checkpoint kinase
Chemogenetic profiling identifies RAD17 as synthetically lethal with checkpoint kinase inhibition
... another checkpoint kinase known to complement CHEK1-mediated regulation of cell cycle, also displayed a strong synthetic lethal interaction with AZD7762 [11, 12, ...
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Overexpression of the Drosophila ATR homologous checkpoint kinase Mei-41 induces a G2/M checkpoint in Drosophila imaginal tissue
... Aiming for a deeper understanding of the Drosophila DNA damage response, we concentrated on meiotic 41 (mei-41), the Drosophila checkpoint kinase ATR homologue and key player of this process [24, 25]. To ...
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Efficacy of Combined Histone Deacetylase and Checkpoint Kinase Inhibition in a Preclinical Model of Human Burkitt Lymphoma
... Checkpoint kinase inhibition has been studied as a way of enhancing the effectiveness of DNA-damaging ...and checkpoint kinase 2 (CHEK2) inhibitor II in vitro and in ...and checkpoint ...
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Checkpoint kinase inhibitor AZD7762 strongly sensitises urothelial carcinoma cells to gemcitabine
... repair. Checkpoint signalling following DNA damage is initiated by the proximal kinases, ataxia telangiectasia mutated (ATM) or ataxia telangiectasia and RAD3-related (ATR) ...protein kinase complex is ...
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Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Can Induce Chromosomal Instability through Targeted Degradation of the Mitotic Checkpoint Kinase Bub1
... and kinase domains of Bub1 are important for its interaction with ...the kinase do- FIG 1 Bub1 levels are downregulated in cells latently infected with KSHV and expressing ...
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A Role for the Swe1 Checkpoint Kinase During Filamentous Growth of Saccharomyces cerevisiae
... Lew, D. J., T. Weinert and J. R. Pringle, 1997 Cell cycle control Shulewitz, M. J., C. J. Inouye and J. Thorner, 1999 Hsl7 localizes in Saccharomyces cerevisiae: cell cycle and cell biology, pp. 607–695 to a septin ring ...
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Checkpoint kinase inhibitor AZD7762 enhance cisplatin-induced apoptosis in osteosarcoma cells
... This result indicated that AZD7762 reduces arrest of G2/M phase mediated by cisplatin through regulating the cell cycle checkpoint protein expression.... 1 AZD7762 enhance the effect[r] ...
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A conserved Polϵ binding module in Ctf18 RFC is required for S phase checkpoint activation downstream of Mec1
... S-phase checkpoint, which produces a multifaceted response that preserves genome integrity at stalled DNA repli- cation ...the checkpoint kinase Rad53, which then mediates much of the ...
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Morphogenesis and the Cell Cycle
... morphogenesis checkpoint do so through at least two separate ...the checkpoint kinase Hsl1p is a key regulator whose activity is responsive to septin organization, to the cell shape change that ...
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Systematic analysis of somatic mutations driving cancer: uncovering functional protein regions in disease development
... Moving towards lower significance levels, the list of novel cancer genes becomes more populated. Altogether, 23 novel genes are identified by iSiMPRe with medium significance level, 18 of which are included in only one ...
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Activation of the Chicken Anemia Virus Apoptin Protein by Chk1/2 Phosphorylation Is Required for Apoptotic Activity and Efficient Viral Replication
... FIG 1 Treatment with the pan-Chk inhibitor AZD7762 impairs nuclear localization of apoptin in a dose-dependent manner. (A) Schematic of 3 ⫻ Flag-apoptin showing possible Chk1 and Chk2 phosphorylation sites (not drawn to ...
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Chk’ing p53 deficient breast cancers
... Loss or functional impairment of p53 occurs in many human cancers, and its absence is often associated with a poor response to conventional che- motherapy. Hence, much effort is currently devoted to developing novel ...
5
Mec1 Dependent Phosphorylation of the Scc3 Subunit of Cohesin during Mitosis in Budding Yeast
... mec1 kinase-dead mutation from MEC1 genomic locus (Figure ...Rad17-Mec3-Ddc1 checkpoint complex and altogether prevents activation of the DNA damage checkpoint kinase ...damage ...
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Contributions of DNA2 and the Tim/Tipin Complex to Genomic Stability
... Cdc7 kinase and the ATR checkpoint kinase, yet there was no observable change in Tim phosphorylation upon DNA damage checkpoint induction or incubation with the active Cdc7 kinase ...
155
The ENCCA-WP7/EuroSarc/EEC/PROVABES/EURAMOS 3rd European Bone Sarcoma Networking Meeting/Joint Workshop of EU Bone Sarcoma Translational Research Networks; Vienna, Austria, September 24–25, 2015. Workshop Report
... threonine kinase‑checkpoint kinase 1; AXL: AXL receptor tyrosine kinase; BCOR: BCL6 co‑repressor; BRCA1/2: breast cancer 1/2, early onset; BRD: bromodomain‑containing proteins; CCNB3: cyclin ...
9
Ataxia telangiectasia and Rad3-related inhibitors and cancer therapy: where we stand
... (ATM) checkpoint kinase 2 (CHK2) and ataxia telangiectasia and Rad3-related (ATR) checkpoint kinase 1 (CHK1) signals are two key pathways to initiate ...ATM-CHK2 kinase, which stabi- ...
8
New combinatorial strategies to improve the PARP inhibitors efficacy in the urothelial bladder Cancer treatment
... CHK1: Checkpoint kinase 1; CHK2: Checkpoint kinase 2; DDR: DNA damage response and repair; DNMT: DNA Methyl transferase; DSBs: Double strand breaks; ERVs: Endogenous retroviral sequences; ...
9
Pharmacological Inhibition of the DNA Damage Checkpoint Prevents Radiation-Induced Oocyte Death
... Figure 2 Concentration-dependent protection of irradi- ated oocytes by CHK2iII. (A) Schematic of CHK2iII treat- ment regimen, beginning with placing explanted 5 dpp ovaries into culture. Blue droplets denote times at ...
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Regulation of DNA Replication Machinery by Mrc1 in Fission Yeast
... inhibited, checkpoint regulation is believed to stabilize the replication fork; the detailed mechanism, however, remains ...damage checkpoint kinase, and were defective in full activation of Cds1, a ...
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Curcumin and its Allied Analogues: Epigenetic and Health Perspectives – a Review
... 2017 Lowered the content of mtDNA and enhanced the content of Cyt B and NADH5 in spermatozoa Decreased the expression of phospho p-p38, p-checkpoint kinase 1 ChK1, cyclin D1, and breast [r] ...
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