DNA structures
Molecular topography of the MED12-deleted region in smooth muscle tumors: a possible link between non-B DNA structures and hypermutability
... folded DNA to its specific functions and behaviour as ...folded DNA in a number of processes is well documented (for review see [21]) and in eukaryotes as well, non-B DNA structures seem to ...
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Determinants of genome editing outcomes: the impact of target and donor DNA structures
... however, Yoshioka et al. showed that ribozyme-flanked sgRNAs expressed from the RNA Pol II CAG promoter (CAG-HH-gRNA-HDV) induced less genome editing events than those from the commonly used U6-driven sgRNA [68]. ...
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In Silico Sequence Optimization for the Reproducible Generation of DNA Structures
... non-target structures, 36 thermodynamically unfavorable non-target structures, 37 and structure ...B- DNA duplex, this system begins with a high degree of bad structural behavior and makes a ...
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Unusual DNA Structures Associated With Germline Genetic Activity in Caenorhabditis elegans
... D NA carries biological information on a variety of levels. Some of the information is evident from well-defined sequence features such as the genetic code and certain reproducible transcription factor binding sites. ...
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The roles of adenoviral vectors and donor DNA structures on genome editing
... chromosomal DNA integration pattern of these oncoretroviral vectors is biased towards transcription start sites and CpG islands [72], increasing the risk of insertional mutagenesis by “landing” in or near a ...
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The Acceleration of DNA may Generate cancer
... of DNA is ...in DNA structures and cause to cancer or DNA destroy ...of DNA to ...in DNA is ...the DNA hole and information is ...
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Need telomere maintenance? Call 911
... on DNA can cause DNA replication fork stalling and such an event in checkpoint-deficient cells has been shown to lead to fork reversal and hyper-recombination ...of DNA polymerase show chromosomal ...
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Function of gene 49 of bacteriophage T4. II. Analysis of intracellular development and the structure of very fast-sedimenting DNA.
... The demonstration by the electron microscope of branched DNA structures sometimes closely related to partially filled heads is taken in support of the idea that the process of head filli[r] ...
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A sandwich-type DNA electrochemical biosensor for hairpin-stem-loop structure based on multistep temperature-controlling method
... for DNA recognition of hairpin secondary ...special DNA structures, such as those that possess an internal double-helical state, the hybridization efficiency was directly reduced and the ...
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PubMedCentral-PMC4857006.pdf
... damaged DNA triggers of Top2-DNA protein crosslink formation are unavoidable ...complex DNA breaks bearing topoisomerase–DNA protein crosslinks is key to deciphering individual responses to ...
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A DFT study of 2 aminopurine containing dinucleotides: prediction of stacked conformations with B DNA structure
... optimised structures of three guanine (G) dinucleotides, 5'- d(GpX)-3', where X was thymine, uracil or 5-bromouracil, were compared with typical B-DNA ...The structures were further scrutinised by ...
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Branched structures in the intracellular DNA of herpes simplex virus type 1.
... direct a sequences would produce larger circular concatemers. Figure 5C illustrates the effects of recombination between a newly replicated a sequence and a still unreplicated a sequence within the same circular genome. ...
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Human RECQ1 helicase-driven DNA unwinding, annealing, and branch migration: insights from DNA complex structures
... crystal structures, to our knowledge, of human RECQ1 in complex with ...helicase structures, provide detailed insights on the RecQ helicase mechanisms of DNA tracking, strand separation, and strand ...
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Integrated structures of duck hepatitis B virus DNA in hepatocellular carcinoma.
... Among four hepadnaviruses, various structures of integrated viral DNA in hepatocellular carcinoma have been reported for human hepatitis B 3, 4, 6, 10, 17, 22, 24, 29, 31 and woodchuck h[r] ...
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Secondary structures in polyoma DNA.
... Several lines of evidence indicate that the inverted repeat stems of the two secondary-structure loops lie in the regions of polyoma virus DNA flanking and probably very close to the seq[r] ...
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A P-Element Insertion Screen Identified Mutations in 455 Novel Essential Genes in Drosophila
... genomic DNA sequence flanking the in- ligation mixture was incubated overnight at ...genomic DNA adjacent to the 5⬘, 3⬘, or both sides of and 9700 using the following parameters: 1 time at 95⬚/5 ...
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p53 and RPA Are Sequestered in Viral Replication Centers in the Nuclei of Cells Infected with Human Cytomegalovirus
... of DNA replication by dem- onstrating both incorporation of bromodeoxyuridine and localization of UL44 (the viral polymerase proces- sivity factor) into these ...single-stranded DNA binding protein RPA was ...
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Structural Basis of Bloom Syndrome (BS) Causing Mutations in the BLM Helicase Domain
... subfamily DNA heli- cases WRN (SWISS_PROT: Q14191), BLM (P54132), RECQL (P46063), SGS1 (P35187), RecQ (P15043) and Rqh1(Q09811) were re- trieved from sequence ...PcrA DNA helicases. The crystal ...
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Identification of two nuclear subclasses of the adenovirus type 5-encoded DNA-binding protein.
... To determine whether the DBP globular structures colocalized with viral DNA centers, the same infected cells were subjected to both in situ hybridization with the biotinylated adenovirus[r] ...
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Mechanism of Antiviral Action of Acetone on Rabbitpox Virus Replication
... DISCUSSION The main experimental finding of these studies is that in rabbitpox virus-infected L cells there occurs, in the presence of acetone, the formation of DNA-containing structures[r] ...
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