3-Methyladenine (3-MA)
Original Article Effect of autophagy inhibitor 3-methyladenine combined with TP chemotherapy on nasopharyngeal carcinoma and EGFR and VEGF levels in tissues
... of 3-methyladenine (3-MA) combined with docetaxel and cisplatin (TP) chemotherapy regimen on the treatment of nasopharyngeal carcinoma and expression levels of EGFR and VEGF in tissues from patients ...
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A model for 3 methyladenine recognition by 3 methyladenine DNA glycosylase I (TAG) from Staphylococcus aureus
... as 3-methyladenine (3-MeA) is an essential process in all living organisms and is catalyzed by the enzyme 3-MeA DNA glycosylase ...alkylated 3-MeA over the much more abundant ...
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Autophagy decreases alveolar macrophage apoptosis by attenuating endoplasmic reticulum stress and oxidative stress
... (3-methyladenine, 3-MA) or autophagy promoter (rapamycin), followed by hypoxia-reoxygenation treatment 2 h, 4 h or 6 h ...ml/kg 3-MA (5 μmol/L) lavage (3-MA group), and left lung hilum ...
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Vol 70, No 4 (2018)
... from 3-methyladenine (3-MA) or small interference RNA targeting Atg7 enhanced the 5-FU-induced ap- optosis and cytotoxicity in human colon cancer ...
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... and 3-MA-treated EAE ...group], 3-methyladenine (3-MA) (1.5 mg/kg) [EAE-3-MA group], or vehicle [EAE-Veh group] for 10 days from the 10 th day after the EAE ...
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Resistance to receptor tyrosine kinase inhibitors in solid tumors: can we improve the cancer fighting strategy by blocking autophagy?
... Sugita and colleagues [43] reported that gefitinib caused a strong induction of autophagy in the NSCLC cell line PC-9. Importantly, when they blocked autophagy with clarithromycin, an antibiotic known to block autophagic ...
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Distinct role of autophagy on angiogenesis: highlights on the effect of autophagy in endothelial lineage and progenitor cells
... 3-MA: 3-Methyladenine; AGEs: Advanced glycation end products; AMPK: Adenosine monophosphate kinase; ASCs: Adult stem cells; ATG: Autophagy-related genes; BAECs: Bovine aortic endothelial cells; CMA: ...
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Cell apoptosis, autophagy and necroptosis in osteosarcoma treatment
... inhibitor 3-methyl-adenine (3- MA) enhanced GA-induced apoptosis in KTHOS cells ...inhibitor 3-methyladenine, suggesting that autophagy may play a protective role that impedes eventual cell ...
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Cerebral ischemic damage in diabetes: an inflammatory perspective
... study, 3-methyladenine (3-MA; an autophagy inhibitor) treatment significantly lowered infarct volume, brain edema, and motor ...chain 3-II (LC3-II)—a marker of active autophagosomes and ...
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Neuroprotective coordination of cell mitophagy by the ATPase Inhibitory Factor 1
... of 3-Methyladenine (3-MA) and Chloroquine ...SH-SY5Y 3-MA IPC/ RX=0,216±0,013 SH-SY5Y ClQ IPC/RX=1,508±0,027 SH-IF 1 kd CTL=0,156±0,022 SH- IF 1 kd IPC/RX=0,388±0,026 SH-IF 1 kd 3-MA ...
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Suppression of autophagy enhances preferential toxicity of paclitaxel to folliculin-deficient renal cancer cells
... inhibition of MAPK pathway reduced autophagy in these cells. To further determine whether paclitaxel treatment induced autophagy represents synergistic antineoplastic effects on FCLN-deficient RCC cells or provides a ...
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Autophagy inhibition enhances RAD001-induced cytotoxicity in human bladder cancer cells
... Materials and methods: The cytotoxicity of RT4, 5637, HT1376, and T24 human bladder cancer cells treated with RAD001 alone or combined with autophagy inhibitors (3-methyladenine (3-MA), bafilomycin ...
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Epigenetic regulatory functions of DNA modifications: 5-methylcytosine and beyond
... (Figure 3), but might also play an impor- tant role in positively influencing transcription, either by recruiting methylation-specific transcription factors [82, 83] or by a yet to be understood mechanism when ...
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Vol 3, No 3 (2017)
... 3. The road creation (Figure 3) is generated only when the rooms are different. If the University rooms coincide, a message is displayed which sends the user a set of instructions. If the two rooms are ...
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1 (3 Chlorobenzoyl) 3 methyl 3 phenylthiourea
... Freshly prepared 3-chlorobenzoyl isothiocyanate (1.84 g, 10 mmol) was added to acetone (30 ml) and the mixture was stirred for 15 min. Neat N-methylaniline (1.07 g, 10 mmol) was then added and the resulting ...
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MfRANDAdx-3 MTRAI\TDA dX-3 MfRAIVDAdx-3 MfRANDAdx-3 MfRAI\TDA dx-3 IVIfRAMAdx-3 MfRANDAdx-3 IVIfRAIrIDA dx-3 MfRANDAdx-3 MfRAIVDAd*6e MTR
... EXPOSUREMETER SYSTEM TTL, zone lower center-weighted light measuring at open or closeddown aperture, CdS cell built into mirror assembly, lC circuitry comparator cross-coupled to shutter[r] ...
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Vol 3, No 3 (2011)
... When GTF solution containing 2, 4 and 6 g/ml were analysed by the proposed HPLC method for finding out intra- and inter-day variation, a low coefficient of variation was observed (Table 2). This shows that the present ...
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Vol 3, No 3 (2011)
... Swiss albino mice received the drug or vehicle orally for 10 days. On 10th day, a neutropenic dose of cyclophosphamide (200 mg/kg, s.c.) was administered and this day was labeled as day zero. Blood samples were collected ...
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Vol 3, No 3 (2017)
... A. The basics of development The application design process presented in this paper is a thorough one and requires a high level of research focusing on multiple fi[r] ...
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1 (3 Chlorobenzoyl) 3 (3 chlorophenyl)thiourea
... Cl2 0.0403 (4) 0.0368 (4) 0.0184 (3) 0.0001 (3) 0.0054 (3) −0.0087 (3) C1 0.0237 (13) 0.0203 (15) 0.0151 (12) −0.0025 (10) 0.0026 (9) −0.0009 (11) O1 0.0570 (12) 0.0210 (11) 0.0145 (10) ...
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