[PDF] Top 20 The plasminogen activator/plasmin system
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The plasminogen activator/plasmin system
... However, the concept of proteolytic activation of hormones and growth factors should be revisited in the light of recent studies: plasmin can activate the latent form of TGF,3 and releas[r] ... See full document
7
Extracellular proteolysis in the adult murine brain
... the plasminogen activator/plasmin system in the adult murine central nervous ...Tissue-type plasminogen activator is synthesized by neurons of most brain regions, while prominent ... See full document
8
Plasmin and plasminogen activator inhibitor type 1 promote cellular motility by regulating the interaction between the urokinase receptor and vitronectin
... and plasmin are rate-limiting in fibrin turnover, wound healing, and the ability of cells to move through ...in plasminogen-defi- cient mice (2), in mice overexpressing PAI-1 (47), and in sev- eral models ... See full document
11
Beta-amyloidolysis and glutathione in Alzheimer's disease
... (GSH) system, the proteolytic tissue plasminogen activator (t-PA)/plasminogen/ plasmin system, regulated by plasminogen activator inhibitor (PAI-1), and neuroserpin ... See full document
8
Extravascular fibrin, plasminogen activator, plasminogen activator inhibitors, and airway hyperresponsiveness
... AU/ml plasmin (Sigma-Aldrich) to the same buffer was added to achieve plasmin concentration of ...with plasmin, the concentration of D-dimer was deter- mined (postincubation ... See full document
9
Structural and kinetic comparison of recombinant human single and two chain tissue plasminogen activator
... Differences in steady state protein fluorescence were also noted with denaturation of these plasminogen activators, as well as in the quenching of intrinsic fluorescence of the reduced, alkylated species by ... See full document
8
alpha Fucose mediated binding and degradation of tissue type plasminogen activator by HepG2 cells
... Binding and degradation of tissue-type plasminogen activator by the human hepatoma cell line HepG2.. Interactions between tissue-type plasminogen activator and extracellular matrix assoc[r] ... See full document
9
Thrombin induction of plasminogen activator inhibitor in cultured human endothelial cells
... of plasminogen activator (PA) and plasminogen activator-inhibitor (PA-I) in medium conditioned by primary cultures of human umbilical vein endothelial ... See full document
6
Targeted expression of plasminogen activator inhibitor(PAI)-1 to the stomach inhibits gut-brain signalling by the satiety hormone cholecystokinin (CCK)
... liquifies its contents and controls the rate at which food enters the duodenum. There are different types of cell in the stomach that are responsible for different roles in digestion. Parietal cells are responsible for ... See full document
236
Role of t-PA and PAI-1 variants in temporal lobe epilepsy in Chinese Han population
... gen activator (t-PA) is responsible for the activation of plasminogen to plasmin, which then degrades extracellu- lar matrix (ECM) components, promoting synaptic plas- ticity and influencing neurite ... See full document
6
Central serous chorioretinopathy: a pathogenetic model
... tissue plasminogen activator, increasing plasminogen activator inhibitor 1 (PAI-1), and plasmin-α2- plasmin inhibitor ... See full document
5
Association of dietary soy with expression of various pro-inflammatory genes in porcine phagocytes
... urokinase plasminogen activator (u-PA), its receptor (u-PAR) and plasminogen activator inhibitors type 1 and 2 (PAI-1 and PAI-2) in blood monocytes and neutrophils from 72 day old pigs fed ... See full document
8
uPA/uPAR and SERPINE1 in head and neck cancer: role in tumor resistance, metastasis, prognosis and therapy
... the plasminogen activator system in head and neck squamous cell carcinoma (HNSCC), particularly of its uPA (urokinase plasminogen activator) / uPAR (urokinase plasminogen ... See full document
16
A study on factors influencing the Outcome of Thrombolysis in Acute Myocardial Infarction
... plasminogen activator inhibitor from endothelium enhancement of plasminogen activation by f-fibrin and plasmin inhibiton by alpha 2 antiplasmin ...for plasminogen and plasminogen ... See full document
83
Inhibition of angiogenesis by platelets in systemic sclerosis patients
... minogen activator, plasminogen activator inhibitor type 1, and platelet-derived growth factor in patients with Raynaud’s phenomenon associated with scleroderma than in control subjects, suggesting ... See full document
9
Behçet’s disease: new insight into the relationship between procoagulant state, endothelial activation/damage and disease activity
... It has been reported that abnormal fibrinolysis may contribute to thrombosis, atherosclerosis and vascular stenosis [35]. Fibrinolysis has been previously studied in BD with conflicting results, which was probably due to ... See full document
9
Plasmin releases the anti-tumor peptide from the NC1 domain of collagen XIX
... by plasmin in cell culture. Plasminogen/plasmin activation system in SKMEL28 melanoma cell ...(B) Plasmin activity was measured in the SKMEL28 culture medium using a plasmin ... See full document
13
Tissue plasminogen activator (tPA) inhibits plasmin degradation of fibrin A mechanism that slows tPA mediated fibrinolysis but does not require alpha 2 antiplasmin or leakage of intrinsic plasminogen
... extrinsic plasminogen and consequent leaching of clot-bound ...tissue plasminogen activator (tPA) to fibrin gels resulted in lysis rates that displayed a maximum, with significantly slower rates ... See full document
9
The neuroendocrine-like phenotype of gastric myofibroblasts and its significance in cancer.
... Two IGFBPs were identified in the current project: IGFBP-5 and IGFBP-7. The former was described about 20 years ago. In addition to its systemic IGF-related effects via the circulation, IGFBP-5 binds to IGF-IR on the ... See full document
224
Elevated circulating PAI-1 levels are related to lung function decline, systemic inflammation, and small airway obstruction in chronic obstructive pulmonary disease
... Background: Plasminogen activator inhibitor-1 (PAI-1) and soluble urokinase-type plasminogen activator receptor (suPAR) participate in inflammation and tissue remolding in vari[r] ... See full document
8
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