kiseleva et ...the nuclear basket seems to be made of Tpr (Cordes et ...the nuclear basket (Strambio-de-Castillia et ... See full document
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Ran GTPase Regulates Mad2 Localization to the Nuclear Pore Complex
... In all eukaryotes, mitosis is controlled through the abun- dance of B-type cyclins and Pds1p (also known as Securin) (13). B-type cyclins associate with and activate the cdc28 kinase in budding yeast during mitosis. ... See full document
7
Role of nuclear pore complex in simian virus 40 nuclear targeting.
... The nuclear accumulation of virion protein components and large T antigen in nonpermissive NIH 3T3 cells was similar to that in the permissive host, indicating that the ability to use NP[r] ... See full document
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Inhibition of Nuclear Import and Alteration of Nuclear Pore Complex Composition by Rhinovirus
... normally nuclear residents. The cytoplasmic accumu- lation of endogenous nuclear proteins was detectable by 4 to 5 h after infection and was complete by 6 to 7 h after infection (data not ... See full document
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Walther, Tobias (2002): The role of Peripheral Nuclear Pore Complex (NPC) structures in nuclear transport and NPC architecture. Dissertation, LMU München: Fakultät für Biologie
... trimeric complex with RanGTP (Arts et ...more complex pathway utilising an adaptor molecule, PHAX, which bridges the interaction of exportin-1 with CBC and the 5' cap structure of the ...hexameric ... See full document
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Differential Processing of Nuclear Pore Complex Proteins by Rhinovirus 2A Proteases from Different Species and Serotypes
... 218, 247, and 298. The Cw12 and Cw24 enzymes cleaved some of these sites (103 and 247[?]), but not others, and there were individual differences between these proteases in the rates and final profile patterns. Neither of ... See full document
10
Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells
... We next tested whether HIV-1 viruses with mutations on capsid residue N57 require Nup153 expression for infectivity. To this end, we transiently knocked down expression of Nup153 in HeLa cells and challenged the cells ... See full document
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Herpesvirus Capsid Association with the Nuclear Pore Complex and Viral DNA Release Involve the Nucleoporin CAN/Nup214 and the Capsid Protein pUL25
... itory effect on the number of incoming capsids associating with the nucleus, and a similar effect was observed when Nup358/ RanBP2 levels were reduced by RNA silencing. Nup358/ RanBP2 is a large nucleoporin that is a ... See full document
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