[PDF] Top 20 Transduction of Cellular Sequence by a Human Immunodeficiency Virus Type 1-Derived Vector

... via transduction of cellular counterparts termed proto- oncogenes (c-onc ...of transduction by retroviruses proposes that the parental pro- virus integrates next to the sequence that is ... See full document

... vaccine vector, especially against ...VEE vector expressing influenza virus hemagglutinin (HA) ...VEE-HA vector afforded complete protection against disease after a subsequent intranasal ... See full document

... the virus lipid bilayer while the C-terminal end of the molecule protrudes towards the inner regions of the virion ...retroviral vector particles as ... See full document

... to human immunodeficiency virus type 1 (HIV-1) diversity, with homol- ogous recombination being more frequent than nonhomologous ...of sequence divergence on the frequency ... See full document

... efficient transduction and heritable genomic integration in largely non- dividing, quiescent stem ...in vector design and by using VSV-G pseudotyping, hematopoi- etic stem cells can be readily transduced ex ... See full document

... The retroviral Gag protein is synthesized as a polyprotein which is cleaved by a virally encoded protease shortly after, or concomitant with, viral budding (12, 25). In HIV-1, cleavage results in four major mature ... See full document

... express human transgenes and thereby be rendered infectible by HIV-1 in a transgenic ani- ...of human reference cultures, and levels for rat macrophages were 16 to ...(empty vector) (A) ... See full document

... the vector genome is high enough in the producer system and if any transgene is expressed from a promoter other than the HIV-1 long terminal repeat ...the human cytomegalo- virus (HCMV) ... See full document

... the cerebrospinal fluid (CSF) in HIV-positive patients. The CNS offers a unique environment for HIV replication, because the presence of the blood-brain barrier (BBB) and the blood- CSF barrier restricts viral ... See full document

... index derived from a real data set to that derived from a simulated random data set and estimates a probability that a pair of observed amino acids covary to a greater extent than would be expected based on ... See full document

... cells), and the results shown represent the mean ⫾ the standard error of the mean for each datum point. Data denoted with an asterisk correspond to mean of only two values, with the corresponding stan- dard deviation; ... See full document

... FIG. 1. Alignment of Nef protein sequences derived from HIV-1-infected individuals with different rates of disease ...were derived from the present study (NPs 1 to 28, SPs 1 to ... See full document

... acid sequence conformed to the sequences for other HIV-1 subtype B Gag proteins in the HIV sequence database (Los Alamos National Laboratory; ...consensus sequence for the initiation of ... See full document

... of human immunodeficiency virus type 1 (HIV-1) enables it to continuously evade host CD8 ⴙ T-cell ...examined sequence polymorphisms arising across the HIV-1 genome ... See full document

... Table 1 also illustrates that the viral vector can be quantitatively concentrated 100-fold by ul- ...CCR5-pseudotyped vector did not mediate ...the vector is illustrated in Fig. 2C, where ... See full document

... pressing vector had a greater number of tetramer-specific CD8 ⫹ T cells than mice treated with the HIV vector alone or boosted with IL-2 over ...IL-15-expressing vector to naïve animals demonstrated ... See full document

... were responsible for its binding to the HIV-1 LTR. In partic- ular, we investigated whether either the glycine-rich domain which contains an RGG motif or the RNP domains were crit- ical for TDP-43 binding to DNA. ... See full document

... GIV sequence, and the other, DP348, contained the SIM sequence associated with resistance ...wild- type GIV sequence, not with the SIM-containing fusion ...this type of assay, both test ... See full document

... HIV-1 transduction to the same extent as MDM ...(Fig. 1 and ...of human emerin in mouse knockout cells did not detectably alter their susceptibility to HIV-1 infection ... See full document

... plasmid vector, we determined the nucleotide sequence of both DNA strands of each clone for each ...consensus sequence for the gag clones for each patient (data not shown). Sequence ... See full document