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C. elegans

Transfer at C. elegans Synapses

Transfer at C. elegans Synapses

... Transmitter release at graded synapses is usually not only sustained, but also activated at low presynaptic voltages. Consequently, depolarization as well as hyper- polarization of the presynaptic neuron can cause ...

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URI 1 is required for DNA stability in C  elegans

URI 1 is required for DNA stability in C elegans

... To further investigate the potential effect of loss of uri-1 function on cell cycle progression, we examined the nuclear morphology of germline cells in wild-type, uri-1(lf) and uri-1(RNAi)F1 animals stained with DAPI ...

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Actin dependent cytoplasmic streaming in C  elegans
oogenesis

Actin dependent cytoplasmic streaming in C elegans oogenesis

... Because particle transport in animal and plant cells often requires microtubules and/or actomyosin, we asked whether either system was required for proximal streaming in the C. elegans gonad. Standard ...

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Insulin signaling promotes germline proliferation in C  elegans

Insulin signaling promotes germline proliferation in C elegans

... putative C. elegans insulin- like peptides (Pierce et ...of C. elegans genes with possible similarity to the extracellular domain of IIRs (Dlakic, ...the C. elegans genome, it ...

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Quantitative Insights into Developmental Signals and Phenotypes in C  elegans

Quantitative Insights into Developmental Signals and Phenotypes in C elegans

... In this manner, cis-regulatory elements serve as crucial points of signal integration. Significant advances have been made in uncovering the network of transcription factors and the cis-regulatory elements on which they ...

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Mathematical models of the developing C  elegans hermaphrodite gonad

Mathematical models of the developing C elegans hermaphrodite gonad

... wild-type C. elegans vulva is composed of 22 cells arranged in a compact dimpled structure located on the ventral portion of the worm slightly poste- rior to the midpoint between head and ...

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A C. elegans model to study human metabolic regulation

A C. elegans model to study human metabolic regulation

... Caenorhabditis elegans passes through four larval stages; L1, L2, L3, and L4 before reaching ...development, C. elegans exhibits food seeking behavior and hunts for easy to eat ...[64]. C. ...

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Analysis of centriole elimination during C  elegans oogenesis

Analysis of centriole elimination during C elegans oogenesis

... In C. elegans, the loss of MTOC function early during oogenesis, followed by centriole elimination at a later time, can also be viewed as two redundant mechanisms ensuring that no microtubule organizing ...

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On predicting regulatory genes by analysis of functional networks in C. elegans

On predicting regulatory genes by analysis of functional networks in C. elegans

... To test our algorithm on a larger set of highly interconnected and co-expressed genes we selected a group of genes involved in translation that had a strong co-expression pattern in two C.elegans strains [15–17]. The ...

16

Investigating C  elegans development through mosaic
analysis

Investigating C elegans development through mosaic analysis

... element that carries the wild-type allele of a gene in an otherwise homozygous mutant background. When the extrachromosomal element – and the wild-type gene carried by it – is present in all cells, the worm exhibits a ...

8

Characterization of taurine as anti-obesity agent in C. elegans

Characterization of taurine as anti-obesity agent in C. elegans

... mammals, C. elegans accumulates fat both from its diet and via de novo biosynthesis, and stores lipids in subcellular ...how C. elegans acquires, synthe- sizes, uses, and stores lipids, but ...

6

Regulation of Tissue-Specific Expression in the C. Elegans Embryo

Regulation of Tissue-Specific Expression in the C. Elegans Embryo

... We extracted total RNA from each cell population using a RNAeasy kit (Qiagen), amplified the poly-A RNA using a T7 RNA polymerase aRNA protocol (Ambion MessageAMP II aRNA kit), and sequenced cDNA using SoLID sequencing, ...

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Acto myosin reorganization and PAR polarity in C  elegans

Acto myosin reorganization and PAR polarity in C elegans

... in C. elegans embryos, centrosomes are essential for polarity establishment (Cowan and Hyman, ...one-cell C. elegans embryos: sperm- and ...

9

Run on of germline apoptosis promotes gonad senescence in C  elegans

Run on of germline apoptosis promotes gonad senescence in C elegans

... increases C. elegans lifespan [34] and delays reproductive senescence [35, 36] and gonad degeneration [20, ...influence C. elegans reproductive aging, particularly TGF-β Sma/Mab signalling ...

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Identification of functional long non-coding RNAs in C. elegans

Identification of functional long non-coding RNAs in C. elegans

... of C. elegans from the ex utero egg stage to the egg-laying adult stage (~ 65 ...40 C. elegans nematodes in 16-mm circular arenas continuously at 1 Hz for ~ 3 ...

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Regulation of maternal Wnt mRNA translation in C  elegans embryos

Regulation of maternal Wnt mRNA translation in C elegans embryos

... during C. elegans early embryogenesis (Rocheleau et ...when C, the somatic daughter of P2, signals ABar ...from C orients the division axis of ABar toward C (Park and Priess, 2003; ...

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Laminin is required to orient epithelial polarity in the C  elegans pharynx

Laminin is required to orient epithelial polarity in the C elegans pharynx

... the C. elegans intestine, the asymmetric localization of centrosomes and of PAR-3 complex proteins are early markers of apical polarity (Buendia et ...live C. elegans embryos expressing a PPC ...

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State Dependent Regulation of the Neural Circuit for C. Elegans Feeding

State Dependent Regulation of the Neural Circuit for C. Elegans Feeding

... While optogenetic tools have played an important role in clarifying the functional dynamics of identified neural networks, to my knowledge they have not been previously used to identify new functional roles of circuit ...

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Automated Vision Based Force Measurement of Moving C  elegans

Automated Vision Based Force Measurement of Moving C elegans

... There have been few systems for measuring forces of C. elegans. A silicon piezoresisitve cantilever [3] has been fabricated to characterize the mechanics of C. elegans body tissue. ...

6

Identification of novel cell death regulators in C  elegans and Drosophila

Identification of novel cell death regulators in C elegans and Drosophila

... nature of the apoptotic machinery and laid the foundation for subsequent studies in other invertebrates and mammals (reviewed in Aravind et al., 2001; Danial and Korsmeyer, 2004). Part of a broad family, CED-3 encodes a ...

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