Dual specificity
RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.
... RET dual-specificity kinase activity and show that an equivalent serine is required for RET signaling in Drosophila ...reveal dual-specificity and allosteric components for the mechanism of ...
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Characterization of the catalytic properties of dual specificity protein tyrosine phosphatase hYVH1.
... termed Dual Specificity Protein Tyrosine Phosphatase, ...the dual specificity PTPs family is increasingly growing involving a wide range o f enzymes such as VH1- like DUS PTP, phosphatase of ...
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Human Dual Specificity Phosphatase hYVH1: Structural Insights and Functions in Stress Granule Dynamics
... the dual specificity phosphatase (DUSP) sub-families ...the specificity and reaction rate of labeling reagents used for modification, enrichment and ...
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The dual-specificity phosphatase encoded by vaccinia virus, VH1, is essential for viral transcription in vivo and in vitro.
... Vaccinia virus encodes two serine/threonine kinases (B1 and F10) (2, 27, 28, 36, 54, 55) as well as the dual-specificity H1 phosphatase. Both the F10 kinase and the H1 phosphatase are present in ...
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Suppression of dual specificity phosphatase–2 by hypoxia increases chemoresistance and malignancy in human cancer cells
... phosphatase dual-specificity phosphatase–2 (DUSP2) is markedly reduced or com- pletely absent in many human cancers and that its level of expression inversely correlates with that of HIF-1α and with cancer ...
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Functional cdc25C dual-specificity phosphatase is required for S-phase entry in human cells
... Although the described cdc25C-depletion experiment seemed to specifically target cdc25C with respect to the other cdc25 isoforms, there remained the possibility that they interfered with another as yet unidentified ...
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Functional Regulation of Dual Specificity Phosphatases: Modifications, Methods for Analysis, and Mass Spectrometry
... substrate specificity, but through large differences among three-dimensional structure, association with protein effectors, regulatory domains and catalytic mechanism ...(VH1)-like dual-specificity ...
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Designing fluorescent peptide sensors with dual specificity for the detection of HIV‑1 protease
... The experimentally observed inhibitory action of both peptides may be due to interference with the opening of the flaps rather than occupation of the active site as seen with other inhibi[r] ...
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Structure-Function Characterization of the Human Dual Specificity Phosphatase hYVH1
... However, mutants comprised of the catalytic domain and fragments of the zinc-binding domain (CT2, CT3) are able to surpass polyploid cell numbers seen with overexpress[r] ...
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Emerging Regulatory Roles of Dual-Specificity Phosphatases in Inflammatory Airway Disease.
... Much of the literature regarding DUSPs in innate immunity have focused on bacterial infection, and few studies have examined their roles in viral infection. DUSP1 (MKP1) is the archetype of the family and the most well ...
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Merkel cell polyomavirus and Langerhans cell neoplasm
... DC: Dendritic cell; DUSP6: Dual specificity phosphatase 6; ELISA: Enzyme- linked immunosorbent assay; ERK: Extracellular signal-regulated kinase; ITIH4: Interalpha-trypsin inhibitor heav[r] ...
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Tyrosine Phosphorylation of A17 during Vaccinia Virus Infection: Involvement of the H1 Phosphatase and the F10 Kinase
... the Thr and Tyr residues within the TXY motif of their sub- strates (8, 16) are among the best-studied examples of such enzymes. Dual-specificity kinases resemble Ser/Thr kinases in their primary sequences ...
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Mitogen activated protein kinase phosphatase 1 in rat arterial smooth muscle cell proliferation
... Smooth muscle cell proliferation and migration is impor- tant in arteriosclerosis. In this process, cytokines and growth factors are upregulated and bind to their respective receptors, which in turn stimulate ...
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MAP kinase phosphatases
... 16 dual specificity and low- molecular-weight phosphatases and five phosphatase-like STYX ...yeast dual specificity phosphatase gene MSG5 in the regulation of the MAP kinase Fus3 ...
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<em>DUSP4</em>/MKP2 overexpression is associated with BRAF<sup>V600E</sup> mutation and aggressive behavior of papillary thyroid cancer
... Abstract: The study was performed to retrospectively analyze the correlation of dual specificity phosphatase 4 (DUSP4) expression with clinicopathological variables and BRAF V600E mut[r] ...
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Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells
... DUSP: Dual-specificity phosphatase; EBs: Embryoid bodies; EpiSCs: Post-implantation epiblast- derived stem cells; FGF2: Fibroblast growth factor 2; FGFR: Fibroblast growth factor receptor; FPKM: Fragments ...
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Role and regulation of MKP-1 in airway inflammation
... MKP-1 can be predicted by homology modeling [32]. As shown schematically in Fig. 1, MKP-1 has two cdc-25 homology domains A (CH2A) and B (CH2B) and a con- served protein tyrosine phosphatase (PTP) catalytic site [34, 35, ...
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Lipid raft/caveolae signaling is required for Cryptococcus neoformans invasion into human brain microvascular endothelial cells
... Jong A: Invasion of Cryptococcus neoformans into Human Brain Microvascular Endothelial Cells Is Mediated through the Lipid Rafts- Endocytic Pathway via the Dual Specificity Tyrosine Phos[r] ...
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Malaria protein kinase CK2 (PfCK2) shows novel mechanisms of regulation
... Casein kinase 2 (protein kinase CK2) is a conserved eukaryotic serine/theronine kinase with multiple substrates and roles in the regulation of cellular processes such as cellular stress, cell proliferation and apoptosis. ...
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Evaluation of Gamma Interferon and Antibody Tuberculosis Tests in Alpacas
... DPP rapid antibody test. The Dual Path Platform (DPP) test (Chem- bio Diagnostic Systems, Inc.) consists of two nitrocellulose strips inside a cassette that allows independent delivery of the test sample and ...
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