alternative pathway
Factor H Dependent Alternative Pathway Inhibition Mediated by Porin B Contributes to Virulence of Neisseria meningitidis
... N eisseria meningitidis is an important cause of bacterial men- ingitis and sepsis worldwide. The complement system is an important component of innate immune defenses against this pathogen. Individuals deficient in ...
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Structural studies of factor B of the alternative pathway of the complement system
... the alternative pathway of complement activation, much attention is being focused on structure-based drug design of novel small molecule inhibitors to factor D (Cole et ...
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An alternative pathway for alphavirus entry
... REVIEW Open Access An alternative pathway for alphavirus entry Joseph P Kononchik Jr, Raquel Hernandez and Dennis T Brown* Abstract The study of alphavirus entry has been complicated by an inability t[.] ...
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An alternative pathway for preclinical research in fluid management
... An alternative pathway of preclinical research might serve to reduce the risks and costs of developing therapies, thereby benefiting all partic- ipants in the healthcare ...this pathway consist of ...
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Induction of alternative pathway respiration by nitrate in Chlamydomonas
... determined through western blot analysis (data not shown). However, strains in which AOX was close to undetected using western blotting were very rare. Figure 3.1A shows an example of transformed cells re-plated onto ...
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Germline mutations in the alternative pathway of complement predispose to HELLP syndrome
... In the partial HELLP group there were 4 participants with adverse fetal outcomes, all of whom had either a positive mHam test or a rare germline variant, further indicating that abnor[r] ...
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De Novo purine biosynthesis by two pathways in Burkitt lymphoma cells and in human spleen
... alternative pathway for the synthesis of phosphoribosyl-1-amine from ribose-5-phosphate and ammonia was found to be subject to inhibition by the end products of the purine synthetic pathway, ...
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Activation of the Alternative Complement Pathway by Fungal Melanins
... Melanins are immunologically active molecules (1, 25, 27). Furthermore, melanization slightly increases the negative charge of C. neoformans cells (26) and affects their interaction with host effector cells (2, 37). ...
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Linkage Specificity and Role of Properdin in Activation of the Alternative Complement Pathway by Fungal Glycans
... Sera and complement reagents. Hemolytically active sera obtained from 10 healthy adults (normal human serum [NHS]) were pooled and stored at – 80°C until used. To permit selective activation of the alternative ...
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Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in mice
... the alternative pathway may be of particular importance in mediating neuroinflammation and neuro- nal cell death after head injury, based on studies in factor B gene knockout (fB-/-) mice ...
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Shigatoxin-associated hemolytic uremic syndrome: current molecular mechanisms and future therapies
... 50 Through study of these patients, it became clear that abnormal alternative pathway activation can lead to development of glomerular thrombotic microangiopathy, with consideration [r] ...
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Species Specificity of Vaccinia Virus Complement Control Protein for the Bovine Classical Pathway Is Governed Primarily by Direct Interaction of Its Acidic Residues with Factor I
... Both SPICE and VCP are secretory proteins but have the ability to bind to the infected cells via glycosaminoglycans (21). In addition, VCP has been shown to bind to the infected cells via the viral protein A56 (22). They ...
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A critical role for the NFkB pathway in multiple myeloma
... or alternative NFkB pathways selectively, but usually both pathways are activated in ...NFkB pathway leads to a similar response of MM cell ...the alternative pathway distinguishes MM from ...
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Schumann, Kerstin Monika (2012): Modulation of NF-kB signaling by measles Virus P gene products. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... The alternative pathway responds to signals of a selected set of receptors within the TNF superfamily such as lymphotoxin-β receptor (LTβR), B-cell activating factor receptor (BAFFR) and CD40 (Sun, ...of ...
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A structural study of human complement subcomponent C1s : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University
... A single proteolytic cleavage by either the classical pathway C3 convertase C4b,2a or the alternative pathway convertase C3b,Bb liberates a C3a activation peptide molecular wei ght 9,000[r] ...
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Altered renal tubular expression of the complement inhibitor Crry permits complement activation after ischemia/reperfusion
... alternative pathway. We hypothesized that selective activation of this pathway after renal I/R could occur either because of a loss of complement inhibition or from increased local synthesis of ...
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AMD and the alternative complement pathway: genetics and functional implications
... complement pathway have been linked to AMD and its pathological consequences [15, 16, 30, 64, 70, ...(classical pathway) or bacterial mannose groups (lectin pathway) and can also be active in a ...
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Complement-targeted therapy: development of C5- and C5a-targeted inhibition
... the alternative pathway of complement activation ...the alternative pathway of complement activation is activated in MPO- ANCA-associated nephritis, and a C5a receptor antagonist may be ...
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C3 glomerulopathy: consensus report
... the alternative pathway, typical cases do not show any deposition of immunoglobulin or of early components of the classical or lectin pathways, specifically C1q and ...
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Genetics and physiology of respiration in Aspergillus nidulans : a thesis presented in partial fulfilment of the requirements for the degree of Doctor in Philosophy in Molecular Genetics at Massey University, Palmerston North, New Zealand
... the alternative respiratory ...cytochrome pathway would lead to the accumulation of ...the alternative pathway under such conditions (section 1 ...the alternative pathway is ...
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