Discovery and Optimization
Thermodynamics guided lead discovery and optimization
... drug discovery still tends to generate complex and apolar struc- tures that are not ideally suited for clinical ...lead discovery (i.e. hit-to-lead optimization is responsible for an unfa- vorable ...
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Probabilistic latent variable models for knowledge discovery and optimization
... In this thesis, I describe a range of applications where latent variables can be leveraged for knowledge discovery and efficient optimization. Works in this thesis demonstrate that PLVMs are a powerful tool ...
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Genetically Optimized Multiple ANFIS Based Discovery and Optimization of Catalytic Materials
... new optimization architecture for the intelligent discovery of new catalytic materials integrates an M-ANFIS and a genetic algorithm, being the integration/interaction between both very ...dimensional ...
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Promoting content discovery of open repositories : reviewing the impact of optimization techniques (2016-2019)
... the discovery needs of both human and machine users is of grow- ing importance and essential to validate the continued relevance of open repositories to users, and as nodes within open scholarly communication ...
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Research Article Optimization Framework and Parameter Determination for Proximity-Based Device Discovery in D2D Communication Systems
... of discovery, which determines the proximity of devices. When a discovery process is performed, there are several parameters to determine, including the discovery range, the discovery period, ...
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A VOYAGE OF DISCOVERY Data Center Optimization Requires Comprehensive Knowledge of All Data Center Assets and Relationships
... a discovery phase is a necessary first phase of a data center optimization ...the discovery phase is ongoing, new equipment may be added and applications may ...the discovery phase deliverable ...
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Discovery and optimization of inhibitors of the Parkinson s disease associated protein DJ-1
... 65. Kobe, A., Caaveiro, J. M. M., Tashiro, S., Kajihara, D., Kikkawa, M., Mitani, T., and Tsumoto, K. (2013) Incorporation of rapid thermodynamic data in fragment-based drug discovery, J. Med. Chem. 56, 2155-2159. ...
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Discovery of Complex Behaviors through Contact-Invariant Optimization
... The most progress towards this ambitious agenda has been made in the domain of walking. After three decades of intensive research, we now have algorithms that can make simulated humanoids walk robustly and realistically ...
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A Latent Trust Discovery Algorithm Based on Optimization of Trust Network
... the discovery algorithm to find the latent trust and compute the trust value of user-to-commodity trust which can help customers to directly make the final purchase ...
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An Optimization Algorithm of Network Topology Discovery Based on SNMP Protocol
... topology discovery, in order to avoid be- cause of the next-hop router with the tube field equipment passwords in the same communication program to expand on the network; CommunitySnmp ReadLiSt said read password ...
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A constraint optimization framework for discovery of cellular signaling and regulatory networks
... 2 Integrating proteomic, transcriptional, and interactome data reveals hidden components of signaling and regulatory networks: case study of the yeast pheromone response netwo[r] ...
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Toward the optimization resource discovery service in grid systems: a survey
... decentralized discovery method in grid environments has proposed by ...resource discovery solution consists of four components: membership protocol, overlay construction, preprocessing, and request ...
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The challenge of selecting protein kinase assays for lead discovery optimization
... drug discovery process, present the advantages and disadvantages of each of these methods, and discuss the challenges of discovering kinase inhibitors by using these ...
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Comparing Apples and Bananas? A/B Testing for Discovery System Optimization
... a discovery system with a traditional database, our previous research included two configurations of Summon: a default version that was inclusive of formats and subjects and a pre-scoped version that was limited ...
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A Comparative Study of Classification Rule Discovery with Ant Colony Optimization: AntMiner
... 5. Conclusion and Future work We discussed discovery of classification rules by using AntMiner and its variations. The outcome of a discovered rule is affected by previously discovered rules depends on the ...
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Machine learning workflow optimization via automatic discovery of resource reuse opportunities
... compiler optimization technique known as common subexpression elimination (CSE) tries to replace the frequently- occurring expressions in code with a temporary ...
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Promoting content discovery of open repositories : reviewing the impact of optimization techniques (2016-2019)
... https://doi.org/10.1177/0266666912466754. 3. Tonkin, Emma L., Stephanie Taylor, and Gregory J. L. Tourte. “Cover Sheets Considered Harmful.” Information Services & Use 33, no. 2 (January 2013): 129–137. ...
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Comparison of Community Structure Partition Optimization of Complex Networks by Different Community Discovery Algorithms
... This paper briefly introduces three algorithms for community structure partition of complex networks, which were based on the similarity of common neighbor nodes, ant colony algorith[r] ...
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Low SAR Path Discovery by Particle Swarm Optimization Algorithm in Wireless Body Area Networks
... Fig.2. Packet success rate. In the following, this paper aims at discovering the best position of the relay node. For problem solving, Genetic Algorithms (GA) is one of the algorithms often used to solve ...
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Particle swarm optimization for time series motif discovery
... multimodal optimization, time series streams, motifs, ...motif discovery is fundamental for understanding, characterizing, modeling, and predicting the system behind the time series ...motif ...
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