Alternative splicing
The Alternative Splicing Mutation Database: a hub for investigations of alternative splicing using mutational evidence
... the Alternative Splicing Mutation Database (ASMD) – a collection of human exon sequences with short (1–6 nucleotides) internal mutations that change the balance of alternatively spliced mRNA isoforms or ...
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Alternative splicing is required for stage differentiation in malaria parasites
... in alternative splicing, only ...in alternative splicing are common to both gametocyte ...in alternative splicing are ...in alternative splicing between female and ...
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The Function of Pre-mRNA Alternative Splicing in Mammal Spermatogenesis
... Alternative splicing coupled to nonsense- mediated mRNA decay (NMD) is an efficient strategy to regulate gene expression. The main feature of NMD is that the last exon generates a premature termination ...
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The landscape of alternative splicing in cervical squamous cell carcinoma
... Alternative splicing (AS) is a biological process by which different exons are joined together to generate a series of mRNA isoforms from a single primary ...
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The control of alternative splicing of the leucocyte common antigen (CD45)
... of splicing factors has been addressed in previous studies using domain- swap chimeras and deletion mutants of SR proteins (Caceres and Krainer, 1993; Chandler et ...constitutive splicing, it appears to be ...
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Identification and characterization of alternative splicing in parasitic nematode transcriptomes
... with alternative splicing Given the fact that in AS, both the patterns of splicing as well as the spliced exons themselves, tend to be evolutionarily conserved [53,54], we wanted to explore potential ...
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Therapeutic potential of antisense oligonucleotides as modulators of alternative splicing
... The use of antisense 2′-deoxyoligonucleotides as agents for specific downregulation of gene expression is now well established (1). Most commonly, the oligonucleotides base-pair with an mRNA target and mediate its ...
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Patterns of alternative splicing in response to cold acclimation in fish
... and alternative splicing as a result of cold acclimation across studies and species, it is remarkable the extent of divergence in specific differential expression or alternative splicing ...
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Diversification of the muscle proteome through alternative splicing
... associated alternative splicing events in muscle differentiation [65, 66, 79, ...specific splicing factors at distinct temporal stages of muscle homeostasis, the muscle-specific knockout of RBFOX1 ...
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Tau exon 10 alternative splicing and tauopathies
... Alternative splicing of pre-mRNA, the differential inclu- sion or exclusion of portions of a nascent transcript into the final protein-coding mRNA, is widely recognized to be a ubiquitous mechanism for ...
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R and Bioconductor solutions for alternative splicing detection
... Alternative splicing (AS) is a natural biological process that allows genetic materials from a single locus to produce more than one transcript. The functionality of the resulting isoforms can be grossly ...
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The Interplay of Temperature and Genotype on Patterns of Alternative Splicing in Drosophila melanogaster
... ABSTRACT Alternative splicing is the highly regulated process of variation in the removal of introns from premessenger-RNA ...of alternative splicing on the phenotype are well documented, but ...
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Functional coordination of alternative splicing in the mammalian central nervous system
... the alternative splicing (AS) levels of pairs of alternative exons belonging to the same genes was assessed using standard Spearman ...of alternative exons with correlated splicing ...
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Analysis of Cis-acting Regulatory Motifs Involved in Alternative Splicing
... Identification of cis-regulatory motifs has long been a hotspot in the study of alternative splicing. We propose a two-step approach: we first identify k-mer seed motifs by testing for enrichment and ...
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Functional coordination of alternative splicing in the mammalian central nervous system
... the alternative splicing (AS) levels of pairs of alternative exons belonging to the same genes was assessed using standard Spearman ...of alternative exons with correlated splicing ...
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Regulation and functional significance of CDC42 alternative splicing in ovarian cancer
... CDC42 is a major regulator of filopodia formation [20, 21] and has two isoforms (CDC42-v1 and CDC42-v2) that are generated through alternative splicing of the terminal exons. CDC42-v1 has exon 6A as the ...
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Alternative splicing: a mechanism for phenotypic rescue of a common inherited defect
... defect. Alternative splicing eliminates exon 2 in ...that alternative splicing of the primary transcript of human AMPD1 is controlled by tissue- specific and stage-specific ...signals. ...
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Differential gene expression and alternative splicing in insect immune specificity
... determining alternative splicing associated with the host-parasite genotype-genotype interaction at 24 hours post infection ...and alternative splicing after exposure to 2 strains of ...
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Comprehensive analysis of prognostic alternative splicing signature in cervical cancer
... the study of the occurrence and development of cancer through systems biology. Cervical cancer is considered a virus-driven cancer, and the human papilloma virus has been widely recognized as a causative factor for ...
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<p>Regulation of alternative splicing in obesity-induced hypertension</p>
... Alternative splicing of the mRNA coding for genes that play a role in metabolism gives rise to protein isoforms that play important and sometimes con fl icting roles in metabolic path- ...of ...
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