complex diseases
Dynamic Bayesian Testing of Sets of Variants in Complex Diseases
... ABSTRACT Rare genetic variants have recently been studied for genome-wide associations with human complex diseases. Existing rare variant methods are based on the hypothesis-testing framework that predefined ...
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A comparison of genomic profiles of complex diseases under different models
... 7 complex diseases from the WTCCC from genome-wide ...two diseases with a high genetic component (rheumatoid arthritis and Type 1 diabetes) did certain models achieve a high enough predictive ...
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A novel approach to simulate gene environment interactions in complex diseases
... case-parent studies and does not actually produce simu- lated data sets. In QUANTO the disease risk is a function of a one gene-one environment interaction. Moreover, in QUANTO the user can input the risks associated to ...
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Sibship T2association tests of complex diseases for tightly linked markers
... The goal of this study was to develop sibship-based Hotelling’s T 2 test statistics for high-resolution association mapping of complex diseases. This extends our previous research of paired Hotelling’s T 2 ...
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Prioritization and functional assessment of noncoding variants associated with complex diseases
... of complex traits [11, ...inherited diseases; however, this premise may not hold in all cases, such as those in which the variants increase the risk for post-reproductive diseases ...various ...
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Statistical Methods in Mapping Complex Diseases
... Genome-wide association studies (GWAS) offer a powerful tool to identify genes that confer moderate disease risks. In these studies, the main outcome of interest is often disease status. However, in many of these ...
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Searching for genes in complex diseases: lessons from systemic lupus erythematosus
... Mendelian diseases, it has been much less so for identifying genes for common, complex ...for complex diseases is much greater in animal models than in humans, for a variety of ...
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Knowledge and attitudes to personal genomics testing for complex diseases among Nigerians
... Advances in medical technologies have made genomics tests that predict risk of diseases increasingly available for use in clinical settings. With the substantial reduc- tion in cost and its rapid spread around the ...
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<p>Potential Impact of the Multi-Target Drug Approach in the Treatment of Some Complex Diseases</p>
... process. However, the recent Food and Drug Administration (US) approval of pretomanid represents the third anti-TB drug in 50 years. The triple combination of bedaquiline, pretomanid and linezolid has been reported as a ...
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The cultural epigenetics of psychopathology: The missing heritability of complex diseases found?
... We extend a cognitive paradigm for gene expression based on the asymptotic limit theorems of information theory to the epigenetic epidemi- ology of mental disorders. In particular, we recognize the fundamental role ...
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A perspective on multi target drug discovery and design for complex diseases
... son’s diseases; PDGFR: platelet‑derived growth factor receptor beta; QSAR: quantitative structure–activity relationship; RET: mast/stem cell growth factor receptor kit (SCFR); ROS: reactive oxygen species; SB‑VS: ...
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Sequencing Complex Diseases With HapMap
... Table 1 lists all possible genotypes and diplotypes Suppose there is a random sample of size n drawn at two SNPs genotyped from a sample of size n. Each from a natural human population at Hardy-Weinberg genotype (and ...
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Gene Discovery in Mendelian and Complex Diseases
... In conclusion, we have presented herein the first account of an autosomal recessive EXT2-mediated human disease designated as seizures-scoliosis-macrocephaly (SSM) syndrome. By coupling autozygosity mapping and exome ...
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Association study design of complex diseases: idiopathic scoliosis
... The aim of a genome wide association study (GWAS) is to detect significant associations in a population between common diseases and common genetic variants. In particular, a GWAS is designed to examine millions of ...
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Environment-Sensitive Epigenetics and the Heritability of Complex Diseases
... Diseases and other phenotypes may also exhibit complex inheritance when epigenetic states are environment sensi- tive. In mice, a mother’s grooming and licking of an off- spring can induce epigenetic ...
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Measuring and using admixture to study the genetics of complex diseases
... Many US residents can trace their genetic ancestry to more than one continent. The European colonial period that started in the late 1400s brought together in the New World populations that had been geographically ...
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The synergy factor: a statistic to measure interactions in complex diseases
... Synergy between risk factors Let us take the potential interaction in risk of Alzheimer's disease AD between the ε4 allele of apolipoprotein E APOE4 and the GG genotype of the C/G polymo[r] ...
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Complex genetic diseases: controversy over the Croesus code
... These diseases are common because of highly prevalent non-genetic influences, not because of common disease alleles in the ...of complex diseases by Jonathan Pritchard [12] predicts that neutral ...
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Diabetes and Periodontal Diseases: An Established Two Way Relationship
... periodontal diseases among diabetics, and the death of matrix-pro- ducing cells could limit the possibility of repair in inflamed tissues; it is known that AGEs have harmful effects on extracellular matrix ...
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The Critical Needs and Challenges for Genetic Architecture Studies in Africa
... challenges of studying the genetic architecture of complex traits and diseases in Africa.. For example, with greater genetic diversity comes greater ancestral heterogeneity; this 109[r] ...
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