Binding Model of the Polyamide-DNA Complex
Structural and kinetic profiling of allosteric modulation of duplex DNA induced by DNA-binding polyamide analogues
... the DNA binding affinity, kinetics and se- quence-selectivity of hairpin polyamide analogues is de- ...scribed. DNA duplexes containing either target polyamide binding sites or ...
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Predicting DNA-binding proteins and binding residues by complex structure prediction and application to human proteome
... predicting DNA-binding function at the level of protein-DNA complex structures, rather than low-resolution two-state prediction of DNA-binding as most existing techniques ...
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Adenovirus DNA-binding protein forms a multimeric protein complex with double-stranded DNA and enhances binding of nuclear factor I.
... To study whether the binding of DBP could influence initiation of DNA replication, we analyzed the effect of DBP on the binding of nuclear factor I (NFI) and NFIII, two sequence-specific[r] ...
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Photocontrolled DNA Binding of a Receptor-Targeted Organometallic Ruthenium(II) Complex
... Scheme 1. Structure of the conjugates synthesized and sche- matic representation of the photodissociation process On this basis, we selected two relevant receptor-binding pep- tides that are expected to act as ...
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Photocontrolled DNA binding of a receptor targeted organometallic ruthenium(II) complex
... Scheme 1. Structure of the conjugates synthesized and sche- matic representation of the photodissociation process On this basis, we selected two relevant receptor-binding pep- tides that are expected to act as ...
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DNA BINDING AND NUCLEASE ACTIVITY OF STRUCTURALLY CHARACTERIZED COPPER(II) COMPLEX
... copper(II) complex [Cu(bpy) 2 (NO 3 )] NO 3 H 2 O (bpy = 2,2’-bipyridine) has been synthesized and characterized based on physico-chemical spectral ...The complex is characterized based on electronic, IR ...
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Self-Assembly of Model DNA-Binding Peptide Amphiphiles
... a model DNA-binding amphiphile, having a GCN4 peptide as the headgroup and containing a polymerizable methacrylic group in the tail region, using a combination of small-angle X-ray scattering, ...
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Separation of the complex DNA binding domain of EBNA-1 into DNA recognition and dimerization subdomains of novel structure.
... Comparison of binding of group II (485D and 511VY) and group IV (477A-SR and 467VD) polypeptides to mutant oligomer probes. Mobility shift assays were performed as described in the legen[r] ...
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Synthesis, DNA and Protein Binding and DNA Cleavage Activity of a Ferric (III) Complex Containing Novel TACN
... cleave DNA under physiological conditions are considered as potential candidates for use as therapeutic agents in medicinal applications and for genomic ...like DNA, proteins are also considered to be one ...
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Investigations of Pyrrole Imidazole Polyamide Effects on DNA Replication
... in polyamide treated ...antigen binding site that allows for reaction with larger 2’ halides in ZBU30 allows it recognize the unknown antigen in polyamide treated cells, while the ability to ...
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Evaluation of DNA-binding, cleavage, BSA interaction of Zn-hydroxy flavone complex
... of DNA-binding and behavior of the metal complexes as novel cancer therapeutic agents are strongly attributed to the size, shape, and planarity of the intercalative ...with DNA either covalently or ...
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DNA binding properties of a chemically synthesized DNA binding domain of hRFX1
... of DNA recognition by proteins of the RFX family, the DBD of hRFX1 (hRFX1/DBD) was chosen as a ...minimum DNA binding site in order to simplify study of the interaction of hRFX1/DBD with ...13mer ...
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DNA Damage Effects of A Polyamide-CBI Conjugate in SV40 Virions
... reversible binding in the DNA minor groove, but are incapable of inducing DNA ...a polyamide with a moiety of a DNA alkylating agent of the cyclopropylpyrroloindole (CPI) family, a ...
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Turnover of Hepatitis B Virus X Protein Is Regulated by Damaged DNA-Binding Complex
... Unité de Recombinaison et Expression Génétique (INSERM U163), Institut Pasteur, Paris, France Received 22 January 2002/Accepted 25 March 2002 Mammalian hepatitis B viruses encode an essential regulatory protein, termed ...
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A dsRNA-binding protein of a complex invertebrate DNA virus suppresses the Drosophila RNAi response
... Viral RNase III proteins are conserved among all gen- era within the Iridoviridae family, suggesting that this pro- tein has important functions within the viral life cycle (46). However, under our experimental ...
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Chromatin association of the SMC5/6 complex is dependent on binding of its NSE3 subunit to DNA
... /6 complex is essential for proliferation in yeast and is involved in replication fork stability and ...double-stranded DNA without any preference for DNA-replication/recombination inter- ...
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Genetic and biochemical identification of a novel single stranded DNA binding complex in Haloferax volcanii
... of DNA damage sensi- tivity, as did deletion of the rpa3 operon, suggesting that RPA3 and RPAP3 function in the same ...single-stranded DNA-binding complex that is unique to ...
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Prediction of DNA-Binding Proteins and their Binding Sites
... to model the data using features, and iv) Statistical and Probabilistic Analysis to empirically evaluate the model by comparative analysis and visualize the ...of DNA-binding proteins and ...
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An information transmission model for transcription factor binding at regulatory DNA sites
... (T,T)
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Thermodynamic analysis of DNA binding by a Bacillus single stranded DNA binding protein.
... 70 binding suggested that SSB BA forms a tetrameric assembly upon ssDNA ...for DNA binding through the formation of a transient tetrameric ...protein-DNA complex required in processes ...
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