[PDF] Top 20 Within-sample co-methylation patterns in normal tissues
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Within-sample co-methylation patterns in normal tissues
... obtain methylation signals by ...processed methylation signal datasets ...processed methylation signals are not available ...processed methylation signal data, we find that the original ... See full document
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Antibody-based tissue profiling as a tool for clinical proteomics
... certain tissues, only a minority of present cells determines a specific function of a defined tissue, for example, islet cells in pancreatic tissue or glomerulus cells in kidney ...defined normal tissue, ... See full document
15
Original Article The expression patterns of gremlin 1 and noggin in normal adult and tumor tissues
... there are few examples of expression data in clinical patient material. Low level expression of noggin protein in combination with high BMP6 and low sclerostin expression associat- ed with poor prognosis in esophageal ... See full document
9
Altered Methylation at MicroRNA-Associated CpG Islands in Hereditary and Sporadic Carcinomas: A Methylation-Specific Multiplex Ligation-Dependent Probe Amplification (MS-MLPA)-Based Approach
... sporadically. Methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) assays were developed for 11 miRNA loci that were chosen because all could be epigenetically regulated through the ... See full document
10
<p>DNA methylation-mediated silencing of miR-204 is a potential prognostic marker for papillary thyroid carcinoma</p>
... the methylation status of promoter CpG islands of ...tumor tissues compared to the matched normal tissues (Table ...limited sample size of our study, data from TCGA database were used ... See full document
14
DACT2 silencing by promoter CpG methylation disrupts its regulation of epithelial-to-mesenchymal transition and cytoskeleton reorganization in breast cancer cells
... and normal tissues Breast cancer cell lines (BT549, MB231, MB468, MCF7, T47D, SK-BR-3, YCCB1, YCCB3 and ZR-75- 1) were ...used. Normal breast tissue RNA samples were purchased commercially ... See full document
12
DNA methylation at an enhancer of the three prime repair exonuclease 2 gene (TREX2) is linked to gene expression and survival in laryngeal cancer
... final sample size of 248 cases (age 36 to 80 ...Clinically normal head and neck mu- cosa samples from non-cancer patients who underwent tonsillectomy were obtained from the Department of ... See full document
15
MYOD 1 in normal colonic mucosa : role as a putative biomarker?
... DNA methylation profiling, where changes in methylation in tumour samples were classi- fied as age related as well as the cancer specific ...This methylation profile of multiple genes including ... See full document
5
Review Article Epigenetics and Epigenetic Alterations in Pancreatic Cancer
... attractive sample for clinical use, and the detection of cancer-associated changes in DNA (mutations, methylation, and rearrangements) in serum, has been reported [177, 178] (for review, see [179]), results ... See full document
17
Assessment of cholecystokinin 2 receptor (CCK2R) in neoplastic tissue
... to normal matched tissues of the same ...multiple normal tissues has been ...multiple normal tissue samples from esophagus, liver, lung, pancreas, stomach, spleen and ...and ... See full document
11
Identification of specific DNA methylation sites on the Y-chromosome as biomarker in prostate cancer
... DNA methylation levels of the 6 sites were caused by base pair mutations, we performed whole-genome sequencing of all 66 pairs of PCa tissues and adjacent normal ...PCa tissues, consistent ... See full document
11
DNA methylome profiling of human tissues identifies global and tissue specific methylation patterns
... DNA methylation patterns were studied in the following 17 somatic tissues: abdominal and sub- cutaneous adipose tissue, bone, joint cartilage, yellow and red bone marrow, coronary and splenic artery, ... See full document
14
Promoter hypermethylation and silencing of tissue factor pathway inhibitor 2 in oral squamous cell carcinoma
... TFPI-2 methylation profiling al- lows clinical samples to be discriminated, the difference in TFPI-2 mRNA expression between tumor and normal tissues was not as convincing as was expected (data not ... See full document
13
Mouse mammary tumor virus: specific methylation patterns of proviral DNA in normal mouse tissues.
... Analysis of RNAs extracted from GR/A liver, mammary tumor, testes, placenta, and spleen tissues demonstrated that MuMTV proviral hypomethylation need not reflect significant proviral tra[r] ... See full document
6
Quantitative analysis of DNA methylation at all human imprinted regions reveals preservation of epigenetic stability in adult somatic tissue
... DNA methylation has a particular impor- tance in establishing and maintaining mono-allelic imprinted gene ...located within defined gene regulatory elements - such as pro- moters and chromatin ...located ... See full document
13
CancerLocator: non invasive cancer diagnosis and tissue of origin prediction using methylation profiles of cell free DNA
... DNA methylation microarrays of solid tumor tissues to train the model due to the scar- city of whole-genome bisulfite sequencing data (WGBS) in the public ...DNA methylation arrays focus only on ... See full document
12
Comprehensive longitudinal study of epigenetic mutations in aging
... of methylation levels of A) cg02018277 (higily methylated outlier) and B) cg15057747 (lowly methylation ...The methylation levels of epigenetic mutations were greatly different to normal ... See full document
13
Measuring animal age with DNA methylation: from humans to wild animals
... Age estimation models based on CpG DNAm combine information from CpG sites that have the highest correlation of DNAm levels with age. These are calibrated using tissue samples from known-age individuals. Early ageing ... See full document
8
Epigenome-wide DNA methylation regulates cardinal pathological features of psoriasis
... between normal and diseased tissues. However, due to different methylation levels of different cell types, actual dif- ferential methylation might be averaged out and missed at higher ...the ... See full document
16
Epigenomics: Genome-Wide Study of Methylation Phenomena
... recruiting co-repressor complexes such as histone deacetylases (HDACs) to the site (reviewed by Robertson and Wolffe, ...transcriptional co- repressors and the histone deacetylase, HDAC1, via the bridging ... See full document
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