Complement receptor
Complement receptor 2–mediated targeting of complement inhibitors to sites of complement activation
... abundant complement opsonins found at sites of complement activation, and they serve as ligands for various C3 ...such receptor, complement receptor 2 (CR2), plays an important role in ...
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Neutrophils Interact with Adenovirus Vectors via Fc Receptors and Complement Receptor 1
... classical complement pathway) or serum heated at 50°C (to inactivate the alternative comple- ment pathway) (5, 13, ...and complement acti- vation, these results suggest that the classical complement ...
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Expression of a Functional Single-Chain Variable-Fragment Antibody against Complement Receptor 1 in Streptococcus gordonii
... Antigen targeting to immune cells has the potential to ma- nipulate the immune system and elicit an immune response more efficiently. Monoclonal immunoglobulin G (IgG) anti- bodies have long been used as specific ...
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Association of the Single Nucleotide Polymorphism and Haplotype of the Complement Receptor 1 Gene with Malaria
... erythrocyte complement receptor type 1 (CR1) in patients with malaria have been extensively studied, a question of whether the polymorphisms of CR1 are associated with severe malaria remains controver- ...
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Immunoglobulin bearing and complement receptor lymphocytes constitute the same population in human peripheral blood
... essentially all cells with integral surface immunoglobulin from normal human peripheral blood bear receptors for the third component of complement. Moreover, after removal of phagocytes, all cells with ...
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Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya
... of complement receptor 1 (CR1*1, F ...30 complement control protein repeats (CCPs; vertical boxes numbered 1–30) arranged into four long homologous regions (LHRs) A-D, each composed of seven ...three ...
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Complement receptor 1 gene (CR1) intragenic duplication and risk of Alzheimer’s disease
... the complement receptor 1 (CR1) gene show some of the strong- est genome-wide association signals with late-onset Alzheimer’s ...of complement C3b/C4b-binding sites in the mature ...
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Detachment of Human Immunodeficiency Virus Type 1 from Germinal Centers by Blocking Complement Receptor Type 2
... and complement frag- ments are trapped on the surface of FDC in form of immune- complex-coated bodies or “iccosomes” that contribute to B-cell maturation and B-cell memory ...of complement receptor 1 ...
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Complement receptor 1 gene (CR1) intragenic duplication and risk of Alzheimer’s disease
... the complement receptor 1 (CR1) gene show some of the strongest genome-wide association signals with late-onset Alzheimer’s ...of complement C3b/C4b-binding sites in the mature ...
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CD14 Targets Complement Receptor 3 to Lipid Rafts during Phagocytosis of Borrelia burgdorferi
... Phagocytosis of Borrelia burgdorferi, the causative agent of Lyme disease, is mediated partly by the interaction of the spirochete with Complement Receptor (CR) 3. CR3 requires the GPI-anchored protein, ...
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Pilus Adhesin RrgA Interacts with Complement Receptor 3, Thereby Affecting Macrophage Function and Systemic Pneumococcal Disease
... ABSTRACT Pneumococcal pili have been shown to influence pneumococcal colonization, disease development, and the inflam- matory response in mice. The role of the pilus-associated RrgA adhesin in pneumococcal interactions ...
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Molecular Basis of the Interaction between Complement Receptor Type 2 (CR2/CD21) and Epstein-Barr Virus Glycoprotein gp350
... The binding of the Epstein-Barr virus glycoprotein gp350 by complement receptor type 2 (CR2) is critical for viral attachment to B lymphocytes. We set out to test hypotheses regarding the molecular nature ...
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Polymorphism of the complement receptor for C3bi
... RM2.184, a mouse IgG2a monoclonal antibody, recognizes a polymorphic determinant on the complement receptor for C3bi which is present on granulocytes and monocytes.. The RM2.184 epitope [r] ...
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Molecular Structure and Expression of Anthropic, Ovine, and Murine Forms of Complement Receptor Type 2
... Complement receptor type 2 (CR2), also called CD21, is a cell surface glycoprotein expressed on the surfaces of mature human B lymphocytes, follicular dendritic cells (FDCs), a few T cells, and some ...
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Complement receptor-3 negatively regulates the phagocytosis of degenerated myelin through tyrosine kinase Syk and cofilin
... Syk-dependent downregulation of CR3- but not SRA- mediated phagocytosis of C3bi-opsonized and unopso- nized myelin is suggested by the following observations. First, Syk was continuously phosphorylated, thus con- ...
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Selective and marked decrease of complement receptor C5aR2 in human thoracic aortic aneurysms: a dysregulation with potential inflammatory effects
... this receptor as an anti- inflammatory receptor indicate that the func- tional consequences of C5aR2 downregulation in TAA may enhance the inflammatory effects induced by C5aR1, which was preserved in the ...
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Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T lymphocyte proliferation
... gC1qR (p33) binds to the globular head regions of C1q, whereas the cC1q receptor (p66) binds to the collagen- like stalk regions of the C1q molecule (27). Each of the six clones was confirmed to be present in the ...
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The swain-langley and McCoy blood group polymorphisms of complement receptor 1: role in severe plasmodium falciparum malaria
... This case-control study sought to establish any associations between McCb and SI2 and severe forms of malaria (cerebral malaria and severe malarial anaemia). 03) than individuals with th[r] ...
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Complement receptor C3aR1 controls neutrophil mobilization following spinal cord injury through physiological antagonism of CXCR2
... deregulated complement system activation following trauma can increase host tissue damage, impair wound healing, and lead to unfavorable outcomes ...inhibit complement at the level of C1q (31), factor B ...
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Complement receptor expression on neutrophils at an inflammatory site, the Pseudomonas infected lung in cystic fibrosis
... A pattern of receptor expression similar to that observed on inflammatory PMN could be reproduced in vitro by treating FMLP-stimulated isolated peripheral blood cells with a variety of p[r] ...
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