cell activation
Mast cell activation disease: a concise practical guide for diagnostic workup and therapeutic options
... mast cell activation disease (Table 4) which may present mast cell mediator-induced symptoms by activation of normal mast cells ...mast cell media- tor release syndrome must lie in the ...
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TLR dependent T cell activation in autoimmunity
... T cell activation 1-2 ...T cell-promoting cytokines 1 , using distinct signaling pathways ...1). Activation of NF-κB results in production of the pro-inflammatory cytokines, including tumour ...
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T cell–independent B cell activation induces immunosuppressive sialylated IgG antibodies
... have suppressive feedback effects, as was previously suggested for IgM Abs in a different context (1, 41, 49–53). In the present study, a desialylated monoclonal anti-TNP IgM Ab enhanced TNP-Ficoll– induced B cell ...
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The role of phospholipase A2 in mast cell activation
... The effects of PLA 2 on mast cell activation have been contradictory. Some studies have indicated that the cells secreted histamine whilst others have shown no effects of applying the enzyme^^®°^ Recent ...
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Mutation of a diacidic motif in SIV PBj Nef impairs T cell activation and enteropathic disease
... sine-based activation motif (ITAM) important for cell activation processes, located at the amino-terminus of Nef, has been described as one of the genetic determi- nants of SIV-PBj pathogenicity ...
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B cell activation factor (BAFF) induces inflammation in the human fallopian tube leading to tubal pregnancy
... Background: Tubal pregnancy is recognized as one of the most common ectopic pregnancy types. Salpingitis may result in tubal pregnancy by causing fallopian tube occlusion and hydrosalpinx. B cell activation ...
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Modelling T cell activation
... cytoskeleton. Activation of the PI pathway results in release of Ca^+ from intracellular stores and this drives the translocation of cytoplasmic nuclear factor of activated T cells (NFAT) into the nucleus, where ...
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Utility of hydroxyurea in mast cell activation syndrome
... of MC disease manifesting inappropriate mediator re- lease with little to no accompanying proliferation of MCs [25]. This theory appeared validated when the first recognized cases of what is now called MC ...
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Regulation of polymorphonuclear cell activation by thrombopoietin
... leukemic cell lines ...other cell types of the he- mopoietic ...PMN. Cell lysates from PMN or platelets were im- munoprecipitated with an anti–c-Mpl antiserum raised against the intracellular domain ...
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Specific T cell activation in an unspecific T cell repertoire
... The next step is to understand how sensitively the diversity (which can be deter- mined experimentally, in principle) depends on the various random influences that drive the size of any given clone up or down. A ...
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Studies of T cell activation in chronic inflammation
... by Src family kinases, notably Lck and Fyn [61]. In con- trast to CD3 chains, which contain just one ITAM, TCR ζ carries three, providing the TCR/CD3 complex with a signal sensor and amplification module [62,63]. In ...
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Involvement of proteases and kinases in mast cell activation
... The actual mechanism by which PTK regulates PLC, as a result o f FcgRI phosphorylations, has been the subject o f intensive study. It has been shown that mast cells may contain more than one PLC isoenzyme^^^^^ and that ...
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CD39 Modulates Endothelial Cell Activation and Apoptosis
... EC activation has been considered to represent increased or de novo expression of proinflammatory factors, including the leuko- cyte adhesion molecule E-selectin ...EC activation and the conse- quent ...
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PD-1 and PD-L1 correlated gene expression profiles and their association with clinical outcomes of breast cancer
... T cell activation, lymphocyte activation, leukocyte migration while PD-L1 correlated genes demonstrated enrichment including T cell apoptotic process, tolerance induction and ...
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NK1 1 receptor ligation or tumour interactions prime NK cells for IL2 mediated metabolic and functional responses
... tumour cell metabolism serves them a dual purpose by making the TME extremely ...to activation, in order to elicit an effective ...small cell lung carcinoma show an altered phenotype with reduced ...
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Studies on the synergistic protective activity of cancer antigens associated to engineered bacterial Outer Membrane Vesicles
... T cell engineering platforms (Figure 3): (i) genetic manipulation of autologous T cells with TCRα and ß chains conferring high specificity for selected tumor epitopes, and (ii) T cell manipulation with ...
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Differential proteomics analysis of low- and high-grade of astrocytoma using iTRAQ quantification
... analysis, cell survival, cell viability, cell activation, cell proliferation, cell migration, cell invasion, cell movement and angiogenesis were increasingly ...
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Antigen-Dependent and -Independent Mechanisms of T and B Cell Hyperactivation during Chronic HIV-1 Infection
... B cell activation with non-HIV ...T cell activation in HIV infection, it is conceivable that it also impacts systemic B cell hyperactivation, perhaps even in an antigen-dependent ...B ...
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Defective expression of gp180, a novel CD8 ligand on intestinal epithelial cells, in inflammatory bowel disease
... Previous studies support a role for intestinal epithelial cells (IEC) as antigen-presenting cells in mucosal immune re- sponses. T cells activated by IEC are CD8 1 , suppressor in function, and dependent upon ...
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CD200 ligand receptor interaction modulates microglial activation in vivo and in vitro: a role for IL 4
... It has become increasingly clear that inflammation, which is ac- companied by impairment in neuronal function, is a feature of several neurodegenerative disorders, such as Alzheimer’s disease (AD) and multiple sclerosis ...
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