Desorption electrospray ionization
Development and Application of Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Imaging for Drug Distribution Studies.
... Ambient ionization techniques such as desorption electrospray ionization (DESI) [10], liquid extraction surface analysis (LESA) [11], and matrix-assisted laser desorption ...
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Advancements in Infrared Matrix Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Instrumentation and Methodology.
... 49 methods, which typically require several minutes of analysis time per sample. 5 In addition, most MS-based methodologies are susceptible to the presence of nonvolatile compounds such as salts, buffers, and detergents ...
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Development and Characterization of an Atmospheric Pressure Ionization Source Matrix-Assisted Laser Desorption Electrospray Ionization Coupled to Fourier Transform Ion Cyclotron Resonance Mass Spectrometry for Analysis of Biological Macromolecules
... maximum ionization time was set to 1 second and resolving power set to 100,000 at 400 ...m/z. Electrospray ionization was generated by infusing the ESI solution (50 % acetonitrile in water) through a ...
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Native Desorption Electrospray Ionization Liberates Soluble and Membrane Protein Complexes from Surfaces
... require electrospray (ES) ioniza- tion and have not been achieved via direct desorption from ...surfaces. Desorption ES ionization (DESI) MS has however transformed the study of tissue ...
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Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI): Development and Applications in Metabolomics, Mass Spectrometry Imaging, and Direct Analysis.
... the electrospray to stabilize before sampling the subsequent ...each ionization mode, could be performed, and the amount of time, in milliseconds, required to analyze the tissue sections in both modes can ...
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Matrix-Assisted Laser Desorption Electrospray Ionization: Fundamental Principles and Applications Toward Direct Analysis and Molecular Imaging.
... Woburn, MA, USA). High voltage, applied to a stainless steel union (MU1XCS6, VICI Valco, Houston, TX, USA) just prior to the emitter tip, was varied between 2.0 and 3.5 kV such that the electrospray was stabilized ...
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Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry Imaging (IR-MALDESI MSI): Fundamentals, Source Design and Data Analysis.
... , electrospray ionization has rapidly become a method of choice to transfer large biomolecules to the gas phase to be analyzed using mass ...of electrospray and attempt to characterize the ESI modes, ...
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The Development of Desorption Electrospray Ionization and Nano Flow Liquid Chromatography Mass Spectrometric Methods for Glycan Analysis: Applications for Biomarker Discovery in Epiethelial Ovarian Cancer
... this group of ambient methods. In DESI, charged solvent droplets are accelerated by high pressure nitrogen gas toward an analyte bearing surface. These droplets impact the surface and analyte containing secondary ...
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Imaging mass spectrometry approaches for the detection and localisation of drug compounds and small molecules in tissue
... "Comparison of drug distribution images from whole-body thin tissue sections obtained using desorption electrospray ionization tandem mass spectrometry and autoradiography." Analytical C[r] ...
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Ambient DESI and LESA MS analysis of proteins adsorbed to a biomaterial surface using in situ surface tryptic digestion
... of desorption electrospray ionization (DESI) and liquid extraction surface analysis (LESA) mass spectrometry (MS) coupled with in-situ surface tryptic digestion to identify protein species from a ...
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A Mass Spectrometric Study of Kratom Compounds by Direct Infusion Electrospray Ionization Triple Quadrupole Mass Spectrometry
... Mitragynine (MG) and its major metabolites 7-hydroxymitragynine (7-OH-MG) are two of the ma- jor components of the plant extract Kratom, which is a tree planted in Southeast Asia. Kratom has long been used by ...
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Molecular Probes in Tandem Electrospray Ionization Mass Spectrometry: Application to Tracing Chemical Changes of Specific Phospholipid Molecular Species
... New ionization and detection techniques in mass spectrometry have been successfully applied for efficient analyses of complex biological ...tandem electrospray ionization mass spectrometry has been ...
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Characterisation of pharmaceutical and polymer formulations by novel mass spectrometry approaches
... of electrospray had been commenced in the mid 18 th century, when scientists such as Nollet observed the physical properties of liquids in glass capillaries to which an electrical potential had been applied ...
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Expression, Characterization and Metallation Studies of Human Metallothionein Isoform 2a Using Electrospray Ionization Mass Spectrometry
... electrospray carrier solvent in the positive ion mode. The mass spectrometer was calibrated using sodium iodide (NaI). Settings: scan = 500-4000 m/z; rolling average = 2; nebulizer = 2 bar; dry gas = 180°C @ 6.0 ...
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A Hyphenation of Stripping Voltammetry with Electrospray Ionization Mass Spectrometry; an Effect of Sodium Perchlorate on Ferrocene Oxidation
... In order to gain complementary insight into the nature of the complexes formed, electrospray ionization mass spectrometry (ESI-MS) has been used to assess the types of metal complexes [17-22]. In many ...
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Prediction of the Fragmentation Pathway of Atorvastatin De Protonated Ion
... spray negative ionization mode with flow injection analysis; using liquid chromatography systems coupled with tandem mass spectrometers (Q-trap and Q-ToF). Results: The fragmentation pathway was established using ...
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Rapid determination of aminoglycosides in pharmaceutical preparations by electrospray ionization mass spectrometry
... Aminoglycosides are broad-spectrum antibiotics often employed to combat Gram-negative bacterial infections. A technique based on electrospray-ionization mass spectrometry (ESI-MS) was developed for rapid ...
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Molecular Dynamics Simulations of Charged Nanodroplets
... an electrospray ionization (ESI) perspective [2-15], although charged droplets also play an important role in atmospheric ...used ionization methods for mass spectrometry (MS) [16], and it allows the ...
217
Ranitidine hydrochloride: An update on analytical, clinical and pharmacological aspects
... Pratiwi D et al performed quantitative analysis of polymorphic mixture of ranitidine hydrochloride by Raman spectroscopy and principal component analysis (PCA). Study demonstrated that PCA of Raman spectroscopic data ...
9
Aqueous extract of <em>Rabdosia rubescens</em> leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis
... detector/(-)electrospray ionization-tandem mass spectrometry analysis into the active site of P-selectin, rosmarinic acid was predicted to be the antithrombotic ingredient of ...
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