BCR-ABL duplication and over expression
Subcellular localization of Bcr, Abl, and Bcr Abl proteins in normal and leukemic cells and correlation of expression with myeloid differentiation
... and expression of Bcr, Abl, and Bcr-Abl proteins in leukemic cell lines and in fresh human leukemic and normal samples at various stages of myeloid ...
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Bcr/Abl expression stimulates integrin function in hematopoietic cell lines
... oncogene Bcr/Abl has positive effects on VLA- 4 and VLA-5 integrin ...of Bcr/Abl in the GM-CSF- or IL-3-dependent hematopoietic cell lines MO7e, 32D, and BaF/3 enhanced cell binding to both ...
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E2A/PBX1, MLL/AF4, BCR/ABL (M-BCR), BCR/ABL(m-BCR) gene rearrangements in acute lymphoblastic leukemia in Iranian children
... In about 5% of children, E2A/PBX1 is expressed with early pre-B ALL and poor prognosis. In our data, E2A/PBX1 was present in only one (1.5%) child with early pre-B-ALL who achieved early hematological response with ...
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Analysis of BCR/ABL transcripts in healthy individuals
... of BCR/ABL in healthy subjects between 20 and 80 years of age, while Bose et ...subjects over 61 years of ...of BCR/ABL and its mechanisms of interaction with cellular components have ...
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BCR ABL KINASE INHIBITORS FOR CANCER THERAPY
... of Bcr-Abl expressing immortalized myeloid cells in vitro, findings in animal models of leukaemia suggest that whereas they appear to play a role in ALL, they may not be important in ...the Bcr- ...
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A Critical Role of CDKN3 in Bcr-Abl-Mediated Tumorigenesis
... Ectopic expression of CDKN3 significantly reduced the efficiency of Bcr- Abl-mediated transformation of FDCP1 cells to growth factor ...CDKN3 expression conferred resistance to ...
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BCR/ABL induces multiple abnormalities of cytoskeletal function
... the expression of the adhesion molecule LFA-3, which is decreased in CML cells ...of BCR/ABL-expressing cells and CML patient samples reverted the abnormal motility and morphology to a more normal ...
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IGF-IR determines the fates of BCR/ABL leukemia
... The expression of IGF-IR was dramatically higher on CML cells than on ALL ...in BCR/ABL + cells led to the development of ALL (mostly T-ALL) but not ...the BCR/ABL + CML cells. ...
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Effect of Ras Inhibition in Hematopoiesis and BCR/ABL Leukemogenesis
... in BCR/ABL-induced MPD but not lymphoid ...Discussion Expression of the N17 H-Ras transgene under the control of the E μ enhancer and the lck proximal promoter arrests B cell development at the pro-B ...
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Second generation inhibitors of BCR- ABL for the treatment of imatinibresistant
... Andreas Hochhaus is professor of internal medicine, haematol- ogy and oncology at the Medical Faculty Mannheim of Heidelberg University, Germany. He has been involved in randomized studies of the German CML Study Group ...
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Ablation of PI3K blocks BCR ABL leukemogenesis in mice, and a dual PI3K/mTOR inhibitor prevents expansion of human BCR ABL+ leukemia cells
... requirement for class IA PI3K in the murine pre–B-ALL model but has not distinguished the roles of different isoforms (5, 10, 29). Genetic ablation of Pik3r1 encoding p85α/p55α/p50α causes only partial inhibition of B ...
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Nickel pyrithione induces apoptosis in chronic myeloid leukemia cells resistant to imatinib via both Bcr/Abl-dependent and Bcr/Abl-independent mechanisms
... proteins. Expression levels of Bcr-Abl in CML cells were analyzed by using western blotting and real-time ...and Bcr-Abl-related proteins and protein biomarkers related to ...
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The analysis of Bcr-Abl—Nox signalling in chronic myeloid leukaemia
... p22phox expression in CML ...priming Bcr-Abl inhibition to produce a substantially greater effect on cell death demonstrating the clinical potential of targeting Nox proteins in combination with ...
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Localisation, activity and targeting of Bcr-Abl in chronic myeloid leukaemia
... the Bcr-Abl b2a2 junction specific antibody was validated by Western blotting, immunoprecipitation and immunofluorescence ...of Bcr-Abl protein in TKI resistant/persistent primary CML CD34 + ...
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Downregulation of Bcr-Abl oncogene in Chronic Myeloid Leukemia by microRNAs
... In order to eradicate Imatinib resistance, multiple strategies have been proposed at the protein level as well as the transcript level [6]. In October 2012, to cope up with the TKIs resistance, the US Food and Drug ...
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Bcr-abl Silencing by Specific Small-Interference RNA Expression Vector as a Potential Treatment for Chronic Myeloid Leukemia
... of Bcr-abl due to gene amplification [20] and point mutations, in the ABL kinase domain ...specific Bcr-abl targeting approach would be the clinical use of ...of Bcr-abl ...
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Activity of histone deacetylase inhibitors and an Aurora kinase inhibitor in BCR-ABL-expressing leukemia cells: Combination of HDAC and Aurora inhibitors in BCR-ABL-expressing cells
... in BCR-ABL-positive leukemia ...in BCR- ABL-positive K562 and mouse pro-B Ba/F3 cells with ectopic expression of wt and mutant ...
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Combination of Bortezomib and Mitotic Inhibitors Down-Modulate Bcr-Abl and Efficiently Eliminates Tyrosine-Kinase Inhibitor Sensitive and Resistant Bcr-Abl-Positive Leukemic Cells
... that Bcr-Abl is able to induce activation of multiple downstream pathways through phosphorylation of the CrkL adaptor protein, phosphorylation of Figure ...of Bcr-Abl in TKIs-resistant K562-R, ...
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Prognostic Features of BCR ABL Genetic Variations in Acute Lymphoblastic Leukemia
... [18] reported that CD10 expression had no statistical relationship with t(9; 22). On the other hand, there was high negative significant association (p = 0.000) between t(9; 22) and CD13 or 33 positive aberrant ...
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BCR ABL kinase is dead; long live the CML stem cell
... This is not to say that targeting the CML stem cell is impossible or should be cast off as a therapeutic goal. Eight-year survival for a previously uniformly fatal disease is a wonderful result of imatinib therapy, but ...
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