Complement receptor 1 (CD 35)
Expression of a Functional Single-Chain Variable-Fragment Antibody against Complement Receptor 1 in Streptococcus gordonii
... Antigen targeting to immune cells has the potential to ma- nipulate the immune system and elicit an immune response more efficiently. Monoclonal immunoglobulin G (IgG) anti- bodies have long been used as specific ...
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Complement receptor 1 polymorphisms associated with resistance to severe malaria in Kenya
... of complement receptor 1 (CR1*1, F ...30 complement control protein repeats (CCPs; vertical boxes numbered 1–30) arranged into four long homologous regions (LHRs) A-D, each ...
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Complement receptor 1 gene (CR1) intragenic duplication and risk of Alzheimer’s disease
... the complement receptor 1 (CR1) gene show some of the strongest genome-wide association signals with late-onset Alzheimer’s ...of complement C3b/C4b-binding sites in the mature ...
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Neutrophils Interact with Adenovirus Vectors via Fc Receptors and Complement Receptor 1
... classical complement pathway) or serum heated at 50°C (to inactivate the alternative comple- ment pathway) (5, 13, ...and complement acti- vation, these results suggest that the classical complement ...
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Complement receptor 1 gene (CR1) intragenic duplication and risk of Alzheimer’s disease
... the complement receptor 1 (CR1) gene show some of the strong- est genome-wide association signals with late-onset Alzheimer’s ...of complement C3b/C4b-binding sites in the mature ...
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Measurement of complement receptor 1 on neutrophils in bacterial and viral pneumonia
... via complement receptors and/or ...of complement receptors (CR1 and CR3) and Fcγ-receptors (FcγRI, FcγRII, and FcγRIII) on neutrophils or monocytes would be of value in differentiating between bacterial and ...
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Association of the Single Nucleotide Polymorphism and Haplotype of the Complement Receptor 1 Gene with Malaria
... 3. Mackintosh CL, Beeson JG, Marsh K. Clinical features and pathogenesis of severe malaria. Trends Parasitol 2004;20:597-603. 4. Stoute JA, Odindo AO, Owuor BO, Mibei EK, Opollo MO, Wait- umbi JN. Loss of red blood ...
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Plasmodium falciparum malaria and invasive bacterial co infection in young African children: the dysfunctional spleen hypothesis
... cell receptor: BCR), IgD, CD1c, CD35 (complement receptor 1 (CR1)), CD21 (complement receptor 2 (CR2)), CD27, high levels of Toll-like receptors (TLR), MHC class II, and TACI (an ...
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The role of the complement and the FcγR system in the pathogenesis of arthritis
... The complement system contributes to immune complex (IC) clearance by complement receptor 1 (CR1)-dependent and CR3-dependent phagocytosis, cell lysis by the terminal membrane attack complex, ...
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Complement regulatory protein Crry deficiency contributes to the antigen specific recall response in experimental autoimmune myasthenia gravis
... of complement receptor 1-related gene/protein y deficiency (Crry −/− ) on EAMG ...C3 complement component and protect self-tissues from complement mediated lysis ...phase ...
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In vivo handling of soluble complement fixing Ab/dsDNA immune complexes in chimpanzees
... within 1 h). These IC also bound rapidly to E in vivo (70-80% binding within 1 min) and did not show detectable release from E in the peripheral circulation after infusion in vivo (less than or equal to 2% ...
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Complement regulator CD46: genetic variants and disease associations
... Pathogens target different domains of CD46 for attach- ment and subsequent reactions. The adenovirus fiber- knob protein and measles virus hemagglutinin attach to CCPs 1 and 2. Measles-virus binding elicits ...
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Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer’s disease
... NDEVs isolated from AD patients also have a signifi- cant increase in soluble Aβ1–42 [41, 51–55]. Notably, NDEVs isolated from AD patients have increased levels of C-terminal fragments of the APP as well [45, 49]; ...
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Surface markers of complement receptor lymphocytes
... bearing complement receptors (CRL) were divided into two populations, one expressing both CR1 (C4b-C3b receptor) and CR2 (C3d receptor) and a second expressing only ...
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Complement C5a Receptor 1 Exacerbates the Pathophysiology of N meningitidis Sepsis and Is a Potential Target for Disease Treatment
... of 1; ⱖ 5% to 10% loss of body weight, score of 5; ⱖ 10% to 20% loss of body weight, score of 10; ⱖ 20% loss of body weight, score of 20; mildly aberrant general condition, score of 1; dull coat, mild lack ...
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Role of the complement system in the tumor microenvironment
... The complement system participates in mediating EMT in multiple tumor mod- ...inhibit complement pathways may be a promising method to inhibit EMT and limit dis- tant ...
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Combined inhibition of complement and CD14 improved outcome in porcine polymicrobial sepsis
... combined complement- and CD14-inhibitory regimen “post challenge” indicates that a “therapeutic window” might exist [39], though an efficient effect of delayed treatment in vivo remains to be ...
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Original Article Notch-1 and Ki-67 receptor as predictors for the recurrence and prognosis of Kimura’s disease
... Abstract: Kimura’s disease (KD) is a rare chronic disease with unknown origin. It remains controversial in KD’s diag- nosis, treatment, transformation and need further research. The aim of this study is to investigate ...
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Parasite-host interaction in malaria: genetic clues and copy number variation
... The life cycle of all Plasmodia species is very similar and follows basically the same process (Figure 1). Development involves a host change from an arthropod vector to a vertebrate host (the female Anopheles ...
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To be or not to be B7
... The activation of lymphocytes and development of adaptive immune responses is initiated by the engagement of TCRs by antigenic peptide–MHC complexes and shaped at the clonal level by both positive and negative ...
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