DNA binding
Prediction of DNA-Binding Proteins and their Binding Sites
... predicting DNA-binding proteins using machine learning, involves two important steps: i) extraction of relevant features; and ii) selection of an appropriate classification ...for DNA-binding ...
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SUMO 1 possesses DNA binding activity
... with DNA exhibiting different dissocia- tion constants related to various sites of the TDG-N pro- tein ...DNA binding. Based on the ability of SUMO-1 to compete with TDG-N to bind DNA, as ...
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MMPP Attenuates Non-Small Cell Lung Cancer Growth by Inhibiting the STAT3 DNA-Binding Activity via Direct Binding to the STAT3 DNA-Binding Domain
... Figure 3. MMPP inhibits STAT3 DNA-binding activity in NCI-H460 cells. (a-b) NCI-H460 NSCLC cells were treated with MMPP (0-15 μg/mL) for 6 h and then lysed with buffers A and C. Nuclear extracts were ...
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The Genetics of Transcription Factor DNA Binding Variation
... or binding quantitative trait loci (tfQTLs or bQTLs), as their detection suggests that a polymorphism within this locus causally affects the ability of a TF to bind to ...affect DNA binding of the ...
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Adenovirus-specific DNA-binding protein inhibits the hydrolysis of DNA by DNase in vitro.
... Adenovirus H5 wild type or ts125 2 was Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The adenovirus-specific DNA-binding protein was isolated from adenovirus type 5-i[r] ...
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Localization of DNA binding polyamides in living cells
... of DNA-binding proteins rely on major groove contacts to provide sequence specificity, though a few, such as TATA-binding protein, utilize minor groove ...novel DNA-binding properties ...
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Drosophila DNA-Binding Proteins in Polycomb Repression
... PRE-associated DNA-binding proteins are likely to be discovered in the nearest ...specifically binding to various DNA ...between DNA-binding proteins and PcG complexes, as well ...
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GENERAL SELECTION FOR SPECIFIC DNA-BINDING ACTIVITIES
... Challenge phages with other operators: T o test whether the challenge phage selection could be applied in a general way to DNA-binding protein/ site interactions, [r] ...
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Roles of gastric GATA DNA binding proteins
... the DNA-binding site of the GATA-binding protein (Yang and Evance, 1992), phosphorylation and dephosphorylation near the second finger of GATA-GT1 and GATA-GT2 may affect their DNA ...
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Drug DNA Interaction: A Theoretical Study of the Stability of CP DNA Binding with Thionine
... on binding of small molecules to double stranded DNA suggested that the intercalation of a tricyclic heteroaromatic molecule, thionine, with natural DNA provided thermal stabilization to the ...
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Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage
... UV-damaged DNA, cisplatin-modified DNA, as well as single-stranded DNA with high affinities ...damaged-DNA binding activity of DDB2 has been implicated in its nucleotide excision repair ...
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Studies of the Silencing of Baculovirus DNA Binding Protein
... LEF-3, like DBP, is a single-stranded DNA binding protein (3, 7, 14, 17). In vitro assays revealed multiple functions of LEF-3, suggesting a role in viral replication, repair, and re- combination of the ...
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Evidence for glycosylation on a DNA-binding protein of Salmonella enterica
... Several works have demonstrated that the bacterial cell accumulates large amounts of Dps during the stationary growth phase [1,3,5,27,28,40]. Thus, when the bacterial cell faces nutritional depletion during the ...
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Regulation of Sp2 DNA-Binding Activity and trans-Activation
... bind DNA, COS-1 cells were transiently transfected with an EYFP-Sp2 expression vector, non-denatured nuclear extracts were prepared, and these and control extracts were subsequently incubated with a radiolabeled ...
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“Calling Cards” for DNA-Binding Proteins in Mammalian Cells
... transcription-factor binding at the moment the protein is cross-linked to ...factor binding events to subse- quent fates of the ...TF– DNA interactions that occurred at the time in the culture’s (or ...
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A Biophysical Approach to Predicting Protein–DNA Binding Energetics
... and DNA play a central role in DNA replication, repair, recombination, and control of gene ...protein–DNA binding specificities from high-through- put in vitro ...alternative ...
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Identification of the DNA binding element of the human ZNF300 protein
... its DNA binding sequence in ...consensus DNA sequence recognized by ...selected DNA consensus for ZNF300. Furthermore, we investigated the DNA-binding property and ...
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Inhibitor of DNA binding in heart development and cardiovascular diseases
... by binding to the target gene at a specific recognition motif in the pro- moter region, named E-box (CANNTG) or N-box (CACNAG) ...of DNA binding (Id) proteins belong to the HLH family of ...
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DNA Binding Activity of the Herpes Simplex Virus Type 1 Origin Binding Protein, UL9, Can Be Modulated by Sequences in the N Terminus: Correlation between Transdominance and DNA Binding
... origin binding protein of herpes simplex virus type 1, is a member of the SF2 family of ...viral DNA and plasmids expressing either full-length UL9 or the C-terminal DNA binding domain alone ...
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Mutations in the DNA-binding and dimerization domains of v-Rel are responsible for altered kappa B DNA-binding complexes in transformed cells.
... different DNA-binding specificities of NF- k B1/p50 and ...the DNA-binding specificity of ...different DNA-binding specificities ...the DNA-binding specificity of ...
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