Cyclophilin A (CypA)
Trim-Cyclophilin A Fusion Proteins Can Restrict Human Immunodeficiency Virus Type 1 Infection at Two Distinct Phases in the Viral Life Cycle
... by cyclophilin A (CypA) following a ...to CypA, suggesting both that the ...HIV-1, CypA was fused to the RBCC of Trim1, Trim18, and Trim19 and tested for ...
7
Fusion of Cyclophilin A to Fv1 Enables Cyclosporine-Sensitive Restriction of Human and Feline Immunodeficiency Viruses
... a cyclophilin A (CypA) pseudogene by ...the CypA domain to the incoming viral ...disrupt CypA binding to its ...fusing CypA to Fv1 generates a restriction factor with the antiviral ...
9
Ochmann, Carmen (2010): CD147 (EMMPRIN) und dessen Ligand Cyclophilin A bestimmen das Ausmaß des myokardialen Schadens nach Ischämie/Reperfusion im Mausmodell. Dissertation, LMU München: Tierärztliche Fakultät
... ist Cyclophilin A an der Pathogenese inflammatorischer Prozesse beteiligt (SATOH K et ...oder CypA zu einer weniger ausgeprägten Inflammation und damit verbunden zu kleineren Infarktarealen nach Ischämie ...
152
Functional analysis of the secondary HIV 1 capsid binding site in the host protein cyclophilin A
... mutant CypA proteins Hela-P4 cells [27] were cultured in Dulbecco’s modifica- tion of Eagle’s medium (DMEM) containing 10% fetal bovine serum and ...encoding cyclophilin A, was disrupted in Hela-P4 cells by ...
13
Original Article Elevated expression of cyclophilin A in human periodontitis
... 2]. CypA is a highly conserved protein that is expressed in a wide range of ...for CypA in rheumatoid arthritis [3, 4], cancer [5], cardiovascular dis- eases [6], sepsis [7], periodontitis [8, 9] and aging ...
7
Evolution of Cyclophilin A and TRIMCyp Retrotransposition in New World Primates
... those, cyclophilin A (CypA) promotes virus infec- tivity by facilitating virus uncoating or capsid unfolding or by preventing retroviral capsid interaction with cellular restriction ...of CypA ...
6
Target Cell Cyclophilin A Modulates Human Immunodeficiency Virus Type 1 Infectivity
... isomerase cyclophilin A (CypA) increases the kinetics by which human immunodefi- ciency virus type 1 (HIV-1) spreads in tissue ...of CypA in HIV-1 replication remains unknown. Though CypA ...
9
Cyclophilin A Interacts with Domain II of Hepatitis C Virus NS5A and Stimulates RNA Binding in an Isomerase-Dependent Manner
... isomerase cyclophilin A (CypA) binds to domain II, catalyzing cis-trans ...isomerization. CypA inhibitors such as cyclosporine (CsA) have been shown to inhibit hepatitis C virus (HCV) ...that ...
5
Decrease in Plasma Cyclophilin A Concentration at 1 Month after Myocardial Infarction Predicts Better Left Ventricular Performance and Synchronicity at 6 Months: A Pilot Study in Patients with ST Elevation Myocardial Infarction
... Background: Cyclophilin A (CyPA) concentration increases in acute coronary ...(LV) CyPA concentration and improved LV ...plasma CyPA con- centrations and LV remodeling in patients with ...
10
Target Cell Type-Dependent Modulation of Human Immunodeficiency Virus Type 1 Capsid Disassembly by Cyclophilin A
... The human immunodeficiency virus type 1 (HIV-1) RNA genome is encapsulated in a conical capsid core, which is delivered into the target cell cytosol as a result of the virus entry process. The HIV-1 capsid is composed of ...
12
trans-Complementation Rescue of Cyclophilin A-Deficient Viruses Reveals that the Requirement for Cyclophilin A in Human Immunodeficiency Virus Type 1 Replication Is Independent of Its Isomerase Activity
... mutant CypA lacking these four residues to Vpr and tested the resulting chimera for its ability to rescue HIV-1 replication in the pres- ence of ...of CypA or residues distinct from the four residues ...
8
Expression and prognostic relevance of Cyclophilin A and matrix metalloproteinase 9 in esophageal squamous cell carcinoma
... Tissue specimens were fixed in neutral buffered formalin (10% v/v formalin in water; pH 7.4) and embedded in paraffin wax. Serial sections of 4-μm thickness were cut and mounted on charged glass slides. The mono- clonal ...
6
Cyclophilin A promotes HIV 1 reverse transcription but its effect on transduction correlates best with its effect on nuclear entry of viral cDNA
... HeLa clone 3D bearing hT5Cyp-H436Q was chal- lenged with envelope-minus HIV-1 pseudotyped with VSV G, bearing either WT or A92E CA, in the presence of CsA or DMSO as solvent control. 16 hrs post- transduction, cells were ...
15
Cells with High Cyclophilin A Content Support Replication of Human Immunodeficiency Virus Type 1 Gag Mutants with Decreased Ability To Incorporate Cyclophilin A
... that CyPA-containing vesicles were not produced under these conditions (4, ...of CyPA similar to those in wild-type virions (15), were analyzed as an additional control ...
6
Induction of G2 Arrest and Binding to Cyclophilin A Are Independent Phenotypes of Human Immunodeficiency Virus Type 1 Vpr
... of CypA ⫹ and CypA ⫺/⫺ cells at a multiplicity of infection (MOI) of ...of CypA ⫺/⫺ cells were routinely low (between ...for CypA in target cells during the uncoat- ing step (9, 18, ...of ...
7
Trojans in Wireless Sensor Networks
... (113). CypA performs an essential function during the maturation of the HIV-1 virus, catalyzing cis-trans isomerization of a -Gly-Pro- motif on an exposed loop of the HIV-1 capsid monomer in order to facilitate ...
162
CYPA promotes the progression and metastasis of serous ovarian cancer (SOC) in vitro and in vivo
... patients. Cyclophilin A (CYPA) is a member of Cyclophilin family and thought to participates in multiple cellular processes such as cell transduction and immune ...that CYPA has critical ...
9
The hydrophobic pocket of cyclophilin is the binding site for the human immunodeficiency virus type 1 Gag polyprotein.
... isomerase cyclophilin A (CyPA) by the Gag polypro- ...of CyPA would be aided by a detailed analysis of the genetic requirements for the formation of the Gag-CyPA complex; previous experiments ...
7
Original Article Changes of serum CypA and CNP levels in type 2 diabetes mellitus patients with vascular lesions and its clinical prognostic significance
... serum cyclophilin A (CypA) and C-type natriuretic peptide (CNP) levels in patients with type 2 diabetes mellitus (T2DM) with vascular lesions and evaluate their clinical prognostic ...Serum CypA, ...
6
Role of Human Immunodeficiency Virus Type 1 Integrase in Uncoating of the Viral Core
... of cyclophilin A (CypA), a cellular peptidyl-prolyl isomer- ase that binds specifically to CA, was decreased in the IN ...of CypA had an unstable-core phenotype, confirming a role of CypA in ...
10