Anaphase-promoting complex
Multiple Subunits of the Caenorhabditis elegans Anaphase-Promoting Complex Are Required for Chromosome Segregation During Meiosis I
... Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or cyclosome ...
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The Anaphase-Promoting Complex/Cyclosome Is Required for Anaphase Progression in Multinucleated Ashbya gossypii Cells
... The anaphase-promoting complex/cyclosome (APC/C) is responsible for the protein destruction required for the initiation of anaphase and the exit from mitosis, including the degradation of ...
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Nuclear pore protein NUP88 activates anaphase promoting complex to promote aneuploidy
... In HeLa cells, altered expression of NUP88 has been associ- ated with multinucleation and centrosome amplification, linking NUP88 and mitosis through an unknown mechanism (4). These observations are in alignment with the ...
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Timing of anaphase promoting complex activation in mouse oocytes is predicted by microtubule kinetochore attachment but not by bivalent alignment or tension
... of anaphase-promoting complex/cyclosome (APC/C)-mediated cyclin B1 ...until anaphase onset was affected by the rate of loss of CDK1 activity, rather than by these non-aligned bivalents, which ...
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A Functional Analysis Reveals Dependence on the Anaphase-Promoting Complex for Prolonged Life Span in Yeast
... in anaphase-promoting complex (APC) activity, which regulates mitotic progression and chroma- tin assembly, results in genomic instability, a hallmark of premature aging and ...
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Mechanisms for the temporal regulation of substrate ubiquitination by the anaphase-promoting complex/cyclosome
... APC/C: anaphase-promoting complex/cyclo- some; BUB3: budding unihibited by benzimidazole 3; CAK: CDK activating kinase; CDK: cyclin dependent kinase; CKI: cyclin-dependent kinase inhibitor; CRL: ...
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The Anaphase Promoting Complex Regulates Yeast Lifespan and rDNA Stability by Targeting Fob1 for Degradation
... ABSTRACT Genomic stability, stress response, and nutrient signaling all play critical, evolutionarily conserved roles in lifespan determination. However, the molecular mechanisms coordinating these processes with ...
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Control the Host Cell Cycle: Viral Regulation of the Anaphase-Promoting Complex
... ligase anaphase-promoting complex (APC) that targets effector proteins for ubiquitination and proteasome ...through anaphase, exit from mitosis, and prevent a premature entry into S ...
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Dim1p Is Required for Efficient Splicing and Export of mRNA Encoding Lid1p, a Component of the Fission Yeast Anaphase-Promoting Complex
... the anaphase- promoting complex or cyclosome (APC/C) component Lid1p and thus for maintaining the steady-state level and activity of the ...tri-snRNP complex. Moreover, we find that Dim1p is ...
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The Spo12 Protein of Saccharomyces cerevisiae: A Regulator of Mitotic Exit Whose Cell Cycle-Dependent Degradation Is Mediated by the Anaphase-Promoting Complex
... the anaphase inhibi- anaphase inhibitor Pds1 is required for sister-chromatid tor Pds1, whereas Hct1/Cdh1 mediates the destruction separation and therefore the metaphase to anaphase of the mitotic ...
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The Anaphase Promoting Complex Contributes to the Degradation of the S. cerevisiae Telomerase Recruitment Subunit Est1p
... Telomerase is a multi-subunit enzyme that reverse transcribes telomere repeats onto the ends of linear eukaryotic chromosomes and is therefore critical for genome stability. S. cerevisiae telomerase activity is ...
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Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C).
... The anaphase promoting complex or cyclosome (APC/C) is a multi-subunit cullin-RING E3 ubiquitin ligase that functions to regulate progression through the mitotic phase of the cell cycle and to ...
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Asymmetric localisation of Miranda and its cargo proteins during neuroblast division requires the anaphase promoting complex/cyclosome
... Asymmetric cell divisions generate cell fate diversity during both invertebrate and vertebrate development. Drosophila neural progenitors or neuroblasts (NBs) each divide asymmetrically to produce a larger neuroblast and ...
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HTLV 1 Tax mutants that do not induce G1arrest are disabled in activating the anaphase promoting complex
... the anaphase inhibitor: securin/Pds1p (precocious dissociation of sister chromatids) were found to be significantly reduced ...the anaphase promoting complex/cyclosome (referred to as APC/C ...
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Mechanisms of ubiquitin transfer by the anaphase-promoting complex
... and complex ubiquitin-protein ligase called the anaphase-promoting complex or cyclosome (APC), which promotes the proteasomal destruction of key mitotic regu- lators in all eukaryotic cells ...
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Studies on the Contribution of Human Cytomegalovirus UL21a and UL97 to Viral Growth and Inactivation of the Anaphase-Promoting Complex/Cyclosome (APC/C) E3 Ubiquitin Ligase Reveal a Unique Cellular Mechanism for Downmodulation of the APC/C Subunits APC1, APC4, and APC5
... Human cytomegalovirus (HCMV) deregulates the cell cycle by several means, including inactivation of the anaphase-promoting complex/cyclosome (APC/C) E3 ubiquitin ligase. Viral proteins UL97 and ...
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Inactivation and Disassembly of the Anaphase-Promoting Complex during Human Cytomegalovirus Infection Is Associated with Degradation of the APC5 and APC4 Subunits and Does Not Require UL97-Mediated Phosphorylation of Cdh1
... the anaphase-promoting complex (APC) (8, 72, 79, 80), an E3 ubiquitin ligase that is responsible for the timely degradation of cell cycle proteins and mitotic cyclins to promote cycle progression ...
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Changes in the Localization of the Saccharomyces cerevisiae Anaphase-Promoting Complex Upon Microtubule Depolymerization and Spindle Checkpoint Activation
... The anaphase-promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase in the ubiquitin-mediated proteolysis pathway ...late anaphase, the Cdc23-GFP was also visualized along the length of ...
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In Vivo Characterization of the Nonessential Budding Yeast Anaphase-Promoting Complex/Cyclosome Components Swm1p, Mnd2p and Apc9p
... We have examined the in vivo requirement of two recently identified nonessential components of the budding yeast anaphase-promoting complex, Swm1p and Mnd2p, as well as that of the previously ...
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Accumulation of Substrates of the Anaphase-Promoting Complex (APC) during Human Cytomegalovirus Infection Is Associated with the Phosphorylation of Cdh1 and the Dissociation and Relocalization of APC Subunits
... the anaphase-promoting complex (APC), a multisubunit E3 ubiquitin ligase, and accumulation of its ...core complex itself would account for not only the observed inactivity but also its ...
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